SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | REGULATION OF ION CHANNELS |
| Discussion Leader: Joseph Mindell (NIH/NINDS) |
7:40 pm - 8:05 pm | David Yue (Johns Hopkins University)
"Competition at its finest - novel connectivity between the two signaling uber hubs of Ca2+ channels and calmodulin" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Rachelle Gaudet (Harvard University)
"Structural Insights into the Function of TRPV Channels" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | William Zagotta (University of Washington)
"Molecular mechanisms for regulation of ion channels by cyclic nucleotide" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEUROTRANSMITTER TRANSPORTERS |
| Discussion Leader: Nancy Carrasco (Albert Einstein College of Medicine) |
9:00 am - 9:35 am | Gary Rudnick (Yale University)
"Conformational change we can believe in: Opening the cytoplasmic permeation pathway of neurotransmitter transporters" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Baruch Kanner (Hebrew University)
"What is chloride doing to sodium-coupled neurotransmitter transporters?" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:25 am | Joseph Mindell (NIH/NINDS)
"Transporter dynamics in a bacterial 'glutamate' transporter" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:10 pm | Olga Boudker (Cornell University Medical School)
"Alternating access mechanism of glutamate transporters" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SELECTED POSTER TALKS: SESSION A |
| Discussion Leader: Chris Miller (Brandeis University) |
| (short talks selected from posters) |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MEMBRANE PROTEIN TRANSPORT AND ASSEMBLY |
| Discussion Leader: Stephen White (University of California, Irvine) |
9:00 am - 9:35 am | William Skach (Oregon Health Sciences University)
"Transport/assembly of aquaporin" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Arnold Driessen (University of Groningen)
"Mechanism of lateral pore opening of the preprotein translocase" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:25 am | Nils Wiedemann (Universitat Freiburg)
"Biogenesis of Mitochondrial Membrane Proteins" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:10 pm | Jochen Zimmer (Harvard University)
"Structural Basis for SecA mediated protein translocation" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LIPID PROTEIN INTERACTIONS |
| Discussion Leader: William Skach (Oregon Health Sciences University) |
7:30 pm - 8:00 pm | Stephen White (University of California, Irvine)
"Lipid interactions of Kv Channels and Voltage-Sensor Domains" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Alexey Ladokhin (University of Kansas)
"Thermodynamic and kinetic characterization of pH-triggered membrane protein insertion" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Zhe Lu (University of Pennsylvania)
"Clues to the pathogenesis of cystic fibrosis" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PUMPING ION: P-TYPE ATPASES |
| Discussion Leader: Amy Davidson (Purdue University) |
9:00 am - 9:35 am | Svetlana Lutsenko (Oregon Health Sciences University)
"Regulation of copper transport at the molecular and cellular level" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Miguel Holmgren (NIH/NINDS)
"Na+ access kinetics to the Na/K ATPase" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:25 am | David Gadsby (Rockefeller University)
"Ion pathway through the Na,K-ATPase pump" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:10 pm | Jesper Vuust Møller (University of Aarhus)
"How SERCA pumps Ca2+ and can be targeted by thapsigargin" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | ION CHANNELS / SELECTED POSTER TALKS: SESSION B |
| Discussion Leader: William Zagotta (University of Washington) |
7:30 pm - 8:00 pm | (short talks selected from posters) |
8:00 pm - 8:35 pm | Ricarda Hilf (University of Zurich)
"Ion permeation and gating in prokaryotic pentameric ligand-gated ion channels" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | Rod Mackinnon (Rockefeller University)
"K+ channel structure and mechanism" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ION MOTIVE FORCE-DEPENDENT TRANSPORTERS |
| Discussion Leader: Joseph Mindell (NIH/NINDS) |
9:00 am - 9:35 am | Nancy Carrasco (Albert Einstein College of Medicine)
"The sodium/iodide symporter (NIS): an unending source of surprises" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Salem Faham (David Geffen School of Medicine, UCLA)
"Crystal structure of SGLT reveals mechanism of Na+/Sugar cotransport" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:25 am | Chris Miller (Brandeis University)
"A virtual proton pump driven by arginine decarboxylation" |
11:20 am - 11:35 am | Discussion |
11:35 am - 12:10 pm | Ron Kaback (UCLA)
"The old man and the transporter" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ABC TRANSPORT |
| Discussion Leader: Robert Tampé (Johann Wolfgang Goethe-Universität) |
7:30 pm - 8:00 pm | Joseph Bryan (Pacific NW Diabetes Research Inst.)
"Regulation of an ion channel: another role for a transporter" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | David Clarke (University of Toronto)
"Repair of folding defects in CFTR using pharmacological chaperones" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jue Chen (Purdue University)
"Alternating access in the maltose transporter" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |