SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:40 pm | Lipids, Proteins, and their Interactions |
| Discussion Leader: Steve White (UC Irvine) |
7:40 pm - 8:05 pm | Olaf Anderson (Weill Cornell Medical School) "Lipid bilayer perturbation by small molecules: Implications for membrane protein function" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Paula Booth (University of Bristol) "Folding membrane transporters; insights into transition states and lipid control mechansims" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:30 pm | Data Blitz |
| 8 posters from students and postdocs will be chosen for 2-slide, 5-minute presentations with a single question each. |
|
- Emma Compton (University of Dundee)
"Low resolution structure of a dimeric SLC26 transporter suggests a dynamic multidomain organisation"
- Osi Iyalomhe (Johns Hopkins Medical School)
"Interaction between TM5 and TM11 in a Major Facilitator Superfamily transporter"
- Avner Schlessinger (UCSF)
"Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET"
- Eric Geertsma (University of Zurich)
"A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology"
- Vicki Kaiser Jensen (Nordic Bioscience)
"Oligomerization of the osteoclastic chloride transporter ClC-7 demonstrated by Bioluminescence Resonance Energy Transfer (BRET)"
- David Shaya (UCSF)
"Voltage-gated sodium channel (NaV) protein dissection creates a set of functional 'pore-only' proteins"
- Giray Enkavi (University of Illinois at Urbana Champaign)
"Permeation and Selectivity of Urea Transporters"
- Niels Quashie (University pf Ghana Medical School)
"Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mediated by human transporters rather than the parasite-induced New Permeation Pathways"
|
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:10 am | Na+-coupled Transporters |
| Discussion Leader: Christine Zeigler (Max Planck, Frankfurt) |
9:00 am - 9:25 am | Jeff Abramson (UCLA) "The mechanism of sodium and substrate release from the binding pocket of vSGLT" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Lucy Forrest (Max Planck, Frankfurt) "Evolution and functional roles of inverted-topology repeats in secondary transporters" |
10:00 am -10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:45 am | Camillo Perez (Max Planck, Frankfurt)
"Structural basis for activity regulation in the Na+/Betaine symporter BetP" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Carla Portulano (Albert Einstein College of Medicine)
"When architecture matters: a polarized transepithelial I- transport model provides insights into the cell biology, physiology and transport mechanism of the Na+/I- symporter (NIS)" |
11:05 am - 11:10 am | Discussion |
11:10 am - 12:30 pm | A Debate on Transporter Stoichiometry |
| Mediated by Chris Miller (Brandeis University) |
11:10 am - 11:30 am | Eric Gouaux (Vollum Institute) "Substrate stoichiometry of LeuT" |
11:30 am - 11:35 am | Brief Discussion |
11:35 am - 11:55 am | Jonathan Javitch (Columbia University) "The LeuT transport mechanism: experimental conditions can obscure a second substrate binding site required for Na+-coupled transport" |
11:55 am - 12:00 pm | Brief Discussion |
12:00 pm - 12:10 pm | Rebuttal by Eric Gouaux |
12:10 pm - 12:20 pm | Rebuttal by Jonathan Javitch |
12:20 pm -12:30 pm | Open Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Small Solute Channels |
| Discussion Leader: Bob Stroud (UCSF) |
7:30 pm - 7:55 pm | Da Neng Wang (NYU) "Ion selectivity of FNT channels" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Ming Zhou (Columbia University) "Structure and mechanism of a mammalian urea transporter" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Tamir Gonen (University of Washington) "The dynamic regulation of aquaporin-0" |
9:10 pm - 9:20 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CLC channels and Transporters |
| Discussion Leader: Joe Mindell (NIH/NINDS) |
9:00 am - 9:25 am | Michael Pusch (CNR, Genoa)
"A beta subunit associated with ClC-2 Chloride channels" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Merritt Maduke (Stanford University)
"Inhibiting CLC transporters" |
9:45 am - 9:55 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Alessio Accardi (Weill Cornell Medical School)
"Molecular bases of substrate coupling in a CLC exchanger" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:35 am | Rod Mackinnon (Rockefeller University)
"Structure and Function Studies of a Eukaryotic CLC" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Chris Miller (Brandeis University)
"Intractable conundrums in CLC antiporter mechanisms" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ion Channels |
| Discussion Leader: Rachelle Gaudet (Harvard University) |
7:30 pm - 7:55 pm | Eduardo Perozo (University of Chicago)
"Structural basis of activation and deactivation gating in CorA: A Mg2+-dependent Mg2+ channel" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:40 pm | Richard Aldrich (UT, Austin) "Potassium channel gating by calcium." |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | David Julius (UCSF) "From peppers to pit vipers: molecular analysis of thermosensation and pain" |
9:15 pm - 9:25 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Emerging Methods in Membrane Transport |
| Discussion Leader: Mario Amzel (Johns Hopkins) |
9:00 am - 9:25 am | Katie Henzler-Wildman (Washington University, Saint Louis) "Direct observation of two-state exchange in asymmetric antiparallel EmrE: experimental evidence for a unique transport mechanism" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jose Faraldo-Gomez (Max Planck, Frankfurt) "Ion specificity and transport mechanism of rotary ATPases" |
10:00 am - 10:10 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:55 am | Hassane Mchaourab (Vanderbilt University) "Conformational Dynamics of LeuT" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Andrea Bruggeman (Nanion Technologies) "A lively view of KCSA" |
11:30 pm - 11:40 pm | Discussion |
11:40 am - 11:55 am | Daniel Basilio (Cornell Univeristy Medical School)
"Trapping a translocating protein within the anthrax toxin channel: implications for the secondary structure of permeating proteins" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Susan Harrington (Tel Aviv University)
"Proposed multiple states and motion in EmrE with functional interpretations based on a novel structure and motion prediction algorithm" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Hot Topics in Membrane Transport |
| Discussion Leader: Olga Boudker (Weill Cornell Medical School) |
7:30 pm - 7:45 pm | Ryan Hibbs (Vollum Institute)
"Structural basis of activation and permeation in an anion-selective Cys-loop receptor" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Rickard Blunck (University of Montreal)
"Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Scott Blanchard (Weill Cornell Medical School) "Single-molecule dynamics of gating in a neurotransmitter transporter homolog" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Poul Nissen (Aarhus University) "New views of the mechanisms of P-type ATPase ion pumps" |
9:10 pm - 9:20 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ABC Transporters |
| Discussion Leader: Jue Chen (Purdue University) |
9:00 am - 9:25 am | Dirk Slotboom (Univ. Groningen) "Structure and mechanism of vitamin transporters" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Amy Davidson (Purdue University) "Structure, function and conformational change in the ABC maltose transporter" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:55 am | Robert Tampe (Johann Wolfgang Goethe-University, Frankfurt) "Molecular Mechanism of ABC Transporters in Immunity and Viral Evasion" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Kasper Locher
(ETH, Zurich) "Mechanism of type II ABC importers" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Liz Carpenter (Structural Genomics Consortium, Oxford, UK)
"A Pipeline for Structural Biology of Human Integral Membrane Proteins: Starting at ABC" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Markus Seeger (University of Zurich)
"Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transport Mechanisms and Human Disease |
| Discussion Leader: Nancy Carrasco (Albert Einstein College of Medicine) |
7:30 pm - 7:55 pm | Rich Reimer (Stanford University) "Mechanisms underlying the pH dependence of sialin" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | T.C. Hwang (University of Missouri, Columbia)
"Unintelligent design of CFTR chloride channel gating" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Vito Verselis (Albert Einstein College of Medicine) "Aberrant Cx26 hemichannel function and keratitis-ichthyosis-deafness syndrome." |
9:10 pm - 9:20 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |