Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | ABC Transporters |
| Discussion Leader: Hassane Mchaourab (Vanderbilt University, USA) |
7:40 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:15 pm | Clemens Glaubitz (Goethe University Frankfurt, Germany) "New Functional Details of ABC Exporter MsbA Revealed by Solid-State NMR" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:55 pm | Oded Lewinson (Technion - Israel Institute of Technology, Israel) "Uncoupled ATP Hydrolysis by
ABC Transporters: Is There Some Hidden Purpose?" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Xiaolong Gao (University of Missouri-Columbia, USA) "Probing CFTR's Gate and Pore" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Emerging Methods in Membrane Transport Research |
| Discussion Leader: Simon Newstead (University of Oxford, United Kingdom) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | William Degrado (University of California, San Francisco, USA) "Analysis and Design of Proton Transporters" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Edmund Kunji (MRC - Mitochondrial Biology Unit, United Kingdom) "Defining the Transport States of Mitochondrial Carriers and Uncoupling Proteins by Using Thermostability Assays" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:40 am | Ban-Seok Jeong (Emory University, USA) "Direct Observation of M2 Proton Channel Activation Triggered by Rapid pH-jump" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:10 am | Coffee Break |
11:10 am - 11:40 am | Debora Marks (Harvard Medical School, USA) "Alternative Conformations of Membrane Proteins from Evolutionary Couplings" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Dimitrios Stamou (University of Copenhagen, Denmark) "Proton Pumping and Slippage Dynamics of a Eukaryotic P-ATPase Studied at the Single-Molecule Level" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Jacob Morgan (University of Virginia, USA) "Mechanism of Membrane Transport in Synthase-Dependent Polysaccharide Secretion" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ion-Motive ATPases |
| Discussion Leader: Miguel Holmgren (National Institute of Neurological Disorders and Stroke, NIH, USA) |
7:30 pm - 8:00 pm | Karen Davies (Max-Planck-Institute for Biophysics, Germany) "Structure of a Mitochondrial ATP Synthase Dimer" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Benoit Roux (University of Chicago, USA) "Structure and Energetics of the Ion Pumping Mechanism of Membrane ATPases" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Rajini Rao (Johns Hopkins University School of Medicine, USA) "Calcium at the Pump: Secretory Pathway Ca2+-ATPases in Mammary Physiology and Breast Cancer" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Symporters and Uniporters |
| Discussion Leader: Shimon Schuldiner (Hebrew University, Israel) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Gary Rudnick (Yale University, USA) "Activity-Dependent Regulation of Serotonin Transporter - Conformational Change and Phosphorylation" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Michael Grabe (University of California, San Francisco, USA) "Insight into Ion and Substrate Release from an Ensemble of Spontaneous Unbinding Events" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Frans Bianchi (University of Groningen, The Netherlands) "Asymmetry in Amino Acid Binding to Inward- and Outward-Facing Conformation of Lyp1 Explains the Apparent Unidirectionality of Transport" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Osamu Nureki (University of Tokyo, Japan) "Structural Basis for Rocker Switch or TM-Bending Mechanism of Transporters" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Dirk Jan Slotboom (University of Groningen, The Netherlands) "Pnu Transporters: Ain't They SWEET?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lipid Transport |
| Discussion Leader: Todd Graham (Vanderbilt University, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Pattama Wiriyasermkul (Columbia University, USA) "Interaction of Lipoic Acid with the Sodium/Multivitamin Transporter" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Robert Molday (University of British Columbia, Canada) "Lipid Flippases - Linking Structure and Transport
Mechanisms to Cell Function and Disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Kaspar Locher (ETH Zurich, Switzerland) "Mechanism
of ABC-Transporter-Catalyzed Lipid-Linked
Oligosaccharide Flipping" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Exchangers/Antiporters |
| Discussion Leader: Jose Faraldo-Gomez (National Heart, Lung and Blood Institute, NIH, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | Merritt Maduke (Stanford University, USA) "Conformational Dynamics of CLC Transporters" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Cedric Govaerts (Free University of Brussels, Belgium) "Molecular Basis of Secondary Multidrug Transport" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:15 am | Fabrizio Marinelli (National Heart, Lung and Blood Institute, NIH, USA) "Ion Occupancy Shapes Conformational Free-Energy Landscape of a Na+/Ca2+ Exchanger and Allosterically Controls Its Alternating-Access Mechanism" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:55 am | Carola Hunte (University of Freiburg, BIOSS, Germany) "Structure and Modulated Transport Activity of Sodium/Proton Antiporters" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Anne Robinson (Washington University, USA) "Protonation States of EmrE: Active Site Asymmetry and the Coupling Mechanism" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Elevator Mechanisms |
| Discussion Leader: Dirk Jan Slotboom (University of Groningen, The Netherlands) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:05 pm | Olga Boudker (Weill Cornell Medical College, USA) "Structure and Dynamics of Glutamate Transporters" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:30 pm | Amanda Scopelliti (University of Sydney, Australia) "Molecular Mechanisms of the Neutral Amino Acid Transporters, ASCTs" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Christopher Mulligan (National Institutes of Health, USA) "Life's Ups and Downs: the Transport Mechanism of the Succinate Transporter, VcINDY" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Oezkan Yildiz (Max Planck Institute of Biophysics, Germany) "Complete Mechanism of Na+-Dependent Citrate Transport from the Structure of an Asymmetrical CitS Dimer" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ligand-Gated Channels |
| Discussion Leader: Ramon Latorre (University of Valparaiso, Chile) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Andrew Marks (Columbia University, USA) "Structure of a Mammalian Ryanodine Receptor" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Andrew Plested (Leibniz Institute for Molecular Pharmacology, Germany) "Activation of Glutamate Receptor Ion Channel Complexes" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:40 am | Paul Shaffer (Amgen, Inc., USA) "Taking the Pain Out of Ion Channels" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:10 am | Coffee Break |
11:10 am - 11:40 am | Eduardo Perozo (University of Chicago, USA) "Structure and Dynamics of Magnesium Channels" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Crina Nimigean (Weill Cornell Medical College, USA) "Molecular Gate Location in Calcium-Activated Potassium Channels" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Unusual Channels and Scramblases |
| Discussion Leader: Alessio Accardi (Weill Cornell College of Medicine, USA) |
7:30 pm - 8:00 pm | Criss Hartzell (Emory University, USA) "The Phospholipid Scrambling and Ion Channel Functions of TMEM16/ANO Proteins" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Simone Pifferi (SISSA - International School for Advanced Studies, Italy) "Conditional Knockout of TMEM16A/Anoctamin1 Abolishes the Calcium-Activated Chloride Current in Mouse Vomeronasal Sensory Neurons" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Mattia Malvezzi (Weill Cornell Medical College, USA) "Sizing up the Lipid Pathway in a TMEM16 Phospholipid Scramblase" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Randy Stockbridge (Brandeis University, USA) "X-Ray Crystal Structure of a Dual Topology Fluoride Channel" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |