Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structure and Mechanisms of ABC Transporters
Discussion Leader: Heather Pinkett (Northwestern University, USA)
7:40 pm - 8:05 pm
Jochen Zimmer (University of Virginia School of Medicine, USA)
"ABC Transporters Implicated in Biopolymer Translocation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Maofu Liao (Harvard Medical School, USA)
"Cryo-EM Studies of an ATP-Binding Cassette Lipid Transporter"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Konstantinos Beis (Imperial College London, United Kingdom)
"Structural Basis for Antibacterial Peptide Self-Immunity by Bacterial ABC Transporters"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Zachary Johnson (The Rockefeller University, USA)
"Cryo-EM Snapshots of Substrate Recognition by the Multidrug Resistance Transporter MRP1"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Forefront of Structural Biology of Transport
Discussion Leader: Crina Nimigean (Weill Cornell Medicine , USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Eric Gouaux (Vollum Institute, Oregon Health and Science University, USA)
"Structure and Mechanism of Neurotransmitter Sodium Symporters"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Robert Tampe (Goethe-University Frankfurt, Germany)
"Antigens on the Move – New Twists and Turns in Adaptive Immunity"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Cameron Noland (Genentech, USA)
"Structural Insights into Bacterial Lipoprotein Biosynthesis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Vera Moiseenkova-Bell (Case Western Reserve University, USA)
"New Insight into the Structure of TRPV Channels"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Huaizong Shen (Tsinghua University, China)
"Structure of a Eukaryotic Voltage-Gated Sodium Channel at Near Atomic Resolution"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Altin Sula (Birkbeck, University of London, United Kingdom)
"The Complete Structure of an Activated Open Voltage Gated Sodium Channel Reveals a Novel Gating Interaction Motif"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Rajini Rao (Johns Hopkins University, USA) and Karen Fleming (Johns Hopkins University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Living in the Lipid Bilayer
Discussion Leader: Cedric Govaerts (Free University of Brussels, Belgium)
7:30 pm - 7:55 pm
Christine Ziegler (University of Regensburg, Germany)
"Impact of Specific Lipids on Membrane Transport, Two Sides of the Same Coin?"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Janice Robertson (The University of Iowa, USA)
"Measuring the Free Energy of ClC-ec1 Dimerization in Membranes Using Single-Molecule Photobleaching Analysis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Arthur Laganowsky (Texas A&M University, USA)
"Probing Membrane Protein-Lipid Interactions by Native Ion Mobility Mass Spectrometry"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Shannon Mostyn (University of Sydney, Australia)
"Heads or Tails: Lipid Inhibitors of the Glycine Transporter, GlyT2"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure, Dynamics and Mechanisms of Secondary Transporters
Discussion Leader: Merritt Maduke (Stanford University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Joseph Mindell (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Multimodal Approach to Understanding clc-7 Function in Lysosomes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Nicolas Reyes (Institut Pasteur , France)
"Structural and Dynamic Studies of Excitatory Amino Acid Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
David Drew (Stockholm University, Sweden)
"Lipids and Proton Transport in Na+/H+ Antiporters"
10:40 am - 10:50 am
Discussion
10:50 am - 11:20 am
Group Photo / Coffee Break
11:20 am - 11:45 am
Susan Buchanan (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Structural Insight into the Role of the Ton Complex in Transport Across the Outer Membrane"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Jeff Abramson (University of California, Los Angeles, USA)
"Deciphering Ligand Induced Conformational Changes in the Sodium Galactose Transporter (SGLT)"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Interactions with Membrane Proteins
Discussion Leader: Shimon Schuldiner (Hebrew University of Jerusalem, Israel)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Katherine Henzler-Wildman (University of Wisconsin-Madison, USA)
"EmrE Sacrifices Coupling Efficiency to Achieve Multidrug Promiscuity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Nate Traaseth (New York University, USA)
"Probing the Structure and Ion-Coupled Mechanism of the Multidrug Transporter EmrE Using NMR Spectroscopy"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Gerard Huysmans (Weill Cornell Medicine, USA)
"Exploring Protein Sequence Information Across Nature's Hot and Cold Habitats to Understand the Functional Dynamics in the Glutamate Transporter Family"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Thomas Stockner (Medical University of Vienna, Austria)
"Oligomer Interfaces of the Human Dopamine Transporter"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Energy Landscapes of Membrane Transport Proteins
Discussion Leader: Dirk Jan Slotboom (University of Groningen, The Netherlands)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Emad Tajkhorshid (University of Illinois at Urbana-Champaign, USA)
"Multidimensional Free Energy Landscape Governing Structural Transitions of a Neurotransmitter Transporter in Membrane"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jose Faraldo-Gomez (National Institutes of Health, USA)
"The Dos and Don'ts of Active Transporters: An Energy Landscape Perspective"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Scott Blanchard (Weill Cornell Medical College, USA)
"Imaging Functional Dynamics Within Individual Transporter Proteins Using Single-Molecule FRET"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Baron Chanda (University of Wisconsin-Madison, USA)
"Single Molecule Studies Reveal Ligand Binding Dynamics in Pacemaker Ion Channels"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Karen Fleming (Johns Hopkins University, USA)
"Driving Forces for Folding Membrane Proteins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Ligand-Gated Channels: Recent Updates
Discussion Leader: Lucy Forrest (National Institute of Neurological Disorders and Stroke, NIH, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Sudha Chakrapani (Case Western Reserve University, USA)
"Allosteric Mechanisms Underlying Pentameric Ligand-Gated Ion Channel Modulation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Visanthi Jayaraman (University of Texas Health Science Center at Houston, USA)
"Structure and Energy Landscapes of Ionotropic Glutamate Receptor"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Weronika Stanek (University of Groningen, The Netherlands)
"Competition Between S-Components for a Common Energizing Module"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ion Channels: Structure and Function
Discussion Leader: Eduardo Perozo (University of Chicago, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Show-Ling Shyng (Oregon Health and Science University, USA)
"Insights into the Mechanisms of KATP Channel Assembly and Gating from Cryo-EM Structures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Liz Carpenter (University of Oxford, United Kingdom)
"Structures of K2P and TRPP Channels by X-Ray, xFEL and Cryo-EM"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Alexander Sobolevsky (Columbia University, USA)
" Studies of the Epithelial Calcium Channel TRPV6"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Lucie Delemotte (Science for Life Laboratory, Sweden)
"Exploring the Complex Dynamics of an Ion Channel Voltage Sensor Domain via Computation"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Marina Diskowski (Goethe University Frankfurt, Germany)
"Helical Jackknives Control the Double-Pore K+ Uptake System KtrAB"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Valeria Vasquez (University of Tennessee Health Science Center, USA)
"Omega-3 Polyunsaturated Fatty Acids Enhance Human Endothelial Cells Response by Recruiting Transient Receptor Potential Channels"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Personalized Medicine: Disease-Causing Mutations in Channels and Transporters
Discussion Leader: Ute Hellmich (Johannes Gutenberg University of Mainz, Germany)
7:30 pm - 7:55 pm
Aurelio Galli (Vanderbilt University, USA)
"Failure to Prime the Dopamine 'Pump' in Autism"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Gaia Novarino (Institute of Science and Technology, Austria)
"Mutations in the Neutral Amino Acid Transporter LAT1 Are a Cause of Microcephaly and Autism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Hanne Poulsen (Aarhus University, Denmark)
"Murphy's Law of the Sodium Pump"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure