Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Interplay Between Proteins and Membranes
Discussion Leader: Vera Moiseenkova-Bell (Perelman School of Medicine, University of Pennsylvania, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:20 pm
Alessio Accardi (Weill Cornell Medicine, USA)
"Structural Basis of Calcium-Dependent Phospholipid Scrambling by TMEM16 Proteins"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Chloe Martens (King's College London, United Kingdom)
"How Direct Protein-Lipid Interactions Shape the Conformational Landscape of Secondary Transporters"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Cristina Paulino (University of Groningen, The Netherlands)
"The Flips and Flops of a Scramblase story: Insights into the Activation and Transport Mechanism of TMEM16 Proteins"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Linking Transport and Metabolism
Discussion Leader: Christine Ziegler (University of Regensburg, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Rachelle Gaudet (Harvard University, USA)
"Mechanics of Transition Metal Ion Transport by an Nramp Transporter"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Qiang Zhou (Westlake University, China)
"Structure of the Human LAT1-4F2hc Heteromeric Amino Acid Transporter Complex"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
Selected from Poster Abstracts: Philipp Bräuer (University of Oxford, United Kingdom)
"Structural Basis for pH-Dependent Retrieval of ER Proteins from the Golgi by the KDEL Receptor"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
Bert van den Berg (Newcastle University, United Kingdom)
"Outer Membrane Nutrient Processosomes in Dominant Human Gut Bacteria"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Ruth Cohen Khait (University of Oxford, United Kingdom)
"Translocation Mechanisms of Protein-Antibiotics"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Inga Hänelt (Goethe-University Frankfurt, Germany)
"Of Channels and Transporters: Potassium Uptake in Bacterial Survival"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Renae Ryan (University of Sydney, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
ABC Transporters in Health and Disease
Discussion Leader: Robert Tampé (Goethe University Frankfurt, Germany)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Kaspar Locher (ETH Zurich, Switzerland)
"Insight into Drug Transport and Small-Molecule Inhibition of Human ABCB1 and ABCG2"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Damian Ekiert (New York University School of Medicine, USA)
"Architectures of Lipid Transport Systems for the Bacterial Outer Membrane"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Selected from Poster Abstracts: Dovile Januliene (Max Planck Institute of Biophysics, Germany)
"Conformational Space of a Heterodimeric ABC Exporter Under Turnover Conditions"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Hassane Mchaourab (Vanderbilt University, USA)
"Mechanism of Allosteric Regulation of P-Glycoprotein"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ion Channels: From Atom to Animal
Discussion Leader: Sudha Chakrapani (Case Western Reserve University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Richard Hite (Memorial Sloan Kettering Cancer Center, USA)
"Structural Titration of Human IP3 Receptors Reveals Mechanisms of Ligand-Dependent Gating"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Crina Nimigean (Weill Cornell Medicine, USA)
"Lipid Modulation of CNG Channels"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 10:55 am
Selected from Poster Abstracts: Scott Hansen (The Scripps Research Institute, USA)
"A Molecular Basis for Membrane Mediated Inhaled Anesthesia"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
Isabelle Baconguis (Vollum Institute, Oregon Health and Science University, USA)
"Architecture of the Proteolysis-Regulated Epithelial Sodium Channel"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Ute Hellmich (Johannes Gutenberg University Mainz, Germany)
"Structural Basis of Dynamic TRP Channel Interaction with Lipids, Proteins and Cations"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Poul Nissen (Aarhus University, Denmark)
"Structure and Mechanism of P4-ATPase Lipid Flippases"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Folding in the Membrane
Discussion Leader: Karen Fleming (Johns Hopkins University, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Paula Booth (King's College London, United Kingdom)
"Co-Translational Folding of Major Facilitator Superfamily Transporters"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Francis Valiyaveetil (Oregon Health and Science University, USA)
"Functional Mechanisms in Channels and Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Selected from Poster Abstracts: Georgina Gáspárné Csizmadia (Semmelweis University, Hungary)
"Defining Membrane Boundaries of Proteins Using Electron Density Maps: The MemBlob Database and Server"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ian Collinson (University of Bristol, United Kingdom)
"How ATP Control of Pre-Protein Folding and the PMF Help Drive Protein Transport Across Membranes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Design and Evolution of Function
Discussion Leader: Jose Faraldo-Gomez (National Institutes of Health, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Michael Grabe (University of California, San Francisco, USA)
"Simulating Alternating Access of Sodium Symporters"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Dirk Jan Slotboom (University of Groningen, The Netherlands)
"Structural and Mechanistic Diversity of Vitamin B12 Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Merritt Maduke (Stanford University, USA)
"Structure of an Intermediate in the CLC Transport Cycle"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Selected from Poster Abstracts: Georg Kuenze (Vanderbilt University, USA)
"Personalized Structural Biology of the Voltage-Gated KCNQ1/KCNE1 Potassium Channel"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Randy Stockbridge (University of Michigan, USA)
"Evolution of Drug Export in the Small Multidrug Resistance Family"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Syma Khalid (University of Southampton, United Kingdom)
"Focusing the Computational Microscope on the Cell Envelopes of Gram-Negative Bacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Technologies for Uncovering Mechanistic Insight
Discussion Leader: Katherine Henzler-Wildman (University of Wisconsin-Madison, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Chris Ahern (University of Iowa, USA)
"Function and Pharmacology of Voltage-Gated Ion Channels"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Selected from Poster Abstracts: Gianmarco Meier (University of Zurich, Switzerland)
"Exploring a Multidrug Efflux Transporter by Deep Mutational Scanning"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Andre Heuer (Salipro Biotech, Sweden)
"The Salipro System for Stabilization of Membrane Proteins"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Jacob Keller (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Probing SERT Function with a Serotonin Biosensor"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Transporters and Channels Impacting Health and Disease
Discussion Leader: Gary Rudnick (Yale University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Nancy Carrasco (Yale School of Medicine, USA)
"An Allosteric Oxyanion Binding Site Controls Na+/I- Symporter (NIS) Transport Stoichiometry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Kenton Swartz (National Institutes of Health, USA)
"Molecular Mechanisms of P2X3 Receptor Channel Activation and Modulation by Divalent Cation Bound ATP"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Renae Ryan (University of Sydney, Australia)
"The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Jian Payandeh (Genentech, Inc., USA)
"How Toxins Modify Sodium Channels"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Ryan Hibbs (University of Texas Southwestern Medical Center, USA)
"Nicotinic Receptor Reconstitution and Structure"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Heather Young (University of Illinois at Urbana-Champaign, USA)
"Import Mechanism of the Human Serotonin Transporter Revealed Through Mutational and Computational Energy Landscapes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Concepts in Membrane Transport Biology
Discussion Leader: Jochen Zimmer (University of Virginia School of Medicine, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Selected from Poster Abstracts: Qinrui Wang (University of Oxford, United Kingdom)
"Understanding Protein-Lipid Interactions in a Ciliary Membrane TRP Channel"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
Eduardo Perozo (University of Chicago, USA)
"Cryo-EM Structures of MscS in a Lipid Bilayer and the Molecular Basis of 'Force from Lipids' Gating in Mechanosensitive Channels"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Selected from Poster Abstracts: Athanasia Kourkoulou (National and Kapodistrian University of Athens, Greece)
"Role of Lipids in Dimer Formation of a Purine Transporter"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Christopher Miller (Brandeis University, USA)
"How One Strong H-Bond Screws up a Transporter"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure