Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Modulation of Membrane Transport by Lipids and Ligands
Discussion Leader: Vedrana Mikusevic (Goethe University Frankfurt, Germany)
3:45 pm - 3:55 pm
Luis Romero (University of Tennessee Health Science Center, USA)
"Dietary Fatty Acids Fine-Tune Piezo1 Mechanical Response"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Bing Zhang (University of Basel, Switzerland)
"Structure and Mechanism of a Cell Wall Teichoic Acids Flippase"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Shashank Pant (University of Illinois at Urbana-Champaign, USA)
"Modulation of Orientational Dynamics of Excitatory Amino Acid Transporter-1 by Cholesterol"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bridging the Link Between Membrane Protein Structure and Dynamics / Unequal Numbers in STEM Transport
Discussion Leaders: Ruth Cohen Khait (University of Oxford, United Kingdom) and Kasturi Roy (Yale School of Medicine, USA)
7:30 pm - 7:55 pm
Georgios Skiniotis (Stanford University, USA)
"Cryo-EM Insights into GPCR Activation and Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Vanessa Clerico Mosina (University of Groningen, The Netherlands)
"Stepwise Activation Mechanism of the Scramblase nhTMEM16 Revealed by Cryo-EM"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Charlott Stock (Goethe Universität Frankfurt, Germany)
"Cryo-EM Structures of KdpFABC Reveal K+ Transport Mechanism via Two Inter-Subunit Half-Channels"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Heather Young (University of Illinois at Urbana-Champaign, USA)
"Mutational and Computational Landscapes Reveal the Import Mechanism of the Human Serotonin Transporter"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Karen Fleming (Johns Hopkins University, USA)
"Unequal Numbers in STEM Transport"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Membrane Transporters and Channels in Human Diseases / Systems on the Fringe: Appreciating Underappreciated Methodologies
Discussion Leaders: Wenlei Ye (University of California, San Francisco, USA) and Matthew Johnson (The Australian National University, Australia)
9:00 am - 9:15 am
Ruth Pumroy (University of Pennsylvania, USA)
"Molecular Mechanism of TRPV2 Channel Activation by Cannibidiol"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Gurdeep Minhas (University of Oxford, United Kingdom)
"Structural Basis for Prodrug Recognition by the SLC15 Family of Proton-Coupled Peptide Transporters"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Alisa Garaeva (University of Groningen, The Netherlands)
"A One-Gate Elevator Mechanism for the Human Neutral Amino Acid Transporter ASCT2"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Michael Clark (University of Chicago, USA)
"The Cryo-EM Structure of a Hyperpolarization-Activated Ion Channel: A Molecular Mechanism of Electromechanical Coupling"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Gabriel Fitzgerald (Weill Cornell Medicine, USA)
"Single-Molecule Recordings of Secondary Transporter Activity with Single-Turnover Resolution"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Shantanu Shukla (University of Tennessee, USA)
"Accessing Ligand-Induced Dynamics in ABC Transporter Associated Binding Proteins Using Neutron Scattering and Computational Methods"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
Discussion Leaders: Maria Falzone (Graduate School of Medical Sciences, Weill Cornell Medicine, USA) and Wenchang Zhou (National Heart, Lung and Blood Institute, NIH, USA)
1:30 pm - 2:30 pm
Panel Discussion
Risks, Pitfalls and Challenges in Research: Balancing Creativity and Pragmatism in a Competitive Scientific Environment
Shai Silberberg (National Institute of Neurological Disorders and Stroke, NIH, USA)
Randy Stockbridge (University of Michigan, USA)
Cristina Paulino (University of Groningen, The Netherlands)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes