Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Membrane Transport in the Complex Environment of the Cell
Discussion Leader: Krishna Reddy (Weill Cornell Medical College, United States)
3:15 pm - 3:25 pm
Fiona Fitzpatrick (Harvard School of Public Health, United States)
"Modulation of Mitochondrial NAD Uptake by SLC25A51"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
John Cowgill (Stockholm University, Sweden)
"Structure and Dynamics of Differential Ligand Binding in the Human P-Type GABAA Receptor"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Shawn Lamothe (University of Alberta, Canada)
"Subunit Stoichiometry and PIP2 Regulation of Allosteric Activators and Inhibitors of Kv7 Channels"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Mechanisms and Modulation of Membrane Transport
Discussion Leader: Anna Borowska (University of Groningen, The Netherlands)
5:30 pm - 5:45 pm
Ali Kusay (Linköpings Universitet, Sweden)
"Unique Lipid-Protein Interaction Fingerprints for the Kv7 Ion Channels"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Alannah King (University of Cambridge MRC MBU, United Kingdom)
"Pseudosymmetry Analysis as a Method to Identify Residues involved in Substrate Binding and Transporter Mechanisms from Sequence Information Alone"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Nathan Bernhardt (National Heart, Lung, and Blood Institute, United States)
"Lipid Modulation of Membrane Protein Conformational Equilibria does not Require Lipid Immobilization in Long-Lasting Protein-Lipid Complexes"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:35 pm
Introduction by Discussion Leader
6:35 pm - 7:20 pm
Nieng Yan (Shenzhen Medical Academy of Research and Translation (SMART) / Tsinghua University, China)
"Targeting Nav Channels for Drug Discovery"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Linking Structure, Function and Dynamics of Membrane Transporters and Channels
Discussion Leader: Smruti Nayak (Indian Institute of Science (IISc) Bangalore, India, India)
9:00 am - 9:15 am
Manan Bhatt (University of Insubria (NeuroTrans MSCA ITN), Italy)
"Betaine: A Substrate and the GABA Modulator of GAT1"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Patience Ngozi Paul (Florida International University, United States)
"The ArsQ Permease and Transport of the Arsenic-containing Antibiotic Arsinothricin (AST)"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Nayanika Sengupta (Indian Institute of Science, Bangalore, India)
"Single Particle Cryo-EM Unravels EspB as a Membrane Binding Effector of the Mycobacterial Type VII Secretion System"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Martin McAndrew (University of Warwick, United Kingdom)
"Predicting Type VII ABC Transporter Extracytoplasmic Binding Partners: From in Silico Prediction to Benchtop Validation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Jacob Hilton (National Institutes of Health, United States)
"Mechanism of ClC-7 Transporter Inhibition by the Lysosomal Phospholipid PI(3,5)P2"
10:35 am - 10:40 am
Discussion
10:40 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: How to Define Priorities and Juggle Professional and Personal Values as a Successful Scientist
Discussion Leader: Bryce Delgado (Memorial Sloan Kettering Cancer Center, United States)
1:30 pm - 1:40 pm
Introduction by Discussion Leader
1:40 pm - 2:25 pm
Olga Boudker (Weill Cornell Medicine, United States)
"How to Define Priorities and Juggle Professional and Personal Values as a Successful Scientist"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes