Sunday, June 22
7:30 p.m. - 9:30 p.m. What yeast and bacterial genomes have taught us about pumps, channels. and transporters
Carolyn Slayman, Discussion Leader
- The inventory of transport proteins as predicted from the yeast genome sequence
- Andre Goffeau (University Catholique of Louvain)
- General discussion followed by coffee
- Whole genome comparisons of microbial transport
- Karen Ketchum (The Institute for Genomic Research)
- General discussion
Monday, June 23
9:00 a.m. - 12:30 p.m. Approaches to the structure of membrane proteins
Donald Engelman, Discussion Leader
- Architectural principles in helical membrane proteins
- Donald Engelman (Yale University)
- Three-dimensional structure of SR calcium ATPase
- Chikashi Toyoshima (Tokyo University)
- General discussion followed by coffee
- Paths to the structure of the Neurospora plasma membrane H+-ATPase
- Gene Scarborough (University of North Carolina)
- A molecular mechanism for energy coupling in a membrane transport protein, the lactose permease of Escherchia coli
- Ronald Kaback (University of California at Los Angeles)
- General discussion
4:30 p.m. - 6:00 p.m. Poster Session I
7:30 p.m. - 10:00 p.m. Molecular Basis of Cation Selectivity
David Perlin, Discussion Leader
- Changing specificity of cation binding in E. coli F0F1 ATPase: structural interpretations
-Robert Fillingame (University of Wisconsin)
- Molecular basis for the coupling ion selectivity of FIF, ATPases
-Peter Dimroth (Microbiologisches Institut, Zurich)
- General discussion followed by coffee
- Na, K-ATPase: amino acid residues important for cation transport and functional role of alpha isoforms
-Jerry Lingrel (University of Cincinnati)
- Helix packing and the organization of the transport site in calcium pumps
-N. Michael Green (National Institute of Medical Research, London)
- General discussion
Tuesday, June 24
9:00 a.m. - 12:30 p.m. Channels and channel-like transporters
Donald Hilgemann, Discussion Leader
- Mechanotransducing complexes in C. elegans
-Monica Driscoll (Center for Advanced Biochemistry and Medicine, Rutgers University)
- The P2X purine receptor family of ligand-gated ion channels
-Annmarie Surprenant (Glaxo Institute for Molecular Biology, Geneva)
- General discussion followed by coffee
- Na+ channel permeation: plumbing around in the P-region to unclog the pore
-Edward Moczydiowski (Yale University)
- Properties of chloride channels associated with glutamate transporters
-Michael Kavanaugh (Oregon Health Sciences University)
- General discussion
4:30 p.m. - 6:00 p.m. Poster Session I
7:30 p.m. - 10:00 P.M. Pumps
Jack Kaplan, Discussion Leader
- Amber suppression scanning mutagenesis of the K+ binding sites in the Kdp ATPase of E. coli
-Wolfgang Epstein (University of Chicago)
- New calcium transporters in yeast: insights into mechanism and regulation
-Rajini Rao (Johns Hopkins School of Medicine)
- General discussion followed by coffee
- Drs2, a novel P-Type ATPase in the yeast plasma membrane
-Hans Rudolph (University of Stuttgart)
- Human Cu++-transporting ATPases: structural features, tissue distribution, and metal-binding properties
-Svetiana Lutsenko (Oregon Health Sciences University)
- General discussion
Wednesday, June 25
9:00 a.m. - 12:30 p.m. Multidrug resistance proteins
Alan Senior, Discussion Leader
- The multidrug transporters in yeast
-Elisabetta Balzi (University Catholique of Louvain)
- Structure and mechanism of the human multidrug transporter
-David Clarke (University of Toronto)
- General discussion followed by coffee
- Structure and function of the multidrug resistance P-glycoprotein, an ABC transporter
-Christopher Higgins (University of Oxford)
- Drug transport medicated by a novel prokaryotic homolog of the human multidrug resistance protein
-Wil Konings (University of Groningen)
- General discussion
4:30 p.m. - 6:00 p.m. Poster Session II
7:30 p.m. - 10:00 p.m. Novel transporters
Gary Rudnick, Discussion Leader
- The multifunctional nature of the tetracycline efflux protein from Gram-positive bacteria
-Terry Krulwich (Mount Sinai School of Medicine)
- EmrE, the smallest ion-coupled transporter, provides a unique experimental system for structure-function studies
-Shimon Schuldiner (Hebrew University)
- General discussion followed by coffee
- Role of Nramp proteins in resistance to intracellular infections and in macrophage function
-Philippe Gros (McGill University)
- The thyroid sodium/iodine symporter
-Nancy Carrasco (Albert Einstein College of Medicine)
- General discussion
Thursday, June 26
9:00 a.m. - 12:30 p.m. Biogenesis and function of transporters
Ernest Wright, Discussion Leader
- SHU recruits amino acid permeases into COPII transport vesicles
-Per Ljungdahl (Ludwig Institute for Biomedical Research, Stockholm)
- The role of cytoplasmic proteases in the degradation of integral membrane proteins
-Ron Kopito (Stanford University)
- General discussion followed by coffee
- Deterininants of CFTR biosynthetic processing
-John Riordan (Mayo Clinic, Scottsdale)
- Domains of the Na-K-Cl cotransporter important in ion translocation and bumetanide inhibition
-Bliss Forbush, III (Yale University)
- General discussion
4:30 p.m. - 6:00 p.m. Poster Session II
7:30 p.m. - 8:00 p.m. Business Meeting
8:00 p.m. - 10:00 p.m. Genetic diseases of transport
Carolyn Slayman, Discussion Leader
- Mutations altering human blood pressure change salt homeostasis
-Richard Lifton (Yale University)
- General discussion
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