Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The State of Regulation in Microbial Systems
Discussion Leader: Sankar Adhya (National Cancer Institute, NIH, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:30 pm
Jeffrey Roberts (Cornell University, USA)
"A Historical Perspective on the Discovery of Sigma and the Structure of RNA Polymerase"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Mark Buttner (John Innes Centre, United Kingdom)
"c-di-GMP Arms an Anti-σ to Block Streptomyces Development"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Structural Basis of Microbial Transcription
Discussion Leader: Lucia Rothman-Denes (The University of Chicago, USA)
9:00 am - 9:25 am
Seth Darst (The Rockefeller University, USA)
"Structural Studies of the Bacterial Transcription Cycle"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Hande Boyaci Selcuk (The Rockefeller University, USA)
"Capturing Transcription Initiation Intermediates by Cryo-EM"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Xiaodong Zhang (Imperial College London, United Kingdom)
"Structures and Mechanisms of Sigma54-Dependent Transcription Initiation"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Richard Ebright (Rutgers University, USA)
"RNA Polymerase: The Molecular Machine of Transcription"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Katsuhiko Murakami (Pennsylvania State University, USA)
"Structural Study of Archaeal RNA Polymerase Transcription"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Deborah Hinton (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) and Scarlet Shell (Worcester Polytechnic Institute, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Initiation and Catalysis
Discussion Leader: Wilma Ross (University of Wisconsin-Madison, USA)
7:30 pm - 7:55 pm
Steve Busby (University of Birmingham, United Kingdom)
"Activation at Simple and Complex Bacterial Promoters"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Georgiy Belogurov (University of Turku, Finland)
"Sequence-Dependent Control of RNA Polymerase Translocation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Richard Gourse (University of Wisconsin-Madison, USA)
"Transcriptional Responses to ppGpp and DksA"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Liang Yin (University of Washington, USA)
"Bacterial Longevity Requires a Stringent Response and a General Stress Response Alternative Sigma Factor"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Elongation and Termination
Discussion Leader: Paul Babitzke (Pennsylvania State University, USA)
9:00 am - 9:25 am
Jingyi Fei (The University of Chicago, USA)
"Dynamic Interactions Between Hfq and RNA in Live Bacterial cells"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Ranjan Sen (Centre for DNA Fingerprinting and Diagnostics, India)
"The Transcription Terminator Rho, a Pleiotropic Controller of the Bacterial Physiology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Alexander Yakhnin (Pennsylvania State University, USA)
"Genome-Wide Identification of NusG-Dependent RNA Polymerase Pausing in B. subtilis "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Robert Landick (University of Wisconsin-Madison, USA)
"Structure-Function of Bacterial Transcription Elongation Complex Regulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Achillefs Kapanidis (University of Oxford, United Kingdom)
"In Vivo Super-Resolution Imaging of RNA Polymerase Organization and Its Coupling to Translation"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcription in Archaea, Mitochondria and Phage
Discussion Leader: Dmitry Temiakov (Thomas Jefferson University, USA)
7:30 pm - 7:55 pm
Smita Patel (Rutgers University, USA)
"Mechanism and Regulation of Mitochondrial RNA Polymerases"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Thomas Santangelo (Colorado State University, USA)
"The Archaeal Transcription Termination Factor FttA"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Fabian Blombach (University College London, United Kingdom)
"Post-Recruitment Regulation Modulates Transcription in Archaea Globally"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Hauke Hillen (Max Planck Institute for Biophysical Chemistry, Germany)
"Structural Basis of Transcription by a Viral Multisubunit RNA Polymerase"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulatory RNA Networks and Metabolic Control of Transcription
Discussion Leader: Scarlet Shell (Worcester Polytechnic Institute, USA)
9:00 am - 9:25 am
Gisela Storz (National Institute of Child Health and Human Development, NIH, USA)
"Astonishing Diversity and Redundancy in Small RNA-Mediated Regulation"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Gene-Wei Li (Massachusetts Institute of Technology, USA)
"Probing Co-Transcriptional Translation and RNA Processing in B. subtilis "
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Josh McQuail (Imperial College London, United Kingdom)
"An Unusual Feature in the Post-Transcriptional Landscape of Long-Term Nitrogen Starved Escherichia coli "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Shixin Liu (The Rockefeller University, USA)
"Prevalent Bidirectional Transcription Terminators Revealed by Full-Length RNA Profiling in Bacteria"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Joerg Vogel (Helmholtz Institute for RNA-Based Infection Research, Germany)
"Predicting In Vivo Complexes of Proteins and RNA by Grad-Seq"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Diagnostics and Antimicrobials
Discussion Leader: Richard Brennan (Duke University School of Medicine, USA)
7:30 pm - 7:55 pm
Maria Schumacher (Duke University, USA)
"Dissection of the Regulatory Circuitry Controlling Virulence in Francisella tularensis "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Grace Beggs (Duke University, USA)
"Interrogating the Role of MtrR from Neisseria gonorrhoaea in Gonococcal Stress Responses"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Irina Artsimovitch (Ohio State University, USA)
"Activation of Virulence Genes by NusG Paralogs"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Ann Hochschild (Harvard Medical School, USA)
"Transcription-Based Assays for Detecting Prion Formation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Virulence Genes
Discussion Leader: Joseph Wade (Wadsworth Center, New York State Department of Health, USA)
9:00 am - 9:25 am
Deborah Hinton (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Both c-di-GMP and Phosphorylation Regulate Activation of V. cholerae Biofilm Biogenesis Genes by the Atypical Enhancer Binding Protein VpsR"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Deepti Jain (Regional Centre for Biotechnology, India)
"Transcription Regulation of Flagellar Gene Expression in Pseudomonas aeruginosa "
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Nicholas Ragazzone (The University of Michigan, USA)
"Investigating the Shigella Master Transcriptional Regulator, VirF, as an Anti-Virulence Target"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Sean Crosson (Michigan State University, USA)
"Environmental Response Systems in Alphaproteobacteria"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Simon Dove (Boston Children's Hospital, USA)
"Co-Transcriptional Activities of Post-Transcriptional Regulators in Pseudomonas aeruginosa "
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcriptional Coupling to Chromosomal Processes
Discussion Leader: Terence Strick (École Normale Supérieure, France)
7:30 pm - 7:55 pm
Jade Wang (University of Wisconsin-Madison, USA)
"Resolving Transcription-Replication Conflicts"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
David Grainger (University of Birmingham, United Kingdom)
"Understanding Intragenic Transcription and Its Consequences"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Tina Liu (University of California, Berkeley, USA)
"Target Preference of Type III-A CRISPR-Cas Complexes at the Transcription Bubble"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Max Gottesman (Columbia University, USA)
"NusG Couples Transcription with Translation"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure