Saturday |
2:00 pm - 5:00 pm | Arrival and Check-in |
3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:45 pm - 5:45 pm | In Silico and In Vitro Methods for Lead Generation |
| Discussion Leader: Mary Mader (Eli Lilly and Company, USA) |
3:45 pm - 3:55 pm | Introduction by Discussion Leader |
3:55 pm - 4:25 pm | Thomas Simpson (Boehringer Ingelheim Pharmaceuticals, USA) "In Silico and In Vitro Methods for Assessment of Physicochemical Properties - What Makes a Good Lead?" |
4:25 pm - 4:40 pm | Discussion |
4:40 pm - 5:10 pm | Benjamin Pratt (Akarna Therapeutics, USA) "In Vitro Biology for the Medicinal Chemist" |
5:10 pm - 5:25 pm | Discussion |
5:25 pm - 5:45 pm | General Discussion |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Approaches to In Vitro Assessment of ADMET Properties of Lead Candidates |
| Discussion Leader: Michael Visser (Novartis, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:10 pm | Kimberly Cameron (Pfizer, Worldwide Medicinal Chemistry, USA) "In Vitro Pharmacokinetic Assays and Their Use in Drug Discovery" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:55 pm | Christopher Smith (COI Pharmaceuticals, USA) "Metabolic Clearance and Strategies to Overcome" |
8:55 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
9:45 pm - 11:00 pm | Poster Session |
Sunday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Assessment of In Vivo Pharmacokinetics, Efficacy and Safety During Lead Optimization |
| Discussion Leader: Matthew Marx (Marx Pharma Consulting, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | Margaret Chu-Moyer (Amgen, USA) "The Basics of Pharmacokinetics and Disease Models" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Antonia Stepan (Pfizer, USA) "Structural Alerts and Reactive Metabolites: A Medicinal Chemistry Perspective on How to Navigate this Minefield" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:00 am | General Discussion |
11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Case Study in Medicinal Chemistry |
| Discussion Leader: Robert Jacobs (Anacor Pharmaceuticals, USA) |
1:30 pm - 1:35 pm | Introduction by Discussion Leader |
1:35 pm - 2:15 pm | Matthew Bourbeau (Amgen, USA) "The Discovery of Disruptors of GK/GKRP Protein-Protein Interactions" |
2:15 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
3:00 pm | Seminar Concludes |