Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | How Do Membrane Proteins Insert into the Membrane? |
| Discussion Leader: James Bowie (University of California, Los Angeles, USA) |
7:40 pm - 8:05 pm | Thomas Miller (California Institute of Technology, USA) "Long-Timescale Simulation of Sec-Facilitated Protein Translocation and Membrane Integration" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Tomoya Tsukazaki (Nara Institute of Science and Technology, Japan) "Structures of Membrane Protein Insertase YidC" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Alexey Ladokhin (University of Kansas Medical Center, USA) "pH-Triggered Conformational Switching Along Membrane Insertion Pathways" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Gavin King (Univeristy of Missouri-Columbia, USA) "SecA-Lipid Interactions via Single Molecule Force Spectroscopy" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Beta Barrel Folding |
| Discussion Leader: Clifford Sandlin (Johns Hopkins University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | David Brockwell (The University of Leeds, United Kingdom) "Folding and Remodeling of Outer Membrane Proteins in the Periplasm of E. coli" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Xinsheng Zhao (Peking University, China) "The Proper Prefolding Form of OMPs in the Periplasm Is Extended" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:20 am | Natalia Carulla (IRB Barcelona, Spain) "Micelles Promote Aβ42 Assembly into Pore-Forming Oligomers" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Marcelo Sousa (University of Colorado, Boulder, USA) "Structure and Function of the Beta-Barrel Assembly Machine and Its Associated Chaperones" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Sebastian Hiller (University of Basel, Switzerland) "Mechanistic Aspects of Beta-Barrel Membrane Protein Folding" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Sarah McDonald (Johns Hopkins University, USA) "Aromatic Residues in Membrane Proteins: Living on the Edge of the Membrane and in the Face of Aromatic Nearest-Neighbor Interactions" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Johannes Thoma (ETH Zurich, Switzerland) "Direct Observation of Chaperone Modulated Outer Membrane Protein Folding" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Principles of Membrane Protein Design |
| Discussion Leader: Nicholas Woodall (University of California, Los Angeles, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Patrick Barth (Baylor College of Medicine, USA) "Uncovering and Reprogramming G Protein Coupled Receptor Signaling by Protein Design" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Tobin Sosnick (University of Chicago, USA) "Near-Atomic Level Membrane Protein Folding Simulations Using Depth- and Residue-Dependent Potentials" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Jie Liang (University of Illinois at Chicago, USA) "Generalized Transfer Free Energy Scales and Building Blocks of Beta Barrel Membrane Proteins and Implications in Folding" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Julia Koehler Leman (Johns Hopkins University, USA) "Development of RosettaMPdock: A Novel Computational Tool for Global Flexible Backbone Protein-Protein Docking in the Membrane Environment" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Topology Determination |
| Discussion Leader: Michael Sanders (Kings College London, United Kingdom) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | William Dowhan (University of Texas Medical School at Houston, USA) "Lipid-Protein Interactions as a Determinant of Membrane Protein Dynamic Organization" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Joanna Slusky (University of Kansas, USA) "Charge Asymmetry in Proteins of the Outer Membrane" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:20 am | Yuichiro Kida (University of Hyogo, Japan) "Stability of Marginally Hydrophobic Segments Stalling at the ER Translocon" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Gunnar Von Heijne (Stockholm University, Sweden) "Co-Translational Folding of Membrane Proteins Probed by Arrest-Peptide Mediated Force Measurements" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Douglas Theobald (Brandeis University, USA) "The Plastic Rhodopsin Fold: Constraint, Convergence, and Common Ancestry in the Evolution of Protein Architecture" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Ismael Mingarro (University of Valencia, Spain) "Transmembrane Helix Design" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Bil Clemons (California Institute of Technology, USA) "A Machine Learning Approach to Heterologous Membrane Protein Overexpression" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structure Prediction of Membrane Proteins |
| Discussion Leader: Bryan Berger (Lehigh University, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Charlotte Deane (University of Oxford, United Kingdom) "What's Special About Homology Modeling for Membrane Proteins?" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Alessandro Senes (University of Wisconsin-Madison, USA) "Analysis and Prediction of a Common Transmembrane Helix Interaction Motif" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Debora Marks (Harvard Medical School, USA) and Chris Sander (Memorial Sloan Kettering Cancer Center, USA) "Evolutionary Couplings to Determine 3D Structures and Conformational Changes of Membrane Proteins" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Matthias Buck (Case Western Reserve University, USA) "Protein Interactions in and at the Membrane: Computational Predictions and Their Validation for the Plexin Family of Single Transmembrane Receptors" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Folding and Dynamics |
| Discussion Leader: Antje Pokorny (University of North Carolina at Wilmington, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Wonpil Im (University of Kansas, USA) "CHARMM-GUI Tools for Membrane Protein Folding Simulation Studies" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Martin Ulmschneider (Johns Hopkins University, USA) "Peptide Folding onto and into Lipid Bilayers" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:20 am | Lynmarie Thompson (University of Massachusetts Amherst, USA) "The Role of Subdomain Stabilization/Destabilization in Chemotaxis Receptor Signaling Mechanisms: Hydrogen Exchange Measurements" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Francis Valiyaveetil (Oregon Health and Science University, USA) "Using In Vitro Folding to Investigate Membrane Proteins" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Tae-Young Yoon (Korea Advanced Institute of Science and Technology, South Korea) "Mapping the Energy Landscape for Second Stage Folding of a Single Membrane Protein" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Kvido Strisovsky (Institute of Organic Chemistry and Biochemistry (IOCB), Czech Republic) "Substrate Recognition and Reaction Mechanism of Rhomboid Intramembrane Protease GlpG" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Yongli Zhang (Yale University School of Medicine, USA) "Folding Intermediates, Energies, and Kinetics of Synaptic SNARE Complexes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Paths of Membrane Protein Folding |
| Discussion Leader: Tobin Sosnick (University of Chicago, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Ann Dixon (University of Warwick, United Kingdom) "Membrane Proteins by Any Means Necessary" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Daniel Otzen (Aarhus University, Denmark) "Folding of the Bacterial Membrane Protein GlpG In Vitro and In Silico: A Compact Nucleus and Frustrated Loops" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Shu-Ou Shan (California Institute of Technology, USA) "Mechanism of a Novel Membrane Protein Chaperone" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Robert Best (National Institutes of Health, USA) "Equilibrium Folding of Transmembrane Peptides via Enhanced Sampling" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Membrane Protein Structural Stability Determinants |
| Discussion Leader: Yinan Wei (University of Kentucky, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Janice Robertson (University of Iowa, USA) "Measuring the Free Energy of Dimerization of a CLC Cl-/H+ Antiporter in Membranes" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dieter Langosch (Technical University Munich, Germany) "The Conformational Dynamics of Transmembrane Helices" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:20 am | Heedeok Hong (Michigan State University, USA) "General Steric Trapping Strategy Reveals an Intricate Cooperativity Network in the Intramembrane Protease GlpG Under Native Conditions" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Isaiah Arkin (Hebrew University, Israel) "Why Are Transmembrane Proteins So Hydrophobic?" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Peter Tieleman (University of Calgary, Canada) "New Tools for Membrane Protein Simulations" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Francisco Barrera (University of Tennessee, USA) "Protein-Lipid Interactions Control the Membrane Insertion of the pH-Low Insertion Peptide" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Andrew Miranker (Yale University, USA) "Molecular Origins of Membrane Poration" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Membrane Protein Folding and Disease |
| Discussion Leader: Karen Fleming (Johns Hopkins University, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Amitabha Chattopadhyay (Center for Cellular and Molecular Biology, India) "GPCR-Cholesterol Interaction: Novel Insight in Health and Disease" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | John Riordan (University of North Carolina, USA) "CFTR Folding and Assembly" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Charles Sanders (Vanderbilt University, USA) "The Scarlet Letter: Membrane Protein Instability and Human Disease" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | General Discussion |
9:25 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |