Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
How Bilayer Composition Affects Membrane Proteins
Discussion Leader: Karen Fleming (Johns Hopkins University, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:20 pm
Erwin London (Stony Brook University, USA)
"Affect of Lipid Composition and Asymmetry in Artificial and Cell Membranes on Membrane Protein Structure and Function"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Janice Robertson (Washington University in St. Louis, USA)
"Tuning the Stability of CLC Dimers by Changing the Lipid Solvent"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Nicole Swope (University of Virginia, USA)
"Alpha-Helical Membrane Protein Folding in Bicelles and Micelles"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Endoplasmic Reticulum Quality Control and Misfolding of Membrane Proteins
Discussion Leader: Sheena Radford (University of Leeds, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Jeffrey Brodsky (University of Pittsburgh, USA)
"The Quality Control of Aggregation-Prone Membrane Proteins in the Endoplasmic Reticulum"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Randolph Hampton (University of California, San Diego, USA)
"Recognition of Misfolded Membrane Proteins in the ERAD Pathway"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Charles Kuntz (Indiana University, USA)
"Evaluating Biophysical Constraints on the Sequence of Rhodopsin by Deep Mutational Scanning"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Dmitry Veprintsev (University of Nottingham, United Kingdom)
"Potential Quality-Control Amino Acid Positions at the Surface of GPCRs"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Michael Cheetham (Institute of Ophthalmology, University College London, United Kingdom)
"The Affect of Retinitis Pigmentosa Mutations on Rhodopsin Biogenesis and Traffic"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Hui Huang (Vanderbilt University, USA)
"Stabilization of the KCNQ1 Potassium Channel Causes Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Karen Fleming (Johns Hopkins University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Engineering of Membrane Proteins
Discussion Leader: William Degrado (University of California, San Francisco, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
Patrick Barth (Ecole Polytechnique Federale de Lausanne, Switzerland)
"Computational Designed Membrane Receptor Quaternary Structures Bias Intracellular Signaling Pathway Activation"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
Peilong Lu (University of Washington, USA)
"Accurate Computational Design of Transmembrane Proteins"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Jeffrey Saven (University of Pennsylvania, USA)
"Membrane Protein Folding Without Membranes: Water Soluble Variants of Integral Membrane Proteins"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Rebecca Alford (Johns Hopkins University, USA)
" Protein Structure Prediction and Design in a Biologically-Realistic Implicit Membrane"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early Stages of Folding of Helical Membrane Proteins
Discussion Leader: Stephen White (University of California, Irvine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ian Collinson (University of Bristol, United Kingdom)
"Mechanism of Membrane Protein Insertion Through the Bacterial Holo-Translocon"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Linda Hendershot (St. Jude Children's Research Hospital, USA)
"Integration of Unusual TM Domains into ER Membranes"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Liz Miller (MRC Laboratory of Molecular Biology, United Kingdom)
"Co-Translational Quality Control of Membrane Protein Biogenesis"
11:25 am - 11:40 am
Discussion
11:40 am - 11:50 am
Ross Eaglesfield (University of Glasgow, United Kingdom)
"Protein-Inherent Co-Translational Ribosome Targeting Is Minimally Sufficient for Membrane Protein Insertion"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Ismael Mingarro (University of Valencia, Spain)
"Folding of Helices at the Early Stages of Membrane Protein Biogenesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Tobin Sosnick (University of Chicago, USA)
"Controlling the Folding and Misfolding of Potassium Channels"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Insight into Membrane Protein Folding and Interactions
Discussion Leader: Linda Columbus (University of Virginia, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Eamonn Reading (King's College London, United Kingdom)
"Advanced Mass Spectrometry to Probe Membrane Proteins in Native Membranes"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
William Clemons (California Institute of Technology, USA)
"Recognition of Tail-Anchored Membrane Proteins by SGTA/Sgt2"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Nir Fluman (Stockholm University, Sweden)
"Dynamic Membrane Topology in an Unassembled Membrane Protein"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Tracy Stone (Hospital for Sick Children, Canada)
"Lysine vs. Leucine: Interplay of Amphipathicity and Hydrophobicity in Peptide-Membrane Interactions"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteolysis in the Fates of Membrane Proteins
Discussion Leader: Alessandro Senes (University of Wisconsin-Madison, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Heedeok Hong (Michigan State University, USA)
"Folding-Degradation Relationships of a Helical-Bundle Membrane Protein"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Hyun Ah (Joy) Kim (Seoul National University, South Korea)
"Unexpected Roles of Signal Peptidase on Membrane Protein Biogenesis"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Sichen Shao (Harvard Medical School, USA)
"Mechanistic Insights into Tail-Anchored Protein Triage"
11:25 am - 11:40 am
Discussion
11:40 am - 11:50 am
Nicola Harris (King's College London, United Kingdom)
"Co-Translational Folding of Alpha Helical Membrane Proteins"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Nandhini Rajagopal (Syracuse University, USA)
" A High-Throughput Computational Method to Generate Energy Landscape of Transmembrane Protein Association"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Tae-Young Yoon (Seoul National University, South Korea)
"Watching Single Membrane Proteins Fold"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Coupling of Bilayer Properties to Membrane Protein Folding
Discussion Leader: Heather Findlay (King's College London, United Kingdom)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Daniela Albanesi (Institute of Molecular and Cell Biology of Rosario (IBR-CONICET) / National University of Rosario, Argentina)
"Temperature-Sensing in Membranes: Lessons Learned from DesK"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Ann Dixon (University of Warwick, United Kingdom)
"Revealing the Mechanism of Protein-Lipid Interactions for a Putative Membrane Curvature Sensor in Plant Endoplasmic Reticulum"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Dirk Schneider (Johannes Gutenberg University Mainz, Germany)
"How Membranes Govern Protein Folding and Activity"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shashank Srivastava (Indian Institute of Science Education and Research, India)
"Mapping the Folding Landscape of Human Mitochondrial Porin in Bilayer Membranes"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Linkages Between Folding and Function
Discussion Leader: Daniel Otzen (Aarhus University, Denmark)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Matthew Shurtleff (University of California, San Francisco, USA)
"The Endoplasmic Reticulum Membrane Protein Complex Engages Cotranslationally to Enable Multipass Membrane Protein Biogenesis"
9:35 am - 9:50 am
Discussion
9:50 am - 10:00 am
Wade Van Horn (Arizona State University, USA)
"Identifying the Contributions of the TRPV1 Membrane Domains to Thermosensing"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Birthe Kragelund (University of Copenhagen, Denmark)
"Single Pass Receptors: Simple but Not Simplistic"
11:00 am - 11:15 am
Discussion
11:15 am - 11:25 am
Victor Vasquez Montes (University of Kansas Medical Center, USA)
"Lipid-Mediated Folding and Insertion of Apoptotic Regulator Bcl-xL"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Matthew Call (Walter and Eliza Hall Institute for Medical Research, Australia)
"How TM Interactions Guide Receptor Structure and Regulation of Signaling in Immunity"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Huong Kratochvil (University of California, San Francisco, USA)
"Understanding the Mechanisms of Proton Transport Through the Design of a Proton Channel"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Folding of Beta Barrel Membrane Proteins
Discussion Leader: Radhakrishnan Mahalakshmi (Indian Institute of Science Education and Research, Bhopal, India)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Nils Wiedemann (University of Freiburg, Germany)
"Mitochondrial Membrane Protein Biogenesis: Pathways and Mechanisms"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Joanna Slusky (University of Kansas, USA)
"The Complex Evolution of Outer Membrane Proteins"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Matthew Doyle (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
" Bacterial Outer Membrane Proteins Assemble via Asymmetric Interactions with the BamA Beta-Barrel"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Matthew Watson (Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom)
"Single-Molecule FRET Evidence of an Intermembrane BAM-HTL Supercomplex"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure