Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Membrane Proteins in Disease
3:15 pm - 3:25 pm
"Ribosomal Frameshifting Selectively Modulates the Expression, Assembly, and Function of a Misfolded CFTR Variant"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
"Assessing KCNQ1 Stability and its Role in Long QT Syndrome"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"Uncovering the Mechanism of Potassium Channel Folding and Assembly"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Probing Membrane Protein Folding with Computational Approaches and Empirical Screening
5:30 pm - 5:40 pm
"Rules of Interaction: Contributions of Symmetry in Membrane Protein Function and Assembly"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Contacts Reveal the Barrel"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"De Novo Design of Hybrid Protein-Lipid Nanomaterials"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Probing Endoplasmic Reticulum Membrane Protein Complex (EMC) Recognition by Deep Mutational Scanning"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"High-Throughput Screening to Identify Modulators of Membrane Protein Raft Affinity in Giant Plasma Membrane Vesicles"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Computational Design of Multi-Domain Receptors with Programmable Sensing and Signaling Functions"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Computational Design and Cellular Production of a De Novo Transmembrane Cytochrome"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Exploring the Structure Function Landscape of the Human Sodium–Taurocholate Co-Transporting Polypeptide (NTCP)"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Effects of Lipids and Physical Forces on Membrane Proteins
9:00 am - 9:10 am
"Towards High-Throughput AFM-based Force-Spectroscopy Studies of Membrane Proteins Using Site-Specific Attachment"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Using HDX-MS To Probe The Dynamics and Denatured State of GlpG, a Helical Membrane Protein"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Mapping Out the Physical Driving Forces of Functional Assembly of the Fluoride Channel Fluc in Membranes"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Isolation of Endoplasmic Reticulum Subdomains from Mammalian Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Cotranslational Membrane Insertion of the Voltage-Gated Potassium Channel KvAP"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Lipid Bilayer Thickness Modulates the Folding Stability of Outer Membrane Phospholipase A"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Towards Mechanistic Understanding of Mitochondrial beta-barrel Biogenesis: Structural Studies of the Sorting and Assembly Machinery"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Tuneable Force-Transduction through the Escherichia Coli Periplasm"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Careers in Membrane Protein Folding
1:30 pm - 2:30 pm
Panel Discussion
Q&A Panel for Early Career Scientists
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes