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Registration 2:00-11:00 PM
Reception 5:00
Dinner 6:00
Session I
Sun 9 a.m -12:30 p.m. |
Introduction
Michael Kavanaugh, Vollum Institute
Overview of mammalian transporter families and Superfamilies
Matthias A. Hediger, Harvard University
Session I
Sun 9 a.m -12:30 p.m. | Renal Solute Transport |
(Matthias Hediger and Heini Murer, Discussion leaders)
The Pendred syndrome gene encodes a chloride-iodide transporter with functionally similarity to the renal chloride/formate exchanger
Lawrence P. Karniski, University of Iowa College of Medicine
The Type IIa Na/Phosphate Cotransporter: its Structure and Physiological Function
Heini Murer, University of Zurich
Short presentations
Studies on the Type II Na/Phosphate symporters Pit I and Pit II
Christine Salaun, Pasteur Institute
cDNA microanalysis of gene expression from kidneys of NHE3 knockout and Na+-depleted mice
Michael Flagella, University of Cincinnati College of Medicine
Session II
Sun 8 p.m. - 9 p.m | Keynote address |
Active Sugar Transport - Physiology, Pathophysiology and Proteomics
Ernest Wright, UCLA School of Medicine
Session III
Mon 9 a.m. - 12:30 p.m. | Membrane Proteins and Diabetes |
(Maureen Charron, Discussion leader)
ATP-Sensitive K Channels and Hypoglycemia of Infancy
Lydia Aguilar-Bryan, Baylor College of Medicine
Fatty Acid Transport and Fatty Acyl CoA Regulation of Membrane Proteins in ß-cells and Fat Cells
Barbara E. Corkey, Boston Medical Center
Glucose Transporter Cycling and Activation:Physiology in Need of Biochemistry
Amira Klip, Hospital for Sick Children, Toronto
GLUTx1, A Novel Glycemia-Sensitive Glucose Transporter: Molecular and Cellular Analysis
Maureen Charron, Albert Einstein College of Medicine
Session IV
Mon 8 p.m.- 9:30 p.m. | Neurotransmitter Transporters |
(Michael Kavanaugh, Discussion leader)
Norepinephrine Transporter Mutations in Cardiovascular Disorders-The First of Many?
Randy Blakely, Vanderbilt University
GTRAP: Interacting Protein Modulators of Glutamate Transporter Subtypes
Jeffrey Rothstein, Johns Hopkins University
Secondary and Tertiary Structure (and Primary Function) in Serotonin Transporter
Gary Rudnick, Yale University
Session V
Tues 9 a.m.- 12:30 p.m. | Transport structure/function
studies and novel overexpression systems |
(Nancy Carrasco, Discussion leader)
Directed Approaches to Membrane Protein Crystallography
Michael C. Wiener, University of Virginia
Overexpression of the Mitochondrial Transport Proteins
Ronald S. Kaplan, FUHS The Chicago Medical School
Cardiac Sodium-Calcium Exchange: A Novel, High Yield Expression System Leads to Growth of the First Mammalian Membrane Transporter Crystals
Calvin C. Hale, University of Missouri
Short presentations
Engineering conformational flexibility in the lac permease of E. Coli
Adam Weinglass, UCLA
Mutations in the anion exchanger 1 (AE1, Band 3): Structure, function and pathophysiology
Ashley Toye, University of Bristol
Session VI
Tues 8 p.m. - 9:30 p.m. | Structural modeling in Membrane Transport: Views from the Protein and the Substrate |
Molecular Modeling of Channels and Transporters
Robert Guy, NIH
Modeling and development of selective substrate and non-substrate inhibitors of
glutamate transporters
Richard Bridges, University of Montana
Session VII
Wed 9 a.m. - 12:30 p.m. | Membrane Transport Issues in Physiology and Pathophysiology |
(Matthias Hediger, Discussion leader)
The journey of the sodium/iodide symporter (NIS):
from obscurity to human evolution to medical practice
Nancy Carrasco, Albert Einstein College of Medicine
Nucleoside Transport in Parasitic Protozoans
Scott Landfear, Oregon Health Sciences University
Nucleoside transporters: regulators of Adenosine's receptor-mediated effects
Fiona Parkinson, University of Manitoba
Short presentations
Subcellular localization of the human nucleoside transporters hENT1 and hENT2 in mammalian cells
Miguel Cabrita, University of Alberta
A rat kidney-specific transporter that may participate in Ca++ reabsorption in the distal nephron
Ji-Bin Peng, Harvard University
Session VIII
Wed 8 p.m. - 9:30 p.m. | Amino Acid Transporters: Structure, Function, and Physiological Roles |
(Jeffrey Erickson, Discussion leader)
The Recycling of Glutamate
Robert Edwards, UCSF School of Medicine
Recent Advances in Neutral Amino Acid Transport
Jeffrey D. Erickson, LSUHSC
New Developments in Structure and Function of the EAAT/ASCT Family
Michael Kavanaugh, Vollum Institute
Session IX
Thur 9 a.m.- 12 p.m. | New Targets and Issues in Transport |
(Gary Rudnick, Discussion Leader)
Cloning and Characterization of High-Affinity Choline Transporters
Subbu Apparsundaram, University of Kentucky Medical Center
Amphetamine regulation of dopamine transport
Aurellio Galli, University of Texas HSCSA
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