SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Transporter conformational dynamics |
| Discussion Leader: Peter Henderson (University of Leeds, UK) |
7:35 pm - 8:00 pm | Baruch Kanner (Hebrew University Hadassah Medical School, Jerusalem)
"Two families of neurotransmitter transporters - different strategies to achieve the same goal" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Hassane Mchaourab (Vanderbilt University)
"Transporter dynamics studied by EPR spectroscopy" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Amy L. Davidson (Purdue University)
"The ABC maltose transporter: Alternating access mediated by rigid-body rotations" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Alexander D. Cameron (Imperial College, UK)
"Structure of Mhp1 in the inward facing conformation" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Transporter structure and mechanism |
| Discussion Leaders: Shimon Schuldiner (Hebrew University of Jerusalem) and Poul Nissen (University of Aarhus, Denmark) |
9:00 am - 9:25 am | Nico Reyes (Cornell University)
"Mechanism of glutamate transporters studied by X-ray crystallography" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Christine Ziegler (Max Planck Institute of Biophysics, Frankfurt am Main)
"Molecular basis of transport and regulation in the Na1/betaine symporter BetP" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Poul Nissen (University of Aarhus, Denmark)
"Structure and mechanisms of the calcium and sodium-potassium pumps" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Gary Rudnick (Yale University)
"Ion coupling in the neurotransmitter-sodium symporter family" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Da-Neng Wang (New York University School of Medicine)
"Structural basis of selectivity and gating mechanism of the organic-ion channel, FocA" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Lucy Forrest (Max Planck Institute of Biophysics, Frankfurt am Main)
"Symmetry and the art of transport: inverted-topology repeats reveal alternate conformations of neurotransmitter transporters" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Saba Abdul Hussein (MRC laboratory of molecular biology (lmb), Cambridge)
"Conformational thermostabilisation of the serotonin transporter" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Computational biology and high through put approaches in transporter research |
| Discussion Leaders: Harel Weinstein (Cornell University) and Jonathan Javitch (Columbia University) |
7:30 pm - 7:55 pm | Emad Tajkhorshid (University of Illinois at Urbana-Champaign)
"Computational approaches: transporters and channels" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Harel Weinstein (Cornell University)
"Dynamics of Neurotransmitter:Sodium Symporters determines function and changes the membrane environment" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Min Li (Johns Hopkins University)
"Chemical biology of ion channels and transporters" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Oliver Beckstein (University of Oxford, UK)
"Molecular simulations of ion-coupled transporters" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Iris Nasie (Hebrew University of Jerusalem)
"Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transporters" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transport proteins: pharmacology, physiology and disease |
| Discussion Leaders: Robert Tampe (Biocenter, Goethe-University, Frankfurt) and Randy Blakely (Vanderbilt University) |
9:00 am - 9:25 am | Robert Tampé (Biocenter, Goethe-University, Frankfurt)
"ABC transporters and immunity" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Marianne Wessling-Resnick (Harvard University)
"Iron transporter function and small molecule inhibitors" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Rajini Rao (Johns Hopkins University)
"Calcium signaling by the secretory pathway Ca2+-ATPase in mammary tumors" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Leon O. Murphy (Novartis Institutes for BioMedical Research, Cambridge, MA)
"Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Shushi Nagamori (Osaka University, Japan)
"CE-MS based metabolome analysis in knockout mice reveals real physiological substrates of an organic anion transporter" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Markus Seeger (University of Zürich, Switzerland)
"In vitro selection of binders against ABC transporters exemplified by LmrCD-specific DARPins" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transporter genetics and disease |
| Discussion Leader: Manuel Palacin (University of Barcelona) |
7:30 pm - 7:55 pm | Randy Blakely (Vanderbilt University)
"Change that Matters: Serotonin Transporter Genetic Variation and Autism Traits" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Michael Köttgen (University Hospital Freiburg)
"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Stefan Broer (Australian National University, Canberra)
From simple to complex - the genetics of renal aminoacidurias |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Michael R. Koelle (Yale University School of Medicine)
"Two types of chloride-extruding transporters are required for GABAA receptor-mediated inhibition in C. elegans" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Claudia Doberenz (University Halle, Germany)
"Characterisation of the Formate Channel Protein FocA of Escherichia coli" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Intracellular transporters and channels |
| Discussion Leader: Robert Edwards (UCSF) |
9:00 am - 9:25 am | Yoshinori Moriyama (Okayama University, Japan)
"Vesicular aspartate and nucleotide transporters" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Thomas J. Jentsch (Lebiniz-Institut für Molekulare Pharmakologie and Max-Delbrück-Centrum für Molekulare Medizin, Berlin)
"CLC Cl-/H+ exchangers in endosomes and lysosomes" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Joe Mindell (National Institute of Neurological Disorders and Stroke)
"The Cl-/H+ antiporter ClC-7 in lysosomes" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Shigeo Takamori (Doshisha University, Kyoto, Japan)
"A chloride conductance in the vesicular glutamate transporters" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Pascal Courville (Stanford University)
"The role of titratable residues in the function of sialin" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Thomas Hnasko (UCSF)
"Vesicular glutamate transport promotes monoamine storage through a mechanism distinct from chloride" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transporters and brain function in health and disease |
| Discussion Leader: Aurelio Galli (Vanderbilt University) |
7:30 pm - 7:55 pm | Kai Kaila (University of Helsinki)
"Cation-chloride cotransporters and neuronal function" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Jeff Rothstein (Johns Hopkins University)
"Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Harald Sitte (Medical University of Vienna)
"ER export, assembly and lipid regulation of monoamine transporters" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Lynette Daws (University of Texas Health Science Center at San Antonio)
"Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | Cellular regulation of transporters |
| Discussion Leader: Lydia Aguilar-Bryan (Pacific Northwest Research Institute) |
9:00 am - 9:25 am | Jonathan Javitch (Columbia University)
"Delineating molecular mechanisms of amphetamine action in Drosophila melanogaster" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Haoxing Xu (University of Michigan)
"Regulation of the type IV mucolipidosis-associated protein TRPML1 - an endolysosomal iron release channel" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:55 am | Amira Klip (Hospital for Sick Children, Toronto)
"Exocytic and endocytic regulation of GLUT4 traffic" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Bernard C. Rossier (University of Lausanne)
"Activation of the epithelial sodium channel (ENaC) by serine proteases" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Gonzalo E. Torres (University of Pittsburgh)
"Monoamine transporter protein-protein interactions" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Haley Melikian (University of Massachusetts Medical School)
"PKC-mediated dopamine transporter internalization requires the plasma membrane GTPase, Rin" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jan H. Reiling (Whitehead Institute for Biomedical Research)
"The putative transporter MFSD2A mediates tunicamycin-induced ER stress" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote presentation |
| Discussion Leader: Ulrik Gether (University of Copenhagen) |
7:30 pm - 8:30 pm | David Clapham (Harvard University)
"Mitochondrial calcium entry mechanisms" |
8:30 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |