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Membrane Transport Proteins

Gordon Research Conference

July 1 - 6, 2012
Chair Robert H. Edwards
Vice Chair Poul Nissen
Les Diablerets Conference Center
Eurotel Victoria
Les Diablerets, Vaud (fr), Switzerland
 Venue and Travel Information

Conference Description

The Gordon Research Conference on Membrane Transport Proteins, held for the 8th time in 2012, will address the physiological role of membrane transport from a range of system and experimental perspectives. Recent developments, particularly in the area of protein structure, have revealed unanticipated commonality among different transport systems, and this conference aims to bring together investigators working in fields from plant biology to neuroscience who might not otherwise interact. It will also focus on transport systems from pumps to ATP-binding cassette (ABC), secondary active ion-coupled transporters, organellar carriers and channels, and bring together groups with different experimental approaches from cell biology and genetics to biophysics and structure. The talks will focus on the relationship between mechanism and physiology, including disease. The program will include junior as well as senior investigators, and several posters will be selected for oral presentation. In addition, the programmed discussion time, afternoon free time and poster sessions as well as meals will provide abundant time for interaction among the diverse groups.

Conference Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNeurotransmitter Transporters
Discussion Leader: Jonathan Javitch (Columbia)
7:40 pm - 8:05 pmBaruch Kanner (Hebrew University)
"Mechanism of Sodium-Coupled Neurotransmitter Transport"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmUlrik Gether (Copenhagen)
"The dopamine transporter: PICK1'ing new functions of C-terminal binding partners"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmAurelio Galli (Vanderbilt)
"DAT N-terminus: levering transport function, lipid interactions and neuropsychiatric disorders"
9:15 pm - 9:25 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransporter Structure and Mechanism I
Discussion Leader: Poul Nissen (Aarhus)
9:00 am - 9:25 amRaimund Dutzler (Zurich)
"Activation and inhibition of prokaryotic pentameric ligand-gated ion channels"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDaniela Stock (Victor Chang Cardiac Research Institute, New South Wales)
"Structure and dynamics of rotary ATPases"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:30 am - 10:55 amDa-Neng Wang (NYU)
"Structure and mechanism of a bacterial nutrient transporter"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amMing Zhou (Baylor College of Medicine)
"Structure and function of potassium ion transporter TrkH"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amFilippo Mancia (Columbia)
"Crystal structure of sulfate transporter CysZ"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmSeok-Yong Lee (Duke)
"Structural basis of concentrative nucleoside transport"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pmSteffen Sinning (Aarhus)
"A trigger mechanism in the human serotonin transporter"
12:20 pm - 12:25 pm Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmPlant Transporters
Discussion Leader: Randy Blakely (Vanderbilt)
5:30 pm - 5:55 pmJiri Friml (Ghent)
"Auxin transport: Cellular regulation and developmental output"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:25 pmWolf Frommer (Carnegie/Stanford)
"SWEET sugar transporters in plants and humans"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmAngus Murphy (Purdue)
"Substrate conentration and sphingolipid regulation of plant ABCB transporter trafficking and activity"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmGreg Vert (Montpellier, Salk)
"Spatial and temporal control of root iron uptake in plants"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransporter Structure and Mechanism II
Discussion Leader: Robert Tampe (Biocenter, Goethe-University, Frankfurt)
9:00 am - 9:25 amKaspar Locher (ETH, Zurich)
"Transport mechanism of the bacterial cobalamin (vitamin B12) transporter BtuCDF revealed by multiple crystal structures"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDoug Rees (CalTech)
"Structural studies of ABC transporters"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:30 am - 10:55 amDirk Slotboom (Groningen)
"The structural basis of modularity in ECF-type ABC transporters"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amRobert Stroud (UCSF)
"Metal efflux transporters in metal ion-resistant organisms"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmChristine Ziegler (MPI, Frankfurt)
"Regulated transport in the bacterial betaine transporter BetP and its implications for eukaryotic osmolyte transporters"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmHartmut Luecke (UC Irvine)
"Crystal structure of a H+-gated urea channel from Helicobacter"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMitochondria
Discussion Leader: Baruch Kanner (Hebrew University)
5:30 pm - 5:55 pmJames Chou (Harvard)
"Using high resolution NMR to probe various conformational states of mitochondrial carriers linked to substrate transport"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:25 pmEdmund Kunji (Cambridge)
"The Transport Mechanism of Mitochondrial Transport Proteins"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmYuriy Kirichok (UCSF)
"How Brown Fat Makes Heat: Mechanism of Thermogenic Proton Leak Across the Inner Mitochondrial Membrane"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmChitra Shintre (Oxford)
"Structure and function of mitochondrial ABCB10"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmDonatella Giovannini (IGMM-CNRS)
"Inorganic phosphate export by XPR1"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Biology
Discussion Leader: Jeff Rothstein (Johns Hopkins)
9:00 am - 9:25 amSergio Grinstein (Toronto)
"Role of phospholipids and the cytoskeleton in membrane protein mobility and function"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amFrances Brodsky (UCSF)
"The Human Side of Glucose Transport"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:30 am - 10:55 amJohn Orlowski (McGill)
"Na+/H+ Exchange"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amRajini Rao (Johns Hopkins)
"Functional evaluation of autism-associated mutations in endosomal NHE9"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amAi Yamamoto (Columbia)
"Role of Raft Protein Flotillin-1 in DAT Function"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmBruno Andre (Brussels)
"Molecular dissection of substrate-induced transporter endocytosis"
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:20 pmLina Malinauskaite (Aarhus)
"Clues to neurotransmitter-sodium symporters from MhsT of B. halodurans"
12:20 pm - 12:25 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMetal Transport
Discussion Leader: Robert Edwards (UCSF)
5:30 pm - 5:55 pmDax Fu (Brookhaven)
"Structure and mechanism of zinc transporters"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:30 pmEdward Yu (Iowa)
"Structure and mechanism of the CusCBA heavy-metal efflux systems"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 6:50 pmTim Rasmussen (Aberdeen)
"Bacterial protection against electrophiles by K+ efflux system Kef"
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:05 pmYoshiki Tanaka (Tokyo)
"Structure of MATE multi-drug transporter"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmShigeo Takamori (Doshisha)
"Mechanism of vesicular glutamate transport"
7:20 pm - 7:25 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeuroscience
Discussion Leader: Yuriy Kirichok (UCSF)
9:00 am - 9:25 amRandy Blakely (Vanderbilt)
"Single molecule visualization of neurotransmitter transporter regulation"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJeff Rothstein (Johns Hopkins)
"Glutamate Transport"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:30 am - 10:55 amJonathan Javitch (Columbia)
"Amphetamine Action in Drosophila Melanogaster"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amDeborah Nelson (U Chicago)
"Multivariate approaches to the dynamic study of intracellular vesicle function"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmThomas Jentsch (Max Delbruck Center, Berlin)
"Analysis of the ClC Family In Vivo"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmDana Yaffe (Hebrew University)
"Mechanism of a novel hydrogen bond cluster in VMAT2"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session
Discussion Leader: Robert Edwards (UCSF)
5:30 pm - 5:45 pmTomohiro Nishizawa (Tokyo)
"Molecular mechanism of calcium exchange"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmMoshe Kafri (Weizmann)
"A systems analysis of phosphate transport in yeast"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 7:00 pmWilliam Catterall (University of Washington)
"Na+ channel biology and mechanism"
7:00 pm - 7:10 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

Conference Links

Conference History
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