| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Late-Breaking Topics in Membrane Transport Research |
| Discussion Leader: Poul Nissen (Aarhus University) |
| 7:40 pm - 8:05 pm | Ernst Bamberg (Max Planck Institute for Biophysics, Frankfurt)
"Channelrhodopsin: Molecular Mechanism and Optogenetics"
|
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:30 pm | William Kobertz (University of Massachussetts Medical School)
"Visualizing Cation Efflux from Living Cells"
|
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:50 pm | Rikard Blunck (University of Montreal)
"Cytosolic Activation Dynamics in the Kv Channel Probed by a Fluorescent Unnatural Amino Acid"
|
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Yifan Cheng (University of California San Francisco)
"The Structure of the TRPV1 Ion Channel Revealed by Single Particle Cryo-EM"
|
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Ion Exchangers in Health and Disease |
| Discussion Leader: Rajini Rao (Johns Hopkin University of Medicine) |
| 9:00 am - 9:25 am | Daniel Fuster (University of Bern)
"Physiological Role of the Sodium/Hydrogen Exchanger NHA2"
|
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Nanna Macaulay (University of Copenhagen)
"K+ Clearance in the Brain - Which Molecular Transport Mechanisms?"
|
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | David Drew (Stockholm University)
"A Two-Domain Elevator Mechanism for Sodium/Proton Antiport" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Özkan Yildiz (Max Planck Institute of Biophysics, Frankfurt)
"pH- and Sodium-Induced Changes in a Sodium/Proton Antiporter"
|
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 10:55 am - 11:20 am | Eric Morrow (Brown University)
"The Role of Endosomal Na+/H+ Exchangers in Autism and Related Disorders"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Jose Llongueras (Johns Hopkins University School of Medicine)
"Na+/H+ Exchanger NHE9 Drives Tumor Progression of Glioblastoma Multiforme by Altering Endosomal pH" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Martin Puskarjov (University of Helsinki)
"KCC2: A Neuron-Specific Multifunctional K-Cl Cotransporter"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Sodium and Potassium Transporters |
| Discussion Leader: Hanne Poulsen (Aarhus University) |
| 7:30 pm - 7:55 pm | David Goldstein (Duke University)
"Na,K-ATPase and Alternating Hemiplegia of Childhood"
|
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Karin Lykke-Hartmann (Aarhus University)
"Mouse Models of Na,K-ATPase Mutations in Neurological Diseases"
|
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:50 pm | Natascia Vedovato (University of Oxford)
"Mechanisms Of Na,K-ATPase Pump Dysfunction Caused by Mutations Underlying Alternating Hemiplegia of Childhood" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | Maki Kaneko (Scripps Research Institute)
"Effects of Disease-Aggravating Factors on Ionic Leakage Elicited by Dominant Mutations of Type II P-Type ATPases" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Poster Previews |
|
- Anna Bartsch (University of Cologne)
- Leann Buhrow (National Research Council Canada)
- Lora Deuitch (National Institute of Mental Health, NIMH)
- Charles Heilig (University of Florida College of Medicine-Jackson)
- Matthew Loewen (University of Saskatchewan, WCVM, VBMS)
- Heinrich Matthies (Vanderbilt University School of Medicine)
|
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Anion Transport Proteins |
| Discussion Leader: Lydia Aguilar-Bryan (Pacific Northwest Diabetes Research Institute, Seattle) |
| 9:00 am - 9:30 am | Criss Hartzell (Emory University School of Medicine, Atlanta)
"The Role of Ca-Activated Cl Channel Tmem16A/ANO1 in Development of the Primary Cilium"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:50 am | Anke Bill (Novartis Institutes for Biomedical Research)
"Functional Characterization of the Calcium-Activated Chloride Channel ANO1 and Its Role in Disease"
|
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:20 am | Thomas Jentsch (Leibnitz Institute and Max Delbrück Center, Berlin)
"Molecular Composition of the Volume-Stimulated Organic Osmolyte / Anion Channel VSOAC" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:25 am | Lydia Aguilar Bryan (Pacific Northwest Diabetes Research Institute)
"CFTR in Human Islets: Potential Implications for CFRD"
|
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 11:50 am | Cristina Fenollar-Ferrer (NIH/NINDS)
"Structural Model of the Human Sodium-Phosphate Cotransporter NaPi-II"
|
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Joseph Mindell (NIH, NINDS)
"Dynamic Feature of Secondary Active Transporters" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Transporters in Plants and Pathogens |
| Discussion Leader: Ming Zhou (Baylor College) |
| 7:30 pm - 7:50 pm | Kiaran Kirk (The Australian National University)
"Targeting an Ion Pump in the Malaria Parasite with New Generation Antimalarials"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Neils Quashie (University of Ghana)
"Purine Transport in Plasmodium falciparum-Infected Human Erythrocytes"
|
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Enrico Martinoia (University of Zürich)
"Plant ABC Transporters Play a Central Role in Phytohormone Transport"
|
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Jyh-Yeuan Lee (University of Texas Southwestern)
"Structure of Human Cholesterol Transporter ABCG5/ABCG8" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Elizabeth Ennis (Vanderbilt University, Tennessee)
"A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter"
|
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Avisek Das (University of Chicago)
"Simulation of Conformational Transition Pathways in the Calcium Pump"
|
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Heavy-Metal, Peptide and Lipid Transporters |
| Discussion Leader: Svetlana Lutsenko (Johns Hopkins University of Medicine) |
| 9:00 am - 9:25 am | Svetlana Lutsenko (Johns Hopkins University of Medicine)
"The Human Copper Transporters ATP7A and ATP7B" |
| 9:25 am - 9:35 am | Discussion
|
| 9:35 am - 9:50 am | Pontus Gourdon (University of Copenhagen)
"Structure and Function of Cu+ and Zn2+-ATPases"
|
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:15 am | Michael G. Palmgren (University of Copenhagen)
"The Transported Ligand of Orphan P5-ATPases"
|
| 10:15 am - 10:25 am | Discussion |
| 10:25 am | Coffee Break |
| 11:00 am - 11:20 am | Todd Graham (Vanderbilt University, Tennessee)
"Phospholipid Recognition and Flip by P4-ATPases"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Ines Ehrnstorfer (University of Zürich)
"The Structural Basis for Ion Selectivity in Transition Metal Ion Transporters of the SLC11/NRAMP Family"
|
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Qun Liu (Brookhaven National Laboratory)
"Crystal Structures of a pH Sensitive Calcium Leak Channel"
|
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Simon Newstead (University of Oxford)
"On the Origin of Promiscuity in the PTR Family of Proton Coupled Peptide Transporters" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Neurotransmitter Transporters |
| Discussion Leader: Baruch Kanner (Hebrew University of Jerusalem) |
| 7:30 pm - 7:50 pm | Baruch Kanner (Hebrew University of Jerusalem)
"Anion Conductance of the Glutamate Transporter"
|
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:10 pm | Nurunisa Akyuz (Weill-Cornell Medical College, New York)
"Structural Unlocking in a Glutamate Transporter Homologue"
|
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Robert Edwards (University of California San Francisco)
"The Regulation of Vesicular Glutamate Transport"
|
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Harald Sitte (Medical University of Vienna)
"Transporters in Motion: Combining Computational Approaches and LRET-Measurements" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Poster Previews |
|
- Julia Preobraschenski (Max Planck Institute for Biophysical Chemistry)
- Seth Robia (Loyola University Chicago)
- Albert Rosell (Institute for Research in Biomedicine)
- Huan Rui (The University of Chicago)
- Sanjaya Sahoo (The Ohio State University)
- Eliza Zielazinski (Argonne National Laboratory)
|
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Dopamine Transporters in Health and Disease |
| 9:00 am - 9:10 am | Discussion Leader: Ulrik Gether (University of Copenhagen)
"Introduction" |
| 9:10 am - 9:35 am | Jonathan Javitch (Columbia University)
"It Takes Two: Amphetamine Requires Tandem DAT and VMAT Function for Its In Vivo Actions"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Eric Gouaux (Vollum Institute, Oregon Health & Science University)
"Structure, Mechanism and Inhibition of the Dopamine Transporter"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:40 am - 10:55 am | Lina Malinauskaite (Aarhus University)
"New Insights into the Transport Mechanism of the NSS Family" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:15 am | Gary Rudnick (Yale University)
"How Na+ Affects Conformational Change in LeuT"
|
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 11:35 am | Birgit Schiøtt (Aarhus University)
"Conformational Dynamics of NSS Transporters from MD Simulations"
|
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 11:50 am | Peter Hamilton (Vanderbilt University, Tennessee)
"Dopamine Transporter Mutations and Autism Spectrum Disorder"
|
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Lucia Carvelli (University of North Dakota)
"Amphetamine Decreases the Expression of the Dopamine Transporter: An In Vivo Study"
|
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Claus Løland (University of Copenhagen)
"Probing Conformational Changes in a Neurotransmitter: Sodium Symporter with Transition Metal FRET"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: New Methods in Membrane Transport Research |
| Discussion Leader: Michael G. Palmgren (University of Copenhagen) |
| 7:30 pm - 8:10 pm | Edward Boyden (Massachussetts Institute of Technology)
"Optogenetics: Membrane Transport Proteins as Tools for Mapping the Brain"
|
| 8:10 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:50 pm | Dirk Trauner (University of Munich)
"The Photopharmacology of Transmembrane Proteins"
|
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Sonia Antoranz Contera (University of Oxford)
"AFM Can Link Structure, Mechanics and Cooperativity of Membrane Proteins"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
