Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Molecules in Motion: Transporter Dynamics, Single Molecules and Movies |
| Speakers in this session use cutting edge approaches to map out
conformational changes in elegant molecular detail. |
| Discussion Leader: Nieng Yan (Tsinghua University, China) |
7:40 pm - 8:00 pm | Lucy Forrest (National Institute of Neurological Disorders and Stroke, NIH, USA) "Secondary Transport: Does Taking the Elevator Rock the Boat?" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Hassane Mchaourab (Vanderbilt University, USA) "Ion Coupling and Alternating Access of LeuT-Fold Transporters" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Emad Tajkhorshid (University of Illinois at Urbana-Champaign, USA) "Atomic-Level Characterization of Structural Transitions and Energy Landscapes in Membrane Transporters" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Mateusz Dyla (Aarhus University, Denmark) "Structure and Dynamics of an Ion Pump at the Single-Molecule Level" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Big Data: Virtual Mining, Genomes and Phenomes |
| Innovative approaches to effectively mine and
harness genomic, chemical and patient data. |
| Discussion Leader: Aurelio Galli (Vanderbilt University, USA) |
9:00 am - 9:25 am | Ramanath Hegde (Institute of Protein Biochemistry, National Research Council, Italy) "Druggable F508del-CFTR Proteostasis Regulatory Network Identified by Meta-Analysis of Corrector Gene Expression Signatures" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Giulio Superti-Furga (Center for Molecular Medicine, Austrian Academy of Sciences, Austria) "Solute Carriers, Metabolism and Drug Response: A Magic Triangle" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Gerda Breitwieser (Weis Center for Research, Geisinger Health System, USA) "Using PheWAS and SKAT-O to Define Disease Associations in Large Datasets of Human Gene Variants" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Jean-Louis Reymond (University of Bern, Switzerland) "Chemical Space Driven Discovery of Transporter Inhibitors" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Hari Prasad (Johns Hopkins University School of Medicine, USA) "Mining
Patient Databases for Testable Hypotheses in Neurodegenerative Disorders" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Jose Llongueras (Johns Hopkins University School of Medicine, USA) "Cancer
Genome Databases Reveal New Pathways in Tumorigenesis" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Thomas Hopf (Harvard Medical School, USA) "Using Evolutionary Information to Predict Transporter Specificity and Conformational Flexibility" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Christiane Albrecht (University of Bern, Switzerland) |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | TRP Channels in Health and Disease |
| This session will cover ion channels in taste perception, cancer and other channelopathies. |
| Discussion Leader: Joseph Bryan (Pacific Northwest Diabetes Research Institute, USA) |
6:00 pm - 6:25 pm | Emily Liman (University of Southern California, USA) "Sensing Acids Through TRP Channel-Dependent and Independent Mechanisms in Sensory Neurons" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:55 pm | Haoxing Xu (University of Michigan, USA) "Lysosomal Physiology and Calcium Signaling" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | Dimitra Gkika (INSERM, France) "TRPM8 Channel Puts the Chill on Prostate Cancer Cell Migration" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:55 pm | Christine Ziegler (University of Regensburg, Germany) "Polycystin-2: The Mysterious Role of a TRP Channel in ER Calcium-Signaling" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Unconventional Transporters: Flipping Lipids, Porting Peptides and More |
| Clinically important transporters, including ABC pumps, that bridge the mechanistic divide between channels and transporters. |
| Discussion Leader: Simon Newstead (University of Oxford, United Kingdom) |
9:00 am - 9:25 am | Raimund Dutzler (University of Zurich, Switzerland) "Ion and Lipid Transport by TMEM16 Family of Calcium Activated Channels and Scramblases" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Luis Galietta (Istituto Giannina Gaslini, Italy) "Anoctamins: Channels or Scramblases?" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Christiane Albrecht (University of Bern, Switzerland) "Placental Membrane Transporters: Bottleneck Between Mother and Fetus?" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Jyh-Yeuan (Eric) Lee (University of Texas Southwestern Medical Center, USA) "ABCG5/ABCG8: A Structural View on Sterol Transport" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Robert Tampe (Goethe-University Frankfurt, Germany) "Lipid and Peptides on the Move: New Twists and Turns on ABC Transporters" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Katharina Jungnickel (University of Oxford, United Kingdom) "Structural and Functional Studies on a Proton-Coupled Amino Acid Transporter" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Toshihiko Kobayashi (National Center for Global Health and Medicine, Japan) "Oligopeptide Transporter SLC15A4 Regulates Allergic Reactions by Controlling Mast Cell Homeostasis and Inflammatory Response" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Transport in 3D: From Stem Cells to Organoids |
| Replacing traditional cell culture with stem cells and 3D approaches that capture complex spatial interactions in tissues. |
| Discussion Leader: Kathy Sweadner (Massachusetts General Hospital / Harvard Medical School, USA) |
6:00 pm - 6:25 pm | Sofia Lizarraga (University of South Carolina, USA) "The Role of NHE6 in Christianson Syndrome Neuronal Pathology: A Stem Cell Model" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:55 pm | Stine Pedersen (University of Copenhagen, Denmark) "3D Multicellular Models to Study the Regulation and Roles of Acid-Base Transporters in Breast Cancer" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | Mark Donowitz (Johns Hopkins University School of Medicine, USA) "Human Enteroids as a Model for Human Intestinal Transport Physiology and Host Pathogen Interactions" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:55 pm | Daniela Rotin (Hospital for Sick Children, Canada) "Analysis of the Regulation of ENaC and NKCC1 by Nedd4-2 Using Tissue Organoids and Knockout Mice" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neurochemistry and Neurotransmitter Transporters |
| This session covers transporters in neurological disorders and as targets of psychostimulants and antidepressants. |
| Discussion Leader: Harald Sitte (Medical University of Vienna, Austria) |
9:00 am - 9:25 am | Gaia Novarino (IST Austria, Austria) "Abnormal Amino Acid Transport Across the Blood Brain Barrier Leads to Neurodevelopment Defects and Autism Spectrum Disorder" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Jonathan Coleman (Oregon Health and Science University, USA) "X-Ray Structures of Serotonin Transporter Define Mechanisms of Inhibition and Allosteric Modulation" |
9:40 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Thomas Stockner (Medical University of Vienna, Austria) "Development of a Zinc-Dependent Serotonin Transporter by a Combined Experimental and Computational Approach" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Nicolas Reyes (Pasteur Institute, France) "Structural Studies of an Excitatory Amino Acid Transporter" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Thomas Steinkellner (University of California, San Diego, USA) "Selective Vulnerability of Dopamine Neurons to Excitotoxic Stress: A New Model of Parkinson's Disease" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Ulrik Gether (University of Copenhagen, Denmark) "The Dopamine Transporter: A Key Player in Psychostimulant Addiction and Dopaminergic Pathologies" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Manju Kurian (School of Life and Medical Sciences, University College London, United Kingdom) "Dopamine Transporter Deficiency Syndrome: Phenotype, Genotype and Novel Therapeutic Strategies" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Aurelio Galli (Vanderbilt University, USA) "Failure to Prime the Dopamine 'Pump' in Autism" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Bench to Bedside: Perspectives from Pharma |
| Leaders from industry address challenges and successes in translating basic science research into clinical advances that impact disease. |
| Discussion Leader: Paul Wren (GlaxoSmithKline, United Kingdom) |
6:00 pm - 6:15 pm | Introduction by Discussion Leader |
6:15 pm - 6:40 pm | Claire Steppan (Pfizer Corporation, USA) "Solute Carriers (SLCs) as Drug Targets: Challenges and Opportunities" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Jeremy Caldwell (Ardelyx, Inc., USA) "Tenapanor - Harnessing GI Physiology with a Minimally Systemic, Gut Targeted NHE3 Inhibitor to Address Unmet Medical Need" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:40 pm | Adam Weinglass (Merck & Co., USA) "ROMK and NPC1L1 - Basic Science to Clinic and Back" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Thomas Licher (Sanofi, Germany) "Approaches and Workflows for Transporter Projects with a Special Focus on SURFE(2)R Technology" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Transporter Trafficking, Pharmaco-Chaperones and Vesicular Transport |
| Biogenesis, folding and delivery of transporters, endo-lysosomal transport, small molecule correctors and diseases. |
| Discussion Leader: Lydia Aguilar-Bryan (Pacific Northwest Diabetes Research Institute, USA) |
9:00 am - 9:25 am | Michael Freissmuth (Medical University of Vienna, Austria) "Sleepless in Vienna: How to Rescue Misfolded SERT and DAT" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Mondira Kundu (St. Jude Children's Research Hospital, USA) "The Autophagy-Inducing Kinase ULK/ATG1 Regulates ER-to-Golgi Trafficking of SERT" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Haley Melikian (University of Massachusetts Medical School, USA) "Controlling Dopamine Transporter Membrane Stability: Trafficking, Braking and Potential for ADHD Rescue" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Margarida Amaral (BioISI - Biosystems and Integrative Sciences Institute, University of Lisboa, Portugal) "CFTR: Translating Science into Treatment" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:30 am | Liudmila Cebotaru (Johns Hopkins University, USA) "Rescuing ABCA4 Trafficking Mutants in Stargardt Disease" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Joseph Mindell (National Institute of Neurological Disorders and Stroke, NIH, USA) "Role of Chloride Transport in Lysosomal pH Regulation" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Robert Edwards (University of California, San Francisco, USA) "The Regulation of Glutamate Release by Protons" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Keynote Session: Structural Insight into Disease |
| The keynote session will link transporter structure and gene variants to human disease. |
| Discussion Leader: Rajini Rao (Johns Hopkins University School of Medicine, USA) |
6:00 pm - 6:25 pm | Joseph Bryan (Pacific Northwest Diabetes Research Institute, USA) "The Flip Side: What Disease Tells Us About an Ion Channel" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:55 pm | Kathy Sweadner (Massachusetts General Hospital / Harvard Medical School, USA) "Mutations and Phenotypes in Na, K-ATPase Diseases" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:25 pm | Dax Fu (Johns Hopkins University, USA) "Human Zinc Transporter ZnT8: Bridging Between Genetic Discoveries and Drug Development" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:55 pm | Alexander M. Cruickshank Lecture: Nieng Yan (Tsinghua University, China) "Crossing the Boundary: Towards a Molecular Understanding of Solute Transport" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |