Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Brain Matters: Membrane Transporters in Glia and Their Relationship to Disease
Discussion Leader: Jeffrey Rothstein (Johns Hopkins University, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Renae Ryan (University of Sydney, Australia)
"The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Michael Robinson (Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"Astrocytic Glutamate Transport, Mitochondria, and Calcium: What's a Little Energy Among Friends?"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Rebecca Seal (University of Pittsburgh, USA)
"VGLUT3 in Parkinson's Disease"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Rajini Rao (Johns Hopkins University, USA)
"Endosomal pH as Therapeutic Target for Neurological Disorders"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Insights into Transporter Function: State-of-the Art Approaches
Discussion Leader: Ulrik Gether (University of Copenhagen, Denmark)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Claus Loland (University of Copenhagen, Denmark)
"Monitoring Conformational Dynamics upon Ligand Binding in Neurotransmitter:Sodium Symporters"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Peter Hinterdorfer (Johannes Kepler University Linz, Austria)
"Nanopharmacological Force Sensing Reveals Two Ligand Binding Sites in Monoamine Transporters"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Thorben Cordes (LMU Biocenter, Ludwig Maximilian University of Munich, Germany)
"Single-Molecule Approaches to Monitor Conformational Dynamics in ABC Transporters"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
Dimitrios Stamou (University of Copenhagen, Denmark)
"Single Molecule Measurements Catch Transporters 'Taking a Break': On the Crucial Importance of Off-Cycle States for Function and Regulation"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Avner Schlessinger (Icahn School of Medicine at Mount Sinai, USA)
"Computer-Aided Drug Design Targeting Human Solute Carrier Transporters"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Patrick Kearney (University of Massachusetts Medical School, USA)
"Presynaptic Gq-Coupled Receptor Activation Drives D2-Dependent, Biphasic Dopamine Transporter Surface Trafficking"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Oleg Kovtun (Vanderbilt University, USA)
"Quantum Dots Reveal Differential Membrane Compartmentalization of Dopamine Transporter and Dopamine D2 Autoreceptor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Imogen Coe (Ryerson University, Canada)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Trafficking: Chaperoning Services
Discussion Leader: Michael Freissmuth (Medical University of Vienna, Austria)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Habibeh Khoshbouei (University of Florida, USA)
"Differential Regulation of Dopamine Transporter Activity in the SN and VTA"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Imogen Coe (Ryerson University, Canada)
"Nucleoside Transporters: New Modalities of Regulation and Therapeutics"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Nancy Leidenheimer (LSU Health Sciences Center Shreveport, USA)
"Cognate Ligand Chaperoning: A Novel Proteostatic Mechanism?"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Sabine Hadida (Vertex Pharmaceuticals, USA)
"Discovery of CFTR Modulators for the Treatment of Cystic Fibrosis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Plasma Membrane as a Regulator of Transport
Discussion Leader: Aurelio Galli (The University of Alabama at Birmingham, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Gerhard Schütz (TU Wien, Austria)
"How Lipids Shape Proteins Oligomers: A Case Study Using Single Molecule Microscopy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sharona Gordon (University of Washington, USA)
"Reciprocal Regulation Between TRPV1 and PI3K: Role in Inflammatory Sensitization"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Karen Fleming (Johns Hopkins University, USA)
"Energetics of Protein-Lipid Interactions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ai Yamamoto (Columbia University, USA)
"The Membrane Environment of DAT Plays a Critical Role in Promoting AMPH-Induced Efflux of DA Through DAT"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jenny Aguilar (Vanderbilt University, USA)
"Phosphatidylinositol (4, 5)-Bisphosphate Coordinates Functional Interactions in the Dopamine Transporter to Promote Amphetamine Behaviors"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Gabriella DiCarlo (Vanderbilt University, USA)
"Evidence for Dopamine Transporter Dysfunction in Autism Spectrum Disorder"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Marco Niello (Medical University of Vienna, Austria)
"Para-Substituted Methcathinones as Selective and Unselective Inhibitors of Human Dopamine and Serotonin Transporter"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Eric Geertsma (Goethe University Frankfurt, Germany)
"Structural Basis for Cooperativity in Dimeric SLC26 Transporters"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex as a Biological Variable in Transport Processes
Discussion Leader: Jana Haase (University College Dublin, Ireland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Theresa Powell (University of Colorado, USA)
"Membrane Transporter Function in the Human Placenta and Their Role in Pregnancy Complications and Life Long Health"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Erin Calipari (Vanderbilt University School of Medicine, USA)
"Estrous Cycle-Dependent Alterations in Stimulant Actions at the Dopamine Transporter Underlie Enhanced Cocaine Reward in Females"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Sandra Hewett (Syracuse University, USA)
"Sex Differences in Redox Environment and Neuronal Morphology Occur in Association with Enhancement of Excitability in System xc-Null Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Carolyn Ecelbarger (Georgetown University, USA)
"Sex Differences in Renal Transport Processes Regulated by Insulin and/or Insulin-Like-Growth Factors"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transporters in the Brain and Their Role in Disease
Discussion Leader: Haley Melikian (University of Massachusetts Medical School, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Susan Ingram (Oregon Health & Science University, USA)
"Dissecting the Many Roles of the Dopamine Transporter in the Regulation of Psychostimulant Addiction"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Gonzalo Torres (University of Florida College of Medicine, USA)
"G Protein Modulation of the Dopamine Transporter and the Actions of Amphetamine"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Randy Blakely (Florida Atlantic University, USA)
"Modeling Heritable Human Dopamine Transporter Dysfunction"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Steven Kushner (Erasmus University Medical Center, The Netherlands)
"Defective Zinc Transport as an Etiology of Autism"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Nanna MacAulay (University of Copenhagen, Denmark)
"Cerebro Spinal Fluid Production: We Know So Much and Understand So Little; Cotransporters as the Missing Link?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Louis-Eric Trudeau (University of Montreal, Canada)
"Striatal Neurons Regulate VGLUT2 Expression and Topography in Dopamine Neurons"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Julia Preobraschenski (Max Planck Institute for Biophysical Chemistry, Germany)
"Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transporters in Disease: CFTR and ABC-Transporters
Discussion Leader: David Hepworth (Pfizer, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Ina Urbatsch (Texas Tech University Health Sciences Center, USA)
"Interactions and Cooperativity Between P-Glycoprotein Structural Domains Determined by Thermal Uncoupling and LRET"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Show-Ling Shyng (Oregon Health and Science University, USA)
"Structural Mechanisms of KATP Channelopathies"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Simon Scheuring (Weill Cornell Medicine, USA)
"High-Speed Atomic Force Microscopy: Dynamics of Single Membrane Transporters and Channels in Membrane and Without Labels"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Patrick Thibodeau (University of Pittsburgh School of Medicine, USA)
"Biosynthetic Alterations and Correction in ABCC Proteins: Lessons Learned form CFTR and ABCC6"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Diabetes and Beyond: Transporters Are Key
Discussion Leader: Lydia Aguilar-Bryan (Pacific Northwest Diabetes Research Institute, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Michael Czech (University of Massachusetts Medical School, USA)
"Glucose Transport and Metabolism in Obesity and Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Timothy Ryan (Weill Cornell Medicine, USA)
"Hidden Metabolic Costs of Synaptic Transporters: Staying Ready for Action Is Expensive"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Mauricio DiFulvio (Wright State University, USA)
"Chloride Transporters in B-Cell Physiology"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
Damaris Lorenzo (University of North Carolina at Chapel Hill, USA)
"Regulation of GLUT4 Dynamics by Ankyrins: Implications for Metabolic Flux and Diabetes"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Eitan Hoch (Broad Institute of MIT and Harvard, USA)
"Needle in a Haystack: Threading the Link Between SLC16A11 and Type 2 Diabetes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Veronica Cochrane (Oregon Health & Science University, USA)
"Leptin Signals via a Novel Mechanism to Activate PKA for KATP Channel Trafficking to Suppress Insulin Secretion from Pancreatic B-Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Jacob Keller (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Sweet Oscillations: Transporter Measurements In Vitro and In Vivo Using a Novel Genetically-Encoded Biosensor for Glucose"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Transporters and Channels
Discussion Leader: Harald Sitte (Medical University of Vienna, Austria)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 6:05 pm
Kathleen Giacomini (University of California, San Francisco, USA)
"Genomewide and Evolutionary Studies Reveal Transporters as Determinants of Metabolic Disorders"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Sonja Sucic (Medical University of Vienna, Austria)
"4-Phenylbutyrate Corrects Folding-Deficient Creatine Transporter-1 Variants Associated with the Creatine Deficiency Syndrome"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Dongxue Yang (Oregon Health & Science University, USA)
"Structural Basis for Ibogaine Inhibition of hSERT Revealed by Single Particle Cryo-EM"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:15 pm
Francisco Bezanilla (University of Chicago, USA)
"Voltage Sensors and Membrane Capacitance"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure