Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Channelopathies and Transportopathies
Discussion Leader: Renae Ryan (University of Sydney, Australia)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Al George (Northwestern University, United States)
"Decrypting Variants of Unknown Significance in the Channelopathies Using Automated Patch Clamp"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Hanne Poulsen (Aarhus University, Denmark)
"Ins and Outs of the Na, K-ATPase"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Jeffrey Rothstein (Johns Hopkins University, United States)
"Disassembly and Assembly of Nuclear Pore Complex and Nuclear Transport in Neurodegeneration"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Michael Grabe (University of California, San Francisco, United States)
"Heating Things Up: a Mitochondrial Transporter that Thinks it’s a Channel"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeting Transporters for Pharmacotherapies
Discussion Leader: Renae Ryan (University of Sydney, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 10:05 am
Nancy Carrasco (Vanderbilt University, United States)
"The Sodium/Iodide Symporter (NIS): An Unending Source of Surprises"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Amy Newman (National Institute on Drug Abuse Intramural Research Program, NIH, United States)
"Novel and Atypical DAT Inhibitors for the Treatment of Psychostimulant Use Disorders"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Manuel Palacin (Institute for Research in Biomedicine, Spain)
"Mechanisms of Transport of LAT Transporters"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Robert Vandenberg (University of Sydney, Australia)
"Mechanism of Bioactive Lipid Inhibition of Glycine Transporters"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Suzanne Underhill (National Institute of Mental Health, NIH, United States)
"Regulation of a Neuronal Glutamate Transporter by Methamphetamine"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Renae Ryan (University of Sydney, Australia)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transporter Function and Dysfunction in Metabolism, Diabetes and Obesity
Discussion Leader: Habibeh Khoshbouei (University of Florida, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Zachary Freyberg (University of Pittsburgh, United States)
"Novel Roles for VGLUT2 in Health and Disease: From Flies to Humans"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Sophie Hambleton (Newcastle University, United Kingdom)
"Breaking the ZIP Code - a New Player in B Cell Development"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Amira Klip (The Hospital for Sick Children, Canada)
"Glucose Uptake Mechanisms in Muscle and the Endothelial Barrier"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Michael Köttgen (University Freiburg - Medical Center, Germany)
"The Mitochondrial Transporter SLC25A25 Links Ciliary TRPP2 Signaling and Cellular Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Invertebrates as Animal Models to Study Transporter Functions
Discussion Leaders: Randy Blakely (Florida Atlantic University, United States) and Freja Herborg (University of Copenhagen, Denmark)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 10:05 am
Susan Amara (National Institute of Mental Health, United States)
"Close Encounters: the Intimate Regulatory Relationships Between GPCR Signaling and Neurotransmitter Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Laura Bianchi (University of Miami, United States)
"Role of Glial Enriched Ion Channels and Transporters in C. Elegans Sensory Behaviors"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Lucia Carvelli (Florida Atlantic University, United States)
"Remembering the Past to Prepare for the Future: the Long-Term and Inherited Effects of Amphetamine at the Monoamine Transporters"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
David Krantz (University of California, Los Angeles, United States)
"New Drosophila Neuromodulatory Circuits to Probe Neurotransmitter Transporter Activity"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Samuel Mabry (University of Alabama at Birmingham, United States)
"Syntaxin1 Ser14 Phosphorylation is Required for Non-Vesicular Dopamine Release"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Na, K-ATPase and Related Pumps
Discussion Leader: Susan Ingram (Oregon Health & Science University, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Jonathan Javitch (Columbia University / New York State Psychiatric Institute, United States)
"Quantifying Secondary Transporter Activity at Single-Molecule Resolution"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Poul Nissen (Aarhus University, Denmark)
"Na, K-ATPase Brain Isoforms, AHC Neurological Disease Mutant"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Gergely Gyimesi (University of Bern, Switzerland)
"Fundamentals and Importance of the SLC Solute Carrier Superfamily: the New SLC Atlas"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Rajini Rao (Johns Hopkins University, United States)
"Late-Breaking Topic"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neurological and Neuropsychiatric Disorders: Transporters at Play
Discussion Leader: Rajini Rao (Johns Hopkins University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Haley Melikian (University of Massachusetts Medical School, United States)
"Regulated Dopamine Transporter Trafficking: Novel Mechanisms and Physiological Impact"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Claus Loland (University of Copenhagen, Denmark)
"The Dopamine Transporter Antiports Potassium to Increase the Uptake of Dopamine"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Ulrik Gether (University of Copenhagen, Denmark)
"Behavioral Encoding Across Timescales by Region-Specific Dopamine Dynamics: Is it all about DAT?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Harald Sitte (Medical University of Vienna, Austria)
"Novel Psychoactive Substances: Exploiting Rogue Chemicals as Therapeutic Scaffolds"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Cornelius Gati (University of Southern California, United States)
"Structural Basis of GABA Reuptake Inhibition"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Anna Campana (University of Copenhagen, Denmark)
"Systematic Characterization of Human Dopamine Transporter Missense Mutations from a Danish Cohort of Psychiatric Patients"
12:05 pm - 12:10 pm
Discussion
12:20 pm - 12:40 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Strategies, Ideas and Techniques to Study Membrane Protein Structure-Function and Trafficking
Discussion Leader: Ulrik Gether (University of Copenhagen, Denmark)
6:00 pm - 6:20 pm
Olga Boudker (Weill Cornell Medicine, United States)
"Membrane Responce to Domain Movements in a Glutamate Transporter Homologue"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Sergio Grinstein (The Hospital for Sick Children, Canada)
"Lipid-gated Monovalent Ion Fluxes in the Control of Endocytic Traffic"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Parastoo Hashemi (Imperial College London, United Kingdom)
"Histamine Transport: a Novel Antidepressant Strategy"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Robert Tampé (Goethe University Frankfurt, Germany)
"Catch Me If You Can: Transport and Chaperone Machineries in Adaptive Immunity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Peptides, Hormones, and Neurotransmitter Release: The Importance of Transporters in the Gut and Brain
Discussion Leaders: Michael Freissmuth (Medical University of Vienna, Austria)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Robert Edwards (University of California, San Francisco, United States)
"Integration of Vesicular Glutamate Transport into the Synaptic Vesicle Cycle"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Naoki Yamanaka (University of California, Riverside, United States)
"Neuroendocrine Functions of Steroid Hormone Transporters - Lessons from Fruit Fly Research"
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Giulio Superti-Furga (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences GmbH, Austria)
"Decoding the SLC Supergroup by Large-Scale Assessments and Deep Learning"
10:50 am - 10:55 am
Discussion
10:55 am - 11:15 am
Angela Carter (University of Alabama at Birmingham, United States)
"Mechanism for Microbial Regulation of Psychostimulant Abuse"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Mark Bolding (University of Alabama at Birmingham, United States)
"dTRPA1 May be a Candidate Receptor for a Novel Optogenetic Method Based on X-rays Instead of Visible Light"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Long Nguyen (National University of Singapore, Singapore)
"Critical Roles of Sphingosine-1-Phosphate Transporters for the Vasculature"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Detailing Mechanisms of Importers and Exporters
Discussion Leader: Elena Bossi (University of Insubria, Italy)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Isabelle Baconguis (Oregon Health and Science University, United States)
"Structure-Function Studies of ENaC"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Gracia Merino (University of Leon Q2432001B, Spain)
"Inhibition of the ABCG2 Membrane Transporter by Pesticides"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Alexandra Schwartz (Vanderbilt University, United States)
"Conformational Dynamics of a Neurotransmitter: Sodium Symporter Homolog"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Josep Font Sadurni (AbCellera, Australia)
"Late-Breaking Topic"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure