Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: High-Speed Atomic Force Microscopy: A Revolutionary New Technique to Study Membrane Proteins
Discussion Leader: Jose Pino (University of Florida, USA)
3:45 pm - 4:20 pm
Simon Scheuring (Weill Cornell Medicine, USA)
"High-Speed Atomic Force Microscopy: Taking Movies of Single Membrane Proteins at Work! ...and How I Got There"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Transport Proteins: Structure and Function
Discussion Leader: Aiping Zheng (University of Pittsburgh, USA)
7:30 pm - 7:45 pm
Rachel North (University of Canterbury, New Zealand)
"Substrate Ambiguity for the Sodium Sialic Acid Symporter from Staphylococcus aureus "
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Narakorn Khunweeraphong (Medical University of Vienna, Austria)
"Structure-Function of Human ABCG2: Evidence for a Novel Drug Transport Mechanism"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jonas Mortensen (University of Copenhagen, Denmark)
"A Conserved Tryptophan Regulates the Conformational Equilibrium in Neurotransmitter:Sodium Symporters"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Corinne Portioli (Baylor College of Medicine, USA)
"Characterization of the Structure-Function Relationship of the Na-K-Cl Importer NKCC1"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Anne Kathrine Nielsen (University of Copenhagen, Denmark)
"Ion- and Dopamine-Induced Conformational Dynamics of the Dopamine Transporter"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Brian DeVree (University of Copenhagen, Denmark)
"Overexpression and Purification of Human Dopamine Transporter"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Translational Membrane Protein Biology
Discussion Leader: Eric Figueroa (Vanderbilt University, USA)
9:00 am - 9:15 am
Felix Mayer (Institute of Pharmacology, Medical University of Vienna, Austria)
"Phase-1 Metabolites of Mephedrone Reveal Chiral Selectivity Towards the Serotonin Transporter"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Anna Vlachodimou (Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands)
"Label-Free Detection of Transporter Inhibitors' Efficacy in Living Cells"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Susanna Concilio (Mayo Clinic Graduate School of Biomedical Sciences, USA)
"Making a Better Sodium/Iodide Symporter: Unraveling the Mysteries of NIS Substrate Affinity and Promiscuity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Koketso Mogwera (Stellenbosch University, South Africa)
"Implications of Phosphopantetheine (P-PantSH) Membrane Transport in CoA Targeted Drug Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Vivek Mahadevan (National Institutes of Health, USA)
"Interaction Proteomics of Native KCC2 Reveal Key Components of Excitation-Inhibition Balance in the Central Nervous System (CNS)"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Conor McVeigh (University College Dublin, Ireland)
"Sex Differences in Chronic Inflammatory Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Young Scientist Career Paths
Representatives from academia, industry and scientific publishing will give an overview of their professional journeys and the current landscape for young scientists inside and outside the classical academic setting.
Discussion Leader: Vikas Navratna (Oregon Health and Science University, USA)
1:30 pm - 1:45 pm
David Hepworth (Pfizer, USA)
"From Making Toxins, to Avoiding Them: A Journey Towards Drug Discovery"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Gabriel Gasque (PLOS Biology, USA)
"Taking Ownership: Build the Mentorship You Need for Your Career to Succeed"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Freja Herborg (University of Copenhagen, Denmark)
"Navigating a Postdoc: When You Stop Trying to Figure It All Out"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
