| Sunday, January 24 |
| 4:00 pm |
Poster Session |
| 6:00 pm |
Dinner |
| Evening |
Metalloproteins: Evolutionary Aspects |
| 7:30-7:45 pm |
Introduction
Eckard Münck (Carnegie Mellon U.), Chair & Carlyle Storm (GRC) |
| 7:45-8:45 pm |
"Metalloprotein Families, Some Evolutionary Aspects"
Helmut Beinert, University of Wisconsin |
| 9:00 pm |
Chair's Reception/Poster Session I (A-I) |
| Monday, January 25 |
| 8:30 am |
Conference Photograph |
| Morning |
Photosystem II |
| 8:45-9:00 am |
Introduction
Bruce A. Diner, DuPont, Chair |
| 9:00-9:30 am |
"Modelling Photosynthetic Water Oxidation Chemistry"
Vincent L. Pecoraro, University of Michigan |
| 9:45-10:15 am |
"From Water to Oxygen and Back Again: Mechanistic Similarities between PSII and Cytochrome Oxidase"
Gerald T. Babcock, Michigan State University |
| 10:30-11:00 am |
Break |
| 11:00-11:30 am |
"EPR and EXAFS Studies of PSII"
Vittal Yachandra, Lawrence Berkeley National Laboratory |
| 11:45 am-12:15 pm |
"Pulsed and CW EPR Characterization of the Mn Cluster and the Tyrosine Yz Radical of the Photosynthetic Oxygen Evolving Complex"
Jeffrey M. Peloquin, University of California at Davis |
| Evening |
Ribozymes |
| 7:30-7:45 pm |
"Texaphyrin-based Nucleases: An Artificial Approach to Ribozyme Activity"
Darren Magda, Pharmacyclics, Chair of Session |
| 7:50-8:20 pm |
"Crystal Structure of a Hepatitis Delta Virus Ribozyme: Clues to the Catalytic Mechanism"
Jennifer Doudna, Yale University |
| 8:35-9:05 pm |
"Divalent Metal Ions in Catalysis of Phosphoryl Transfer by RNA and Protein Enzymes"
Daniel Herschlag, Stanford University |
| 9:20-9:35 pm |
"Spectroscopic Probes of Metal Interactions with the Hammerhead Ribozyme"
Victoria deRose, Texas A&M University |
| 9:45 pm |
Poster Session II (A-I continued) |
| Tuesday, January 26 |
| Morning |
NiFe and Fe-Hydrogenases |
|
Marcetta Darensbourg, Texas A&M University, Chair |
| 8:45-9:00 am |
"X-ray Structure of Fe-only Hydrogenase I from C. pasteurianum"
John Peters, Utah State University |
| 9:00-9:15 am |
The 1.6 Å Resolution Structure of the Fe-only Hydrogenase from Desulfovibrio desulfuricans
Juan C. Fontecilla-Camps, CEA, CNRS, Grenoble |
| 9:30-10:00 am |
"Hydrogenases: Ancient Catalysts with CO, CN, and/or Fe Wrapped up in Protein"
Simon Albracht, University of Amsterdam |
| 10:10-10:20 am |
Marcetta Darensbourg |
| 10:20-10:45 am |
Break |
| 10:45-11:15 am |
"Infrared Spectroscopy as a Probe of Active Site Structure and Molecular Mechanism in the [Ni,Fe] Hydrogenases"
Kimberley Bagley, State University College of New York at Buffalo |
| 11:25-11:55 am |
"A Venture into the Chemistry of Nickel-Sulfur Centers: Viable Models for the Active Site of Hydrogenase Enzymes"
Michelle Millar, SUNY Stony Brook |
| 12:05 pm-12:35 pm |
"Models for the [Fe(CO)(CN)] Centers in Hydrogenase Enzymes -- Why did Nature Choose Such a Vile Combination of Ligands?"
Stephen Koch, SUNY Stony Brook |
| Evening |
The Emergence of Life |
| 7:30-8:05 pm |
"Metal Sulfides, Metalloenzymes and the Emergence of the First
Metabolist at a Submarine Hydrothermal Seepage at ~4.2 Ga"
Mike Russell, University of Glasgow |
| 8:20-8:50 pm |
"Metallo Enzymes in Methanogenic Archaea"
Rudolf Thauer, Max-Planck-Institut für Terrestrische Mikrobiologie |
| 9:15 pm |
Poster Session III (J-Z) |
| Wednesday, January 27 |
| Morning |
Valence Delocalization and Electron Transfer |
|
Harry Gray, CalTech, Chair |
| 8:45-9:15 am |
"New Functional Aspects of Old Electron Transport Clusters: A Theoretical Approach to the Effects of Spin and Valence Delocalization on the Rate of Long-range Electron Transfer"
Emile Bominaar, Carnegie Mellon University |
| 9:30-10:00 am |
"Electron Delocalization and Electronic Transfer in Copper and Iron
Active Sites"
Edward I. Solomon, Stanford University |
| 10:15-10:45 |
Break |
| 10:45-11:15 am |
"Probing the Connection Between Heisenberg Spin Exchange and the
Dynamics of Photo-Induced Electron Transfer"
Jim McCusker, University of California at Berkeley |
| 11:30-12:00 |
"New High-valent Iron Complexes: Generation and Characterization of Nitridoiron(V)"
Karl Wieghardt, Max Planck Institut für Strahlenchemie |
| 5:00 pm |
Conference Organization Committee (MIB Chairs) |
| Evening |
Cu Systems |
|
David M. Dooley, Montana State University, Chair |
| 7:30-8:00 pm |
"A Protein Analog Approach to Biomimetic Studies of Metal-binding Sites in Cytochrome c Oxidase"
Yi Lu, University of Illinois |
| 8:00-8:30 pm |
"Studies of Particulate Methane Monooxygenase"
Sunney Chan, CalTech |
| 8:45-9:10 pm |
"Development of High Frequency EPR and ENDOR for Protein Structure Studies"
Christian Farrar, MIT |
| 9:15 pm |
Poster Session IV (J-Z continued) |
| Thursday, January 28 |
| Evening |
Zn and Fe Regulation and Uptake |
|
Valeria Culotta, Johns Hopkins University, Chair |
| 8:45-9:15 am |
"Oxygen Sensing and Iron Sulfur Clusters: Control of the Global Regulator FNR"
Patricia J. Kiley, University of Wisconsin |
| 9:30-10:00 am |
"Structural and Functional Studies of Enzymes of the Heme Biosynthetic Pathway"
Gloria Ferreira, University of South Florida |
| 10:00-10:15 am |
Break |
| 10:45-11:15 am |
"Regulation of Zn Homeostasis in Yeast"
David J. Eide, University of Missouri |
| 11:30-Noon |
"Role of Zinc in Mediating Neuronal Death after Brain Ischemia"
Dennis Choi, Washinton University, St. Louis |
| 5:30 pm |
Conference Business Meeting |
| Evening |
Green Oxidants (Joint Session with Gordon Research Seminar) |
| 7:30-7:40 pm |
Introduction
Eckard Münck |
| 7:40 pm |
"Design and Application of Hydrogen Peroxide Activators"
Terrence J. Collins, Carnegie Mellon University |
| 9:15 pm |
Poster Session V (Presented by Gordon Research Seminar) |
