| Sunday Afternoon |
| 2-6pm | Registration |
| Poster Set-up |
Sunday Evening
|
| (Chair: Jim Penner-Hahn) |
| 7:30 pm | VL Pecoraro | Opening Remarks |
| 7:45 pm | Elizabeth Theil | Ferritin-Something for Every Bioinorganic Chemist |
| Posters |
| Monday Morning |
| Conference Photo |
| Metals in Medicine
(Chair: Tom Meade) |
| 9:00-9:30 am | John Kozarich (Merck) | Peptide Deformylase - Structure, Function and Antimicrobial Target Potential |
| 9:45-10:15 | B. Sarkar | Copper Replacement Therapy for Menkes Disease |
| 10:30-11:00 am | BREAK |
| 11:00-11:30 am | Peter Sadler (Edinburgh) | Activation and targeting of metal-based therapeutic agents |
| 11:45-12:15 am | Samuel A. Wickline | Molecular and Cellular Imaging of the Cardiovascular system |
| Monday Evening |
| Metal-Sulfur Proteins
(Chair: John Enemark) |
| 7:30-8:00 pm | Barbara Burgess | Ferredoxin I and an Oxidative Stress Response in Azotobacter vinelandii |
| 8:15-8:45 pm | Marty Kirk | A Molecular Level Description of
Electron and Atom Transfer in Pyranopterin Molybdenum Enzymes |
| 9:00-9:30 pm | Cathy Drennen | How to live on carbon monoxide: the X-ray structure of nickel-dependent carbon monoxide dehydrogenase from R. rubrum |
| Tuesday Morning |
| Ion Transport and Assembly
(Chair: Tom O'Halloran) |
| 8:30-9:00 am | Lucia Banci | Structural characterization in solution of copper chaperonins |
| 9:15-9:45 am | Amy Rosenzweig | New Crystal Structures of Metallochaperone Proteins |
| 10:00-10:15 am | Break |
| 10:15-10:45 am | Val Culotta | Intracellular trafficking of manganese ions |
| 11:00-11:30 pm | JoAnne Stubbe | Yeast Ribonucleotide Reductase: Y4 required for Y2 diiron cluster assembly |
| 11:45-12:15 | Barry Rosen | Crystal structure of two arsenic enzymes: the ArsA arsenite-translocating ATPase and the ArsC arsenate reductase |
| Tuesday Evening |
| Metalloradical Enzymes
(Chair: Peter Kroneck) |
| 7:30-8:00 pm | Bernt Krebs | Catechol Oxidase-Its Structure and Function in Relation to Hemocyanin and Tyrosinase |
| 8:15-8:45 pm | Bill Tolman | Coordinatively Unsaturated Complexes of Cu as Models of Reactive States of Metalloprotein Active Sites |
| 9:00-9:30pm | Michael K. Chan | Bioinorganic Protein Crystallography: From Signal Transduction to Molecular Enzymology |
| Wednesday Morning |
| Designed Systems
(Chair: John Groves) |
| 8:30 -9:00am | Trevor Douglas | Materials and Molecular Interactions at the Protein-Solution Interface |
| 9:15-9:45am | Stefan Matile | Biomimetic Molecular Rods |
| 10:00-10:30 | Break |
| 10:30-11:00am | Brian Gibney | Engineering Ferredoxin Maquettes for Modular Metalloprotein Design |
| 11:15-11:45am | Bill DeGrado | De Novo Design of Model Diiron Proteins |
| Wednesday Evening |
| Theoretical Approaches to Understanding Metals in Biology
(Chair: Michael Hall) |
| 7:30-8:00 pm | Rich Friesner | Large Scale Quantum Chemical Modeling of Metalloprotein Active Sites |
| 8:15-8:45 pm | Sharon Hammes-Schiffer | Theoretical Perspectives on Proton-Coupled Electron Transfer |
| 9:00-9:30 pm | Lou Noodleman | Iron-sulfur Proteins: Electronic
Structure, Energetics, and Cluster-Protein Interactions |
| Thursday Morning |
| Heme and Corrin Enzymes
(Chair: Ruma Banerjee) |
| 8:30 -9:00am | Christoph Kratky | Radical generation and radical propagation in a coenzyme B12 dependent enzyme: the 3D structure of glutamate mutase |
| 9:15-9:45am | Neil Marsh | Adenosylcobalamin: Nature's Radical Catalyst |
| 10:00-10:15 | Break |
| 10:15-10:45 | Ann Walker | Novel NO-Releasing Heme Proteins from the Saliva of Blood-Sucking Insects |
| 11:00-11:30 | P. Ortiz de Montellano | Heme Oxygenase Structure and Mechanism |
| 11:45-12:15 | Tom Poulos | Crystallographic Structures of Nitric Oxide Synthase Heme Domains |
| Thursday Afternoon |
| 4:30 pm | Business Meeting |
| Thursday Evening |
| Joint Session with Gordon Research Seminar
(Chairs: Tom Spiro and Harry Gray) |
| 7:30 pm | | A Rememberance: Paul Saltman |
| (Chair: Vincent L. Pecoraro) |
| 7:50 pm | Stephen Lippard | Cisplatin: From DNA Damage to
Anticancer Activity |
