| Sunday, January 21 |
| 2:00 - 6:00 p.m. | Registration |
| 4:00 p.m. | Poster Session |
| 6:00 p.m. | Dinner |
| 7:30 - 7:45 p.m. | Introduction
Chair, Barbara K. Burgess (UC Irvine) & Carlyle Storm (GRC) |
| "Metalloenzyme structure/function design" |
| John H. Enemark, University of Arizona,Chair |
| 7:45 - 8:45 p.m. | Elizabeth Getzoff, Scripps Research Institute
"Metalloprotein structure/function design" |
| 9:00 p.m. | Chair's Reception/Poster Session |
| Monday, January 22 |
| 8:30 a.m. | Conference Photo |
| "Coupled Electron Transfer" |
| Harry B. Gray, Cal Tech, Chair |
| 9:00 - 9:30 a.m. | Fraser Armstrong, University of Oxford
" Deconvoluting complex ET reactions" |
| 9:45 - 10:15 a.m. | Les Dutton, University of Pennsylvania
"Electron tunneling and coupled events in redox chains
and biological oxidation-reduction" |
| 10:30 -11:00 a.m. | Break |
| 11:00 -11:30 a.m. | George L. McLendon, Princeton
"First principles design of redox proteins" |
| 11:45 -12:15 p.m. | Daniel G. Nocera, MIT
"Measurements of proton-coupled electron transfer reactions
in biomimetic and natural systems" |
|
"Metalloenzyme Mechanism" |
| Pradip Mascharak, UC Santa Cruz, Chair |
| 7:30 - 8:00 p.m. | Julie Kovacs, University of Washington
"Modeling the structure and reactivity of nitrile hydratases.
Can ligand constraints hold a metal ion in an entatic state?" |
| 8:15 - 8:45 p.m. | Victoria J. Derose, Texas A & M University
"Metal-peptide models for protein active sites" |
| 9:00 -9:30 p.m. | Ted R. Holman, University of California, Santa Cruz
"Structure /function investigations of soybean
and human lipoxygenase" |
| 9:40 p.m. | Poster Session |
| Tuesday, January 23 |
| "Metalloregulatory Proteins and Nucleotide Interactions" |
| Sheila David, University of Utah, Chair |
| 9:00 - 9:30 a.m. | Marie-Alda Gilles-Gonzalez, Ohio State
"Mechanisms of heme-mediated signal transduction" |
| 9:45 - 10:15 a.m. | Isabelle Michaud-Soret, DRFMC, CEA-Grenoble
"Spectroscopic and structural characterization of the Fur protein, iron sensor in bacteria; conformational changes of Fur upon metal activation and DNA binding" |
| 10:30 - 11:00 a.m. | Break |
| 11:00 - 11:30 a.m. | Jacqueline K. Barton, Cal Tech
"Biochemical consequences of DNA-mediated charge transport" |
| 11:45 - 12:15 p.m. | Eiichi Kimura, Hiroshima University
"Selective interaction of artificial zinc complexes with DNA and RNA for controlling gene expression " |
| "Metals in Medicine" |
| John Kozarich, Merck Corporation, Chair |
| 7:30 - 8:00 p.m. | Hilary A. Godwin, Northwestern
"Why is lead toxic?
Unraveling the molecular mechanism(s) of lead poisoning" |
| 8:15 - 8:45 p.m. | Randall Lauffer, EPIX Medical Inc.
"Biophysical Tuning and Targeting of Gadolinium (III) Chelates as Contrast Agents for MRI."
|
| 9:00 - 9:30 p.m. | David Piwnica-Worms, Washington University, St. Louis
"Technetium and Gallium Complexes for Molecular Imaging of Transporter and Protease Activities in Cancer".
|
| Wednesday, January 24 |
| "Metal uptake and chaperones" |
| Lucia Banci, University of Florence, Chair |
| 9:00 - 9:30 a.m. | Ken Raymond, University of California, Berkeley
" The siderophore shuttle:
a new kind of membrane transport process " |
| 9:45 - 10:15 a.m. | Alison Butler, University of California, Santa Barbara
"Self-assembling amphiphilic siderophores from marine bacteria:
Mechanisms of iron acquisition by marine microorganisms" |
| 10:30 - 11:00 a.m. | Break |
| 11:00 - 11:30 a.m. | Nancy Andrews, Harvard Medical School
"Mouse models of human iron disorders" |
| 11:45 - 12:15 p.m. | Thomas V. O'Halloran, Northwestern University
"Inorganic cell biology of metallochaperones
and metalloregulatory proteins" |
| "Active Site Assembly" |
| Rachel Austin, Princeton, Chair |
| 7:30 - 8:00 p.m. | Dennis Dean, Virginia Tech
"Biosynthesis of iron-sulfur clusters" |
| 8:15 - 8:45 p.m. | Hermann Schindelin, SUNY, Stonybrook
"Biosynthesis of the molybdenum cofactor - a conserved pathway with interesting evolutionary relationships" |
| 9:00 - 9:30 p.m. | C. David Stout, Scripps Research Institute
"[Fe-S] cluster assembly in the aconitase active site" |
| 9:45 p.m. | Poster Session |
| Thursday, January 25 |
| "Metalloenzymes in metabolism" |
| Martha Ludwig, University of Michigan, Chair |
| 9:00 -9:30 a.m. | Ruma Banerjee, University of Nebraska, Lincoln
"Regulation of human cystathionine beta synthase activity
by CO and NO: Possible role for this hemeprotein in CO sensing" |
| 9:45 - 10:15 a.m. | So Iwata, Uppsala University
"Current progress in the structural studies on the
cytochrome bc1 complex"
|
| 10:30 - 11:00 a.m. | Break |
| 11:00 - 11:30 a.m. | Shinya Yoshikawa, Himeji Institute of Technology
"X-ray structure and reaction mechanism of
bovine heart cytochrome c oxidase" |
| 11:45 - 12:15 p.m. | Shelagh Ferguson-Miller, Michigan State
"How electrons get in and protons get out in cytochrome c oxidase" |
| 5:00 p.m. | Conference Business Meeting |
| Joint Session with Gordon Research Seminar |
| Barbara Burgess, University of California, Irvine, Chair |
| 7:30 - 7:40 p.m. | Introduction: Richard Holm, Harvard University |
| 7:50 - 8:50 p.m. | "Bioinorganic chemistry of molybdenum and tungsten:
Oxotransferases" |
| 9:15 p.m. | Poster Session (Presented by Gordon Research Seminar) |
