| SUNDAY |
| 2:00 - 6:00 PM | Registration & Poster Set Up |
| 6:00 - 7:15 PM | DINNER |
| 7:25 PM | Welcome & Introductory Remarks
Dr. T. O'Halloran (Northwestern University), Chair |
| METALS, PROTEINS AND DISEASE |
| Discussion Leader: Dr. S. Lippard (MIT) |
| 7:45 - 8:30 PM | Dr. G. Brewer (University of Michigan-Ann Arbor)
The War Against Copper: From Wilson's Disease to Cancer Therapy |
| 8:30 - 8:40 PM | Discussion |
| 8:40 - 9:00 PM | In Honor of Barbara Burgess
Tom Poulos (University of California-Irvine)
Dick Holm (Harvard) |
| 9:00 PM | Chair's Reception/Poster Session |
| MONDAY |
| 7:30 - 8:30 AM | BREAKFAST |
| 8:30 - 9:00 AM | Conference Photo |
| SUPEROXIDE AND METALS |
| Discussion Leader: Dr. V. Culotta (Johns Hopkins University) |
| 9:00 - 9:35 AM | Dr. I. Fridovich (Duke University)
SODs: Nitroxyl oxidoreductase activity and complimentation manganese |
| 9:35 - 9:45 AM | Discussion |
| 9:45 - 10:15 AM | Dr. J. Valentine (University of California-Los Angeles)
SOD and Amyotrophic Lateral Sclerosis |
| 10:15 - 10:25 AM | Discussion |
| 10:25 - 10:45 AM | BREAK |
| 10:45 - 11:15AM | Dr. D. Riley (MetaPhore, Inc., St. Louis, Missouri)
Design of Selective SOD Enzyme Mimetics (EM) and Their Utility in Cancer Therapy |
| 11:15 - 11:25 AM | Discussion |
| 11:25 - 11:55 PM | Dr. D. Kurtz (University of Georgia-Athens)
Microbial Non-heme Iron Proteins that Combat Oxidative Stress |
| 11:55 - 12:05 PM | Discussion |
| 12:05 - 12:20 PM | Dr. P. Basu (Duquesne University - Pittsburgh)
Nitrate reductase and oxygen atom transfer reaction |
| 12:20 - 12:30 PM | Discussion |
| 12:30 - 1:30 | LUNCH |
| 4:30 - 6:00 PM | Poster Session |
| 6:00 - 7:30 PM | DINNER |
| IRON AND SULFUR CLUSTERS: ASSEMBLY AND FUNCTION |
| Discussion Leader: Dr. D. Holm (Harvard) |
| 7:30 - 8:05 PM | Dr. T. Rouault (National Institutes of Health, Bethesda, Maryland)
Regulation of mammalian iron metabolism |
| 8:05 - 8:15 PM | Discussion |
| 8:15 - 8:50 PM | Dr. J. Broderick 2002 Paul
Saltman Lecturer (Michigan State University-East Lansing)
Radical Roles for Iron-Sulfur Clusters |
| 8:50 - 9:00 PM | Discussion |
| 9:00 - 9:35 PM | Dr. L. Vickery (University of California-Irvine)
The Fe/S-cluster assembly complex |
| 9:35 - 9:45 PM | Discussion |
| 9:45 PM | Poster Session |
| TUESDAY |
| 7:30 - 8:30 AM | BREAKFAST |
| BIOINORGANIC MATERIALS IN SENSING, IMAGING AND ELECTRONICS |
| Discussion Leader: Dr. J. Caradonna (Boston University) |
| 9:00 - 9:35 AM | Dr. A. Belcher (University of Texas-Austin)
Biomineralization of Novel Inorganic Materials |
| 9:35 - 9:45 AM | Discussion |
| 9:45 - 10:15 AM | Dr. H. Hellinga (Duke University)
Rational design of Receptors and Redox based Sensors |
| 10:15 - 10:30 AM | Discussion |
| 10:30 - 10:45 AM | BREAK |
| 10:45 - 11:15 AM | Dr. J. Zaleski (Indiana University-Bloomington)
Designing Transition Metal Activated Diradical Intermediates:
Approaches Toward Inorganic Biochemical Agents |
| 11:15 - 11:25 AM | Discussion |
| 11:25 - 11:55 AM | Dr. T. Meade (Caltech)
Molecular Imaging of Cellular Processes by Magnetic Resonance |
| 11:55 - 12:05 PM | Discussion |
| 12:05 - 12:20 PM | Dr. S. Watton (Virginia Commonwealth University - Richmond)
Silica-immobilized copper phenanthrolines as supported biomimetic catalysts |
| 12:20 - 12:30 PM | Discussion |
| 12:30 - 1:30 PM | LUNCH |
| 4:30 - 6:00 PM | Poster Session |
| 6:00 - 7:30 PM | DINNER |
| MICROBIAL NICKEL AND COPPER CHEMISTRY |
| Discussion Leader: Dr. S. Franklin (University of Iowa-Iowa City) |
| 7:30 - 8:05 PM | Dr. M. Maroney (University of Massachusetts-Amherst)
Nik at Nite |
| 8:05 - 8:15 PM | Discussion |
| 8:15 - 8:50 PM | Dr. C. Riordan (University of Delaware-Newark)
Dioxygen Activation by Low Valent Nickel Complexes |
| 8:50 - 9:00 PM | Discussion |
| 9:00 - 9:35 PM | Dr. D. Dooley (Montana State University-Bozeman)
New Proteins in the Assembly of Nitrous Oxide Reductase |
| 9:35 - 9:45 PM | Discussion |
| 9:45 PM | Poster Session |
| WEDNESDAY |
| 7:30 - 8:30 AM | BREAKFAST |
| COFACTOR CHEMISTRY IN METALLOENZYME CATALYSIS |
| Discussion Leader: Dr. V. DeRose (Texas A&M) |
| 9:00 - 9:35 AM | Dr. C. Fierke (University of Michigan-Ann Arbor)
The catalytic roles of metal ions in protein farnesyltransferase |
| 9:35 - 9:45 AM | Discussion |
| 9:45 - 10:20 AM | Dr. J. Penner-Hahn (University of Michigan-Ann Arbor)
Zinc promoted alkyl transfer enzymes |
| 10:20 - 10:30 AM | Discussion |
| 10:30 - 10:45 AM | BREAK |
| 10:45 - 11:20 AM | Dr. A. Walker (University of Arizona-Tucson)
Iron Complexes of the Non-Innocent Corrolate Macrocycle |
| 11:20 - 11:25 AM | Discussion |
| 11:25 - 11:55 AM | Dr. B. Hoffman (Northwestern University)
Heme enzyme hydroxylation mechanism by EPR/ENDOR |
| 11:55 - 12:05 PM | Discussion |
| 12:05 - 12:20 PM | Dr. L. Berreau (Utah State University - Logan)
Nitrogen sulfur-ligated zinc hydroxide, alcohol and aryloxide complexes possessing an internal hydrogen bond donor |
| 12:20 - 12:30 PM | Discussion |
| 12:30 - 1:30 PM | LUNCH |
| 4:30 - 6:00 PM | Poster Session |
| 6:00 - 7:30 PM | DINNER |
| METAL VS. LIGAND ACTIVATION IN OXIDATION CATALYSTS |
| Discussion Leader: Dr. W. Tolman (University of Minnesota-Minneapolis) |
| 7:30 - 8:05 PM | Dr. A. Borovik (University of Kansas-Lawrence)
The Use of Bio-Inspired Organic Frameworks in Stabilizing Metal Complexes
with Terminal Oxo and Hydroxo Ligands |
| 8:05 - 8:15 PM | Discussion |
| 8:15 - 8:50 PM | Dr. J. Mayer (University of Washington-Seattle)
What makes an active site reactive toward hydrogen atom abstraction? |
| 8:50 - 9:00 PM | Discussion |
| 9:00 - 9:35 PM | Dr. J. Groves (Princeton)
The Non-Heme Diiron Alkane Monooxygenase of Pseudomonas oleovorans (AlkB) Hydroxylates via a Substrate Radical Intermediate |
| 9:35 - 9:45 PM | Discussion |
| 9:45 PM | Poster Session |
| THURSDAY |
| 7:30 - 8:30 AM | BREAKFAST |
| SPECIFICITY IN METALLOCHAPERONES AND METALLOREGULATORY PROTEINS |
| Discussion Leader: Dr. Elizabeth Theil (CHORI, Oakland, Calif.) |
| 9:00 - 9:35 AM | Dr. N. Robinson (University of Newcastle, U.K.)
Selectivity in bacterial metal homeostasis |
| 9:35 - 9:45 AM | Discussion |
| 9:45 - 10:20 AM | Dr. D. Giedroc (Texas A & M-College Station)
Prokaryotic Metal Sensor Proteins: Bioinorganic Chemistry and Allosteric Regulation |
| 10:20 - 10:30 AM | Discussion |
| 10:30 - 10:45 AM | BREAK |
| 10:45 - 11:20 AM | Dr. D. Winge (University of Utah-Salt Lake City)
Three Proteins involved in the Metallation of Copper Centers Cytochrome c Oxidase |
| 11:20 - 11:25 AM | Discussion |
| 11:25 - 11:55 AM | Dr. I. Bertini (University of Florence, Italy)
A structural genomics approach to copper trafficking |
| 11:55 - 12:05 PM | Discussion |
| 12:05 - 12:20 PM | Dr. R. Austin (Bates College - Lewiston, Maine)
An emerging bioinorganic perspective on hydrocarbon transformations in the carbon cycle |
| 12:20 - 12:30 PM | Discussion |
| 12:30 - 1:30 PM | LUNCH |
| 5:15 - 6:00 PM | Business Meeting |
| 6:00 - 7:30 PM | BANQUET (joint with Gordon Research Seminar) |
| Joint Session with Gordon Research Seminar |
| 7:30 - 7:35 PM | Introduction - Dr. T. O'Halloran (Northwestern University), Chair |
| 7:35 - 8:35 PM | Dr. H. Gray (Caltech)
Electron Tunneling Wires for Metalloproteins |
| 8:35 - 8:45PM | Discussion |
| 8:45PM | Poster Session (Presented by Gordon Research Seminar) |
