| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SEARCHING SEQUENCES FOR POTENTIAL METAL-BINDING SITES |
| Discussion Leader: Richard H. Holm (Harvard University) |
| 7:30 pm - 8:30 pm | Jeremy M. Berg (National Institute of General Medical Sciences)
“Searching Genomes for and with Zinc-Binding Domains” |
| 8:45 pm - | Chair's Reception and Poster Session (Poster Presenters A-H) |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | METALLONEUROCHEMISTRY |
| Discussion Leader: Carol Fierke (University of Michigan) |
| 9:00 am - 9:30 am | Stephen J. Lippard (Massachusetts Institute of Technology)
"Metalloneurochemistry: Fluorescent Probes for Zinc, Mercury, and Nitric Oxide" |
| 9:45 am - 10:15 am | Chris Frederickson (Neurobiotex)
"Synaptic and Somatic Release of Zinc" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Alan Kay (University of Iowa)
"Is Synaptic Zinc Really Released?" |
| 11:45 am - 12:15 pm | Thomas V. O'Halloran (Northwestern University)
"Inorganic Physiology of Zinc: Insights from Chemical and Biological Metal Sensors" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Poster Presenters A-H) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IRON TRANSPORT AND STORAGE IN METABOLISM AND DISEASE |
| Discussion Leader: Seth Cohen (UC San Diego) |
| 7:30 pm - 8:00 pm | Elizabeth C. Theil (Children's Hospital of Oakland Research Institute)
"New Twists in Managing Iron and Oxygen - The Ferritin Nanoreactor" |
| 8:15 pm - 8:45 pm | Kenneth N. Raymond (UC Berkeley)
"Microbial Iron Transport and Human Disease" |
| 9:00 pm - | Poster Session (Poster Presenters A-H) |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEIN FOLDING, MISFOLDING AND DISEASE |
| Discussion Leader: Jay Winkler (California Institute of Technology) |
| 9:00 am - 9:30 am | Ashley I. Bush (Harvard Medical School)
"The Metallobiology of Alzheimer's Disease" |
| 9:45 am - 10:15 am | Kara L. Bren (University of Rochester) (2004 SALTMAN LECTURER)
"Cytochrome c Folding and Dynamics Probed by NMR" |
| 10:30 am | Coffee Break |
| Discussion Leader: Kevin Plaxco (UC Santa Barbara) |
| 11:00 am - 11:30 am | Tobin R. Sosnick (University of Chicago)
"Discerning the Structure and Energy of Multiple Transition States in Protein Folding Using Designed Metal Binding Sites and ψ-Analysis" |
| 11:45 am - 12:15 pm | Harry B. Gray (California Institute of Technology)
"Mapping Metalloprotein Folding Landscapes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Poster Presenters I-Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | METALS, PROTEINS, NUCLEIC ACIDS AND SENSORS |
| Discussion Leader: Victoria DeRose (Texas A&M University) |
| 7:30 pm - 8:00 pm | Yi Lu (University of Illinois)
"New Metallo-DNAzymes: From Fundamental Insights into Metal-binding Sites in Nucleic Acids to Practical Application as Metal Ion Sensors" |
| 8:15 pm - 8:45 pm | Robert A. Scott (University of Georgia)
"The Zinc Ribbon Motif in Transcription Initiation" |
| 9:00 pm - 9:20 pm | Christoph Fahrni (Georgia Institute of Technology)
SHORT TALK: “Rational Design of Fluorescent Sensors for the Biological Chemistry of Copper |
| 9:30 pm - | Poster Session (Poster Presenters I-Z) |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ENVIRONMENTAL BIOINORGANIC CHEMISTRY |
| Discussion Leader: Edward I. Stiefel (Princeton University) |
| 9:00 am - 9:30 am | Dianne K. Newman (California Institute of Technology)
"How Bacteria Respire Minerals" |
| 9:45 am - 10:15 am | Bradley M. Tebo (Scripps Institution of Oceanography, UC San Diego)
"Unraveling Bacterial Mn(II) Oxidation Step by Step: Molecular Mechanisms, Reaction Intermediates and Products" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Francois M. M. Morel (Princeton University)
"Unusual Use of Trace Metals to Sustain the Productivity of the Oceans" |
| 11:45 am - 12:15 pm | Walter Schaffner (University of Zurich)
"Heavy Metal Stress Response from Insects to Mammals" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (Poster Presenters I-Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NITROGENASE MIMETIC CHEMISTRY |
| Discussion Leader: Julia A. Kovacs (University of Washington) |
| 7:30 pm - 8:00 pm | Richard R. Schrock (Massachusetts Institute of Technology)
"Catalytic Reduction of Dinitrogen at a Single Molybdenum Center"
|
| 8:15 pm - 8:35 pm | Sonny C. Lee (Harvard University)
SHORT TALK
"Weak-Field Iron and Nitrogen Anions: Synthetic Cluster Chemistry and the Nitrogenase Problem" |
| 8:45 pm - 9:05 pm | Jonas C. Peters (California Institute of Technology)
SHORT TALK
"Dinitrogen Chemistry from Trigonally Coordinated Iron Platforms" |
| 9:15 pm - | Poster Session (Poster Presenters I-Z) |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MECHANISTIC CHEMISTRY OF FeHEME ENZYMES |
| Discussion Leader: David M. Dooley (Montana State University) |
| 9:00 am - 9:30 am | John H. Dawson (University of South Carolina)
"Oxygen Activation by Cytochrome P450: Mechanistic Evidence from Studies with P450-CAM as a Model System" |
| 9:45 am - 10:15 am | Isao Morishima (Kyoto University)
"Molecular Mechanism of P450cam Catalyzed Oxygenation Reaction Regulated by the Association with Putidaredoxin" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 pm | Angela Wilks (University of Maryland)
SHORT TALK
"Heme Transfer to Heme Oxygenase: Characterization of a Bacterial Heme Chaperone and Its Role in Pathogenesis" |
| 11:30 am - 11:50 pm | Eric Hegg (University of Utah)
SHORT TALK
"Heme A Biosynthesis: Unraveling the Unusual Oxidative Mechanism" |
| 12:00 pm - 12:20 pm | C.S. Raman (University of Texas Medical School)
SHORT TALK: "Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum"
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session Gordon Research Seminar Poster Presentations |
| 5:15 pm - 6:00 pm | Business Meeting |
| 6:00 pm | Banquet (Joint with the Gordon Research Seminar) |
| 7:30 pm - 9:30 pm | JOINT SESSION WITH THE GORDON RESEARCH SEMINAR |
| Discussion Leader: Harry B. Gray (California Institute of Technology) |
| Introductory Remarks: Alison Butler (UC Santa Barbara) |
| 7:30 pm - 8:30 pm | George L. McLendon (Princeton University)
"Cytochrome c and the Suicide Hot Line" |
| 9:00 pm - | Poster Session of the Gordon Research Seminar Posters |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
