| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | Opening Session |
| 7:30 pm - 7:45 pm | John H. Dawson, Conference Chair, University of South Carolina & Nancy Ryan Gray, Director, GRC
Introduction |
| Chair: Robert A. Scott, University of Georgia |
| 7:45 pm - 8:45 pm | Judith P. Klinman, University of California at Berkeley
"Mechanisms of Enzymatic Activation of Dioxygen" |
| 9:00 pm | Chair's Reception / Poster Session |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo |
| 9:00 am - 12:30 pm | Non-Heme Iron |
| Chair: Stephen J. Lippard, Massachusetts Institute of Technology |
| 9:00 am - 9:30 am | Lawrence Que, University of Minnesota
"New Features in the Oxoiron(IV) Reaction Landscape" |
| 9:45 am - 10:15 am | Julie A. Kovacs, University of Washington
"Understanding the Mechanism of Superoxide Reduction by the Cysteinate-Ligated Non-Heme Iron Enzyme Superoxide Reductase" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Pär Nordlund, Stockholm University
"Radical Generation in Ribonucleotide Reductases" |
| 11:45 am - 12:15 pm | Robert P. Hausinger, Michigan State University
"Fe(II)/alpha-Ketoglutarate-Dependent Hydroxylases" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Spectroscopic Methods and Intermediates |
| Chair: Peter M. Kroneck, University of Konstanz |
| 7:30 pm - 8:00 pm | W. Robert Scheidt, University of Notre Dame
"Nuclear Resonance Vibrational Spectroscopy" |
| 8:15 pm - 8:35 pm | Michael T. Green, Pennsylvania State University
SHORT TALK, "The Role of Thiolate-Ligation in Cytochrome P450" |
| 8:40 pm - 9:00 pm | Carsten Krebs, Pennsylvania State University
SHORT TALK, "A High-Spin Non-Heme Iron(IV)-Oxo Intermediate in an Alpha-Ketoglutarate-Dependent Hydroxylase" |
| 9:05 pm - 9:25 pm | Ulrich Weser, Universität Tübingen
"Bioinorganic Archaeology: Active Zinc- Enzymes in the Mummies of the Egyptian Pharaohs" |
| 9:30 pm | Poster Session |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cytochrome c Oxidase |
| Chair: Ólöf Einarsdóttir, University of California at Santa Cruz |
| 9:00 am - 9:30 am | Mårten Wikström, University of Helsinki
"The Elusive Proton Pumping Mechanism of Cytochrome c Oxidase" |
| 9:45 am - 10:15 am | Shelagh M. Ferguson-Miller, Michigan State University
"Electron and Proton Transfer in Cytochrome c Oxidase" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | James P. Collman, Stanford University
"Functional Models for Cytochrome c Oxidase: The Mechanism of Oxygen Reduction Under Conditions of Rate-Limiting Electron Transfer" |
| 11:45 am - 12:15 pm | Kenneth D. Karlin, Johns Hopkins University
"Ligand Influences in Heme-Copper Dioxygen Chemistry" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metalloenzyme Intermediates |
| Chair: John T. Groves, Princeton University |
| 7:30 pm - 8:00 pm | Brian M. Hoffman, Northwestern University
"Characterizing the Invisible: Enzyme Intermediates by EPR/ENDOR" |
| 8:15 pm - 8:45 pm | Stephen G. Sligar, University of Illinois
"Are There Any Remaining Questions in Cytochrome P450 Mechanisms?" |
| 9:00 pm - 9:20 pm | Michael E.P. Murphy, University of British Columbia
SHORT TALK, "Copper-Nitrosyl Coordination by Nitrite Reductase" |
| 9:30 pm | Poster Session |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Copper Enzymes |
| Chair: Michele A. McGuirl, University of Montana |
| 9:00 am - 9:30 am | David M. Dooley, Montana State University
"The Assembly and Function of Copper Sites in Amine Oxidases, Galactose Oxidase, and Nitrous Oxide Reductase" |
| 9:45 am - 10:15 am | Hans C. Freeman, University of Sydney
"Xenon as a Structural Probe for Potential O2 Binding Sites in Amine Oxidases" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Carrie M. Wilmot, University of Minnesota
"Structural Insights into Dioxygen Activation in Copper-Containing Amine Oxidase" |
| 11:45 am - 12:15 pm | Edward I. Solomon, Stanford University
"O2 and N2O Activation by Binuclear, Trinuclear and Tetranuclear Cu Centers" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metals and Medicine |
| Chair: Thomas Meade, Northwestern University |
| 7:30 pm - 8:00 pm | Peter J. Sadler, University of Edinburgh
"The Role of Metal Complexes in Disease Treatment" |
| 8:15 pm - 8:45 pm | Jan Reedijk, Leiden Institute of Chemistry
"Metal-DNA Interaction: Inspiration for New Antitumor Drugs" |
| 9:00 pm - 9:20 pm | Claudia Turro, Ohio State University
SHORT TALK, "Excited State Properties of Transition Metal Complexes: DNA Binding, Photocleavage, and Photoinduced Cytotoxicity" |
| 9:30 pm | Poster Session |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Metals and Nucleic Acids |
| Chair: Sonya J. Franklin, University of Iowa |
| 9:00 am - 9:30 am | Joseph A. Piccirilli, University of Chicago
"Metal Ion Coordination and Function in Ribozymes" |
| 9:45 am - 10:15 am | Victoria J. DeRose, Texas A & M University
"Metal Ion Binding to Catalytic RNA Molecules" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Janet R. Morrow, State University of New York at Buffalo
"The Role of Metal Ions in the Cleavage of RNA and as Luminescent Probes of RNA Environment" |
| 11:45 am - 12:15 pm | Thomas D. Tullius, Boston University
"The Genome in Three Dimensions: Using Metals to Map DNA Structure" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Joint Poster Session (presented by Gordon Research Seminar) |
| 5:00 pm | Conference Business Meeting |
| 6:00 pm | Dinner |
| 7:30 pm - 8:30 pm | Joint Session with Gordon Research Seminar |
| Chair: John H. Dawson, University of South Carolina |
| 7:30 pm - 8:30 pm | JoAnne Stubbe, Massachusetts Institute of Technology
"Ribonucleotide Reductases: Something for Everyone" |
| 8:45 pm - 10:30 pm | Joint Poster Session (presented by Gordon Research Seminar) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
