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Metals in Biology

Gordon Research Conference

January 27 - February 1, 2008
Chair Julie A. Kovacs
Vice Chair Peter M. Kroneck
Four Points Sheraton / Holiday Inn Express
1050 Schooner Drive
Ventura, California, United States
 Venue and Travel Information

Conference Description

Metal ions play critical roles in over one third of all enzymes, and are involved in a number of important biosynthetic pathways. The molecular-level details regarding metalloenzyme function emerge from several complementary lines of study, at the interface of chemistry, biology, and physics. The Metals in Biology Gordon Research Conference brings together investigators with a collective expertise that spans all of these areas of research. It is one of the longest-running GRCs (starting in 1962). The consistent oversubscription of the MIB GRC prompted us in 1996 to develop the (overlapping) Gordon Research Seminar in Bioinorganic Chemistry (GRS) - the first of its kind.

Peter Kroneck will Chair the 2009 conference and John Lipscomb will Chair the 2010 conference.

Related Meeting

This GRC will be held in conjunction with the "Bioinorganic Chemistry" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

SUNDAY
4:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:45 pmJulie Kovacs (University of Washington), Chair
"Welcome & Introductory Remarks" / Comments by GRC Site Staff
7:45 pm - 9:30 pmMechanisms of Energy Conversion in Biology and Chemistry
Discussion Leader: Harry Gray (Cal Tech)
7:45 pm - 8:45 pm Cruickshank Lecturer: Daniel Nocera (MIT)
"Mechanisms of Energy Conversion in Biology and Chemistry"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:30 pmDick Holm, Eckard Munck & Peter Kroneck
"A Brief Tribute to Helmut Beinert"
9:30 pmPoster Session A / Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmO-O Bond Cleavage and Formation (Mn & Fe)
Discussion Leader: Bill Tolman (University of Minnesota)
9:00 am - 9:30 am John Groves (Princeton University)
"Reactivity and Interconversions of Oxo-, Peroxo- and Dioxo-Manganese Porphyrins"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Mike Hendrich (Carnegie Mellon University)
"Detection of Short-Lived Intermediates in the Catalytic Cycle of a Manganese Dioxygenase"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:20 am Elodie Anxolabehere-Mallart (CNRS Universite Paris-SUD)
"Intermediates of water oxidation in the OEC. Chemical and electrochemical access to Mn-oxo and Mn-peroxo model complexes"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Marlene Martinho (Carnegie Mellon University)
"Mossbauer studies of the Membrane-Associated Methane Monooxygenase from Methylococcus capsulatus bath: Evidence for a dinuclear iron center"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Masao Ikeda-Saito (Tohoku University)
"Structures of peroxo and hydroperoxo intermediates of heme proteins"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A
6:00 pmDinner
7:30 pm - 9:30 pmO-O Bond Cleavage and Formation (Cu)
Discussion Leader: Marty Bollinger (Penn State University)
7:30 pm - 8:00 pm Shelagh Ferguson-Miller (Michigan State University)
"Energy transduction by cytochrome oxidase: Importance of conserved water and conserved lipid"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Simon de Vries (Delft University of Technology)
"Tryptophan272: The heart of the cytochrome oxidase proton pump"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Edward Solomon (Stanford University)
"O2 reduction to H2O by the trinuclear Cu cluster in the multicopper oxidases"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session A
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSulfur's Influence on Metalloenzyme Function
Discussion Leader: Marty Kirk (University of New Mexico)
9:00 am - 9:30 am Charles Riordan (University of Delaware)
"Synthetic and Reactivity Studies for Understanding Organonickel Intermediates in Biocatalysis"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Sean Elliott (Boston University)
"Electrochemical Characterization of Archaeal Thioredoxins"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Mike Maroney (University of Massachusetts Amherst)
"NiSOD: A Case of Convergent Evolution"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm David Goldberg (Johns Hopkins University)
"The Impact of Thiolate |Donation on Non-Heme and Heme Synthetic Analogs: Relevance to Superoxide Reductase and Cytochrome P450"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B
6:00 pmDinner
7:30 pm - 9:30 pmSulfur's Influence on Metalloenzyme Function (Clusters)
Discussion Leader: Marcetta Darensbourg (Texas A&M University)
7:30 pm - 8:00 pm Paul Lindahl (Texas A&M University)
"Influence of Sulfur on Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase Reactivity"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Richard Holm (Harvard University)
"Aspects of the Biomimetic Chemistry of Iron, Nickel, Molybdenum, and Tungsten"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Steve Ragsdale (University of Michigan)
"Methyl-Coenzyme M Reductase: Intermediacy of Methyl-Nickel or Methyl Radical?"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session B
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOxidative Stress and Reactive Oxygen Species
Discussion Leader: Joan Valentine (UCLA)
9:00 am - 9:30 am Diane Cabelli (Brookhaven Natl. Labs)
"Functional Variations in Manganese Superoxide Dismutase"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Saltman Lecture: Chris Chang (U C Berkeley)
"Chemical Approaches to Understanding Copper and Peroxide Biology in the Brain"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Katherine Franz (Duke University)
"Inhibiting Metal-Promoted Oxidative Stress with Prochelators"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Jason Shearer (University of Nevada)
"Probing the Enzymatic Mechanism of Nickel Superoxide Dismutase Using Metallopeptide Based Models"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmMicrobial Enzymes - Living on the Edge
Discussion Leader: Peter Kroneck (University of Konstanz)
7:30 pm - 8:00 pm Arnulf Kletzin (TU Darmstadt, Germany)
"Towards a reaction mechanism for the sulfur oxygenase reductase: Conclusions from 3D structure and mutagenesis experiments"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Fred Hagen (Delft University of Technology)
"Tungsten homeostasis in Pyrococcus furiosus"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Dianne Newman (Massachusetts Institute of Techology)
"Electron transfer in times of stress: new roles for redox active 'antibiotics'"
9:20 pm - 9:30 pm Discussion
9:30 pm Poster Session B
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBio-inspired Catalysis
Discussion Leader: Jonas Peters (Massachusetts Institute of Technology)
9:00 am - 9:30 am Thomas Ward (Univ of Neuchatel, Switzerland)
"Designed evolution of artificial metalloenzymes based on the biotin-avidin technology"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Dan Stack (Stanford University)
"Development of Bio-inspired Iron and Manganese Oxidation Catalysts"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Kit Cummins (Massachusetts Institute of Technology)
"New Metal-Mediated Chemistry of the Essential Elements Nitrogen and Phosphorus"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Larry Que (University of Minnesota)
"Bio-inspired Hydrocarbon Oxidations by Nonheme Iron Catalysts"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmJoint Poster Session with Gordon Research Seminar
6:00 pmDinner
7:30 pm - 8:45 pmJoint Session with Gordon Research Seminar
Discussion Leader: Steve Lippard (Massachusetts Institute of Technology)
7:30 pm - 8:30 pm Tom O'Halloran (Northwestern University)
"Inorganic Physiology of Cancer Cell Proliferation: Targeting Copper Receptor Chemistry"
8:30 pm - 8:45 pm Discussion
8:45 pm Joint Poster Session with Gordon Research Seminar
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Contributors

Conference Links

Conference History Bioinorganic Chemistry (GRS)
Additional Fee Info

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