SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome & Introduction by Conference Chair Peter Kroneck (Universitaet Konstanz) / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | METAL SITES AT ATOMIC RESOLUTION - A TRIBUTE TO HELMUT BEINERT |
| Discussion Leader: M. Claire Kennedy (Medical College of Wisconsin) |
7:45 pm - 8:25 pm | John D. Lipscomb (University of Minnesota) "Learning from Helmut: If you speak too loud, you might not hear the
answer" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Paola Turano (University of Florence)
"Learning about ferritin through NMR" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:35 pm | Harry Gray (Caltech) & Dave Dooley (Montana State) "Hans Freeman, Friend and Colleague" |
9:35 pm | Poster Session A / Chair’s Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | SPECTROSCOPIC AND THEORETICAL METHODS |
| Discussion Leader: John H. Enemark (University of Arizona) |
9:00 am - 9:30 am | Sason Shaik (Hebrew University of Jerusalem) "What Did We Learn From Theory on the Versatile Reactivity of Cytochrome P450 Enzymes?" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Anabella Ivancich (CNRS & CEA Saclay) "Towards understanding the structural and functional features responsible for the dual activity of heme catalase-peroxidases (KatGs)" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Thomas Brunold (University of Wisconsin-Madison) "Second-Sphere Tuning of Active-Site Properties of Mn- and Fe-Dependent Superoxide Dismutases" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Serena DeBeer George (Stanford University) "X-ray absorption and emission spectroscopies as probes of iron active sites in biology" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | METALS INTERACTING WITH DNA AND RNA |
| Discussion Leader: Kim R. Dunbar (Texas A&M University) |
7:30 pm - 8:00 pm | Jacqueline K. Barton (CALTECH)
"DNA-mediated Signaling in Repair" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Yi Lu (University of Illinois at Urbana-Champaign) "Biochemical and biophysical study of metal-binding sites in DNAzymes and their applications as metal ion sensors" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Anna Pyle (Yale) "The crystal structure of an intact group II intron ribozyme reveals the basis for metal ion- catalyzed splicing in eukaryotic RNA processing" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session A |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ENVIRONMENTAL ASPECTS AND EARLY LIFE CATALYSTS |
| Discussion Leader: Alison Butler (UC Santa Barbara) |
9:00 am - 9:30 am | Kenneth N. Raymond (UC Berkeley) "Siderophore Stealth: How Anthrax and Other Pathogens Evade the Human Immune System" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Saltman Lecture: Ann Valentine (Yale) "Considering a Role for Titanium in Bioinorganic Chemistry" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Carsten Krebs (Pennsylvania State University) "Formation and Function of the Heterobinuclear Mn/Fe Cofactor of /Chlamydia trachomatis/ ribonucleotide reductase" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12.15 pm | Felisa Wolfe-Simon (Harvard University) "Geobiochemistry and Metallomic Evolution: the Differential Responses of Prokaryotes and Eukaryotes to Fe-stress and Possible Evolutionary Implications" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TRANSPORT AND CHANNELS |
| Discussion Leader: Judith P. Klinman (UC Berkeley) |
7:30 pm - 8:00 pm | Jan Saam (University of Illinois at Urbana-Champaign) "Dynamic Oxygen Access Channels in Cyclooxygenase" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Catherine L. Drennan (MIT) "Metal Selectivity of the Nickel Regulatory Protein NikR" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Dax Fu (Brookhaven National Laboratory) "Structure and mechanism of the zinc transporter YiiP" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session B |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MEDICAL ASPECTS - Targets, Diagnosis, and Therapy |
| Discussion Leader: Chris Orvig (University of British Columbia) |
9:00 am - 9:30 am | Peter Caravan (Harvard Medical School)
"Protein targeted MRI contrast agents" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Elizabeth C. Theil (CHORI)
"Going for the Iron - the Good and the Bad" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Glenn L. Millhauser (UC Santa Cruz)
"Insights into the function of a deadly protein - how the prion protein interacts with metal ions" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Stephen J. Lippard (MIT)
"Understanding and Improving Platinum Anticancer Drugs" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting: (Chair John D. Lipscomb) |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | SILENT METALS - CALCIUM AND ZINC |
| Discussion Leader: Milan Vasak (Universitaet Zuerich) |
7:30 pm - 8:00 pm | Walter J. Chazin (Vanderbilt University)
"The complex dual sensor mechanism for calcium-dependent regulation of human cardiac voltage-gated sodium channel Nav1.5" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kazuya Kikuchi (Osaka University)
"Design, Synthesis of Visualization Probes with Tunable Switches for Bio-imaging" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David L. Tierney (University of New Mexico) "Metallo-beta-Lactamases: Does Co Really Do the Same Chemistry as Zn?" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session B |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DINITROGEN AND NITROGEN OXIDE BIOCHEMISTRY |
| Discussion Leader: Lance C. Seefeldt (Utah State University) |
9:00 am - 9:30 am | Markus Ribbe (UC Irvine) "Functions of NifEN" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Patrick L. Holland (University of Rochester)
"Paramagnetic Iron Dihydrogen and Dinitrogen Complexes: How does High-Spin Iron Bind Nitrogenase Substrates?" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Michael A. Marletta (UC Berkeley) "Selective Sensing of NO in Biology: Chemistry to the Rescue" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | F. Ann Walker (University of Arizona) "Dynamics of the Nitrophorins of a New World Blood-Sucking Insect" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | JOINT SESSION WITH GORDON RESEARCH SEMINAR |
| Discussion Leader: David M. Dooley (Montana State University) |
7:30 pm - 8:30 pm | William B. Tolman (University of Minnesota)
"Biomimetic Activation of O2 and N2O by Copper" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm | Joint Poster Session with Gordon Research Seminar |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |