SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Proton and Electron Transfer in Bioinorganic Chemistry |
| Discussion Leader: Harry Gray (California Institute of Technology) |
7:40 pm - 8:20 pm | James Mayer (University of Washington)
"Moving Protons and Electrons in Biomimetic Systems"
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8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Judith Klinman (University of California, Berkeley)
"Linking Protein Motions to C-H Activation in Enzymes"
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9:15 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session I / Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Metalloenzymes and Biofuels |
| Discussion Leader: John Lipscomb (University of Minnesota) |
9:00 am - 9:30 am | Michael Marletta (The Scripps Research Institute)
"Oxidative Degradation of Cellulose"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Paul Walton (University of York)
"Copper Active Sites of Polysaccharide Oxygenases: Structural and Spectroscopic Studies"
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10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | J. Martin Bollinger, Jr. (Penn State University)
"The Mechanism of the Cryptically-Redox Oxygenation Reaction Catalyzed by Aldehyde Deformylating Oxygenase (Formerly Aldehyde Decarbonylase)"
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11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Saltman Lecture: Michelle Chang (University of California, Berkeley)
"Exploring the Bioinorganic Chemistry of Microbial Lignin Degradation"
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12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Metals and Pathogens |
| Discussion Leader: Alejandro Vila (University of Rosario) |
7:30 pm - 8:00 pm | Elizabeth Nolan (Massachusetts Institute of Technology)
"Metal-Chelating Host-Defense Proteins in Human Innate Immunity"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Celia Goulding (University of California, Irvine)
"Investigation of the Unique Mycobacterial Heme Uptake System"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Wright (Vanderbilt University)
"Hemozoin: Crystal Engineering, Heme Homeostasis and Drug Discovery in the Malaria Parasite"
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9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session I |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Manganese Oxygen Chemistry |
| Discussion Leader: Andrew Borovik (University of California, Irvine) |
9:00 am - 9:30 am | JoAnne Stubbe (Massachusetts Institute of Technology)
"The Class Ib RNRs: Metallo-cofactor Identification and Mechanism of Assembly"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Bradley Tebo (Oregon Health and Science University)
"Unraveling the Mechanism of Mn Biomineralization by Mn(II) Oxidizing Bacteria" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Stiefel Lecture: Theodor Agapie (California Institute of Technology)
"Synthetic Models of the Oxygen Evolving Complex in Photosystem II"
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11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Julie Kovacs (University of Washington)
"Metastable Mn-Peroxo Intermediates. Correlation Between Structure and Reactivity" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Environmental Bioinorganic Chemistry |
| Discussion Leader: Alison Butler (University of California, Santa Barbara) |
7:30 pm - 8:00 pm | Stephen Lippard (Massachusetts Institute of Technology)
"Control of Substrate Access to the Active Sites of Diiron Monooxygenases"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Joachim Reimann (Radboud University, Nijmegen)
"Anaerobic Methane Oxidation by Nitrite Reducing Bacteria: A New Role for NO" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Mak Saito (Woods Hole Oceanographic Institution)
"Metalloproteins in the Ocean: Strategies for Coping with Extreme Metal Scarcity"
|
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session II |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metal Homeostasis |
| Discussion Leader: Elizabeth Theil (Children's Hospital Oakland Research Institute) |
9:00 am - 9:30 am | David Giedroc (Indiana University)
"Bacterial Transition Metal Homeostasis"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Richard Bruick (University of Texas Southwestern Medical Center)
"A Mammalian Iron and Oxygen Sensor - New Dog, Old Trick?"
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10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Sabeeha Merchant (University of California, Los Angeles)
"Recycling Cu and Fe in Chloroplasts"
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11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | José Argüello (Worcester Polytechnic Institute)
"CtpC: An Uncommon P1B-type Mn2+ Transport ATPase Required for Secreted Protein Metallation in Mycobacteria"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Heme Protein Structure and Function |
| Discussion Leader: Liliya Yatsunyk (Swarthmore College) |
7:30 pm - 8:00 pm | David Goldberg (Johns Hopkins University)
"High-Valent Metal-Oxo Corrolazines: Mechanisms and Catalysis Involving HAT, OAT and O2"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ekaterina Pletneva (Dartmouth College)
"Interplay Between Redox Chemistry and Protein Conformational Dynamics: Stories of Heme Proteins"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Angela Wilks (University of Maryland)
"A Histidine-Switch Primes the Cytoplasmic Heme Chaperone of P. aeruginosa for Heme Release to Heme Oxygenase"
|
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session II / Reception in honor of Saltman and Stiefel Lecturers |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Reactivity and Biogenesis of Iron-Sulfur Clusters |
| Discussion Leader: Timothy Stemmler (Wayne State University) |
9:00 am - 9:30 am | Wayne Outten (University of South Carolina)
"The Co-Evolution of Oxygen Metabolism and Fe-S cluster Biogenesis: Insights from the Suf Pathway"
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9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Markus Ribbe (University of California, Irvine)
"Biosynthesis of Nitrogenase FeMoco"
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10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Squire Booker (Penn State University)
"Methylation of an sp2-Hybridized Carbon center in rRNA Leading to Antibiotic Resistance"
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11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Jacqueline Barton (California Institute of Technology)
"DNA Signaling among Proteins with 4Fe-4S Clusters
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12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Joint Session with Gordon Research Seminar |
| Discussion Leader: Stephen Lippard (Massachusetts Institute of Technology) |
7:30 pm - 8:30 pm | Chuan He (University of Chicago)
"Oxidative Demethylation and Selective Metal Recognition in Biology"
|
8:30 pm - 8:45 pm | Discussion |
8:45 pm | Poster Session (Joint Poster Session with Gordon Research Seminar) |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |