Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Non-Heme Iron Transformations
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Advanced Spectroscopic Studies of Homogeneous and Enzymatic Catalysts"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Expanding the Reaction Space of Nonheme Enzymes"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Control of Reaction Outcome in C–H Activation by Iron Enzymes"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Signaling through Sulfide"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Model Systems for Investigating Sulfur and Selenium Bioinorganic Chemistry"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Metal Thiolate Interactions and Divergent Sulfur Speciation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"The Role of Metal Centers in Protein Persulfidation"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
COx and NOx Signaling and Poisoning
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Polysaccharide Monooxygenases: Mechanism and Function"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"CO Sensing Transcription Factors"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Progress in the Development of a Small-Molecule Antidote for Carbon Monoxide Poisoning"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals in Signaling, Regulation and Storage
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Copper in Cell Signaling"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"National Science Foundation Inorganic Phenotypes via Quantitative Element Mapping: Case Studies in Immunology, Reproduction and Cancer"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The Amazing Facets of the Regulators of Metal Homeostasis of the FUR Family"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Multifunctional Zn Metallochaperones for Reactivation of Mutant p53"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"How Iron Enzymes Trigger Redox Sensing and Signaling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Harnessing Bioinorganic Chemistry for Energy Storage and Transduction
7:30 pm - 7:55 pm
"Bacterial Redox Circuits Mediated by Cytochromes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Multiheme Cytochromes c Enable Photocatalytic Hydrogen Production in a Nano-Bio System"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Magnetic Resonance Studies of Metalloenzymes"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"How Bacteria Manage the 2-Electron Oxidation of Mn(II) to MnO2 Bio-Mineral, Using a 1-Electron Multi-Copper Oxidase"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Using Metal Coordination Chemistry to Target and Understand Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Metal Compounds that Disrupt the Nucleolus"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Fun and Frustration in Trying to Develop Metal-Based Drugs: A Personal Account"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Metallomics for Human Health: Uncovering the Biological Roles of Biometals and Discovery of Drug Candidates"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Tools for Photocontrol Over Endogenous Metals"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Multifaced Organogold Chemistry for Therapy and Imaging"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proton Coupled Electron Transfer in Metalloproteins
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"PCET is the Engine of Radical Enzymology: The RNR Paradigm"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Proton-Coupled Electron Transfer: Fair, but Maybe Not Square"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"O2 Binding, Activation and Cleavage within Single Crystals"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Metallomics, Proteomics and Genomics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Chirality in Siderophores: Genomic Origins and Bioinorganic Consequences"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Molecular Mechanism of Transmembrane Transport of Iron"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Applications of Machine Learning to Metalloproteins"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Mn-Based Catalytic Antioxidants Known as Superoxide Dismutase Mimics: Evaluation in Cells: Bioactivity, Quantification, Speciation, Location"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Expanding the Toolbox to Track Metals in Cells: Optical and Vibrational Probes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bioinorganic Chemistry in Nature
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Nitrite Reduction by Polynuclear Iron Compounds"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Abiotic Reactions Catalyzed by Engineered Hemoprotein"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Radical SAM Enzymes: Nature’s Choice for Initiating Radical Reactions"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure