SUNDAY |
2:00 - 9:00 PM | Registration |
6:00 PM | Dinner |
SESSION 1 | "Metal Generated Radicals & Photodynamic Therapies" |
| Session Chair: John T. Groves (Princeton University) |
7:40 - 7:50 PM | Welcome from Chair & GRC |
7:50 - 8:00 PM | Introductory comments, Session Chair |
8:00 - 8:30 PM | Andrew L. Salzman (Inotek Corp.) "Medical Applications of Peroxynitrite Decomposition Catalysts" |
8:40 - 9:30 PM | Keynote Speaker, Jonathan L. Sessler (University of Texas, Austin) "Biomedical Applications of Expanded Porphyrins" |
9:45 - PM | Chair's Reception |
MONDAY |
7:30 - 8:30 AM | Breakfast |
SESSION 2 | "Metalloproteins in Disease" |
| Session Chair: Joan S. Valentine (UCLA) |
9:00 - 9:15 PM | Introductory comments, Session Chair |
9:15 - 9:45 AM | Ashley I. Bush (Massachusetts General Hospital, Boston) "Beta-Amyloid Metalloprotein as a Therapeutic Target for Alzheimer's Disease" |
10:00 - 10:15 AM | Coffee Break / Photo |
10:15 - 10:45 AM | Michael A. Marletta (Cal-Berkley) "Metal-dependent Repressors as Targets for Nitric Oxide" |
10:55 - 11:25 AM | P. John Hart (University of Texas, Health Science Center at San Antonio) "X-ray Analyses of CuZnSOD in Familial Amyotrophic Lateral Sclerosis" |
11:35 - 12:05 PM | Susan R. Doctrow (Eukarion, Inc.) "Salen Manganese Complexes as Catalytic Scavengers of Reactive Oxygen Species with Protective Activity in Models for Diseases Involving Oxidative Stress" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:00 pm | Poster Session I |
6:00 pm | Dinner |
SESSION 3 | "Metalloproteins as Targets" |
| Session Chair: Thomas J. Meade (Northwestern University) |
7:35 - 7:50 PM | Introductory comments, Session Chair |
7:50 - 8:20 PM | William G. Rice (Achillion Pharmaceuticals, Inc.) "Zinc Finger Proteins as Targets for Anti-infective Therapy" |
8:30 - 9:00 PM | Richard C. Holz (Utah State University) "A Novel Antibiotic Target: The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae" |
9:10 - 9:40 PM | Casey C. Case (Sangamo BioSciences, Inc.) "Controlling Gene Expression using Engineered Zinc Finger Proteins" |
TUESDAY |
7:30 - 8:30 AM | Breakfast |
SESSION 4 | "Radiopharmaceuticals" |
| Session Chairs: Alan Davison (MIT) & Alan Packard (Children's Hospital, Boston) |
8:45 - 9:00 PM | Introductory comments, Session Chair |
9:00 - 9:30 AM | Shuang Liu (Bristol-Myers Squibb, Co.) "Small Molecule Radiopharmaceuticals Derived from Pharmaceutical Leads" |
9:40 - 10:10 AM | Silvia S. Jurisson (University of Missouri-Columbia) "Rh-105 Complexes as Potential Therapeutic Radiopharmaceuticals" |
10:20 - 10:40 AM | Coffee Break |
10:40 - 11:10 AM | Jacquelyn C. Yanch (MIT) "The use of boron in the treatment of rheumatoid arthritis" |
11:20 - 11:50 PM | David A. Scheinberg (Memorial Sloan Kettering Cancer Center) "Therapeutic Uses of Nanogenerators of Radiometals" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
SESSION 5 | "MRI Agents" |
| Session Chair: Randall B. Lauffer (Epix Medical, Inc.) |
7:35 - 7:50 PM | Introductory comments, Session Chair |
7:50 - 8:20 PM | Silvio Aime (University of Torino) "Exploring New Routes to Improve the Contrast Enhancing Ability of Paramagnetic Agents in Cellular MRI" |
8:30 - 9:00 PM | A. Dean Sherry (University of Texas at Dallas) "Lanthanide Complexes with Slow Water Exchange May Offer Advantages in the Design of Functional MR Agents" |
9:10 - 9:40 PM | Peter Caravan (EPIX Medical) "Targeted Molecular Imaging with MRI" |
WEDNESDAY |
7:30 - 8:30 AM | Breakfast |
SESSION 6 | "Metal Complexes & Parasites" |
| Session Chair: Vijay Sharma (Washington University, St. Louis) |
8:45 - 9:00 PM | Introductory comments, Session Chair |
9:00 - 9:30 AM | Gary Posner (Johns Hopkins University) "Antimalarial Peroxides Triggered by Ferrous Iron" |
9:40 - 10:10 AM | D. Scott Bohle (University of Wyoming) "Malaria Pigment/Antimalarial Drug Interactions" |
10:20 - 10:40 AM | Coffee Break |
10:40 - 11:10 AM | David W. Wright (Vanderbilt University) "Hemozoin, Immunosuppression and Cerebral Malaria: Mechanisms for Clinical Therapies" |
11:20 - 11:50 PM | Maribel Navarro (IVIC, Venezuela) "Metal Complexes as Potential Chemotherapeutic Agents against parasitic diseases" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 3 |
6:00 pm | Dinner |
SESSION 7 | "Transport and Targeting of Metal Ions" |
| Session Chair: Peter J. Sadler (University of Edinburgh) |
7:35 - 7:50 PM | Introductory comments, Session Chair |
7:50 - 8:20 PM | Douglas Pfeiffer (Ohio State University) "The Ionophore Monensin Mediates a Rapid and Selective Transport of Pb2+ in Model and Biological Systems: Possible Application of Monensin for the Treatment of Pb2+ Intoxication" |
8:30 - 9:00 PM | Hongzhe Sun (University of Hong Kong) "Bismuth and Antimony Recognition by Peptides and Proteins: Implications for Transport and Targeting" |
9:10 - 9:40 PM | Gérard Jaouen (Ecole Nationale Supérieur de Chimie de Paris) "Targeting Organometallic Complexes onto Hormone Receptors. Therapeutic Applications" |
THURSDAY |
7:30 - 8:30 AM | Breakfast |
SESSION 8 | "Beneficial & Deleterious Effects of Transition Metal Ions" |
| Session Chair: Debbie C. Crans (Colorado State University) |
8:45 - 9:00 PM | Introductory comments, Session Chair |
9:00 - 9:30 AM | Chris Orvig (University of British Columbia) "In Vivo Coordination Chemistry: Biolocalization of Insulin-Enhancing Vanadium Complexes" |
9:40 - 10:10 AM | John B. Vincent (University of Alabama) "New Advances in the Biochemistry of Cr(III)" |
10:20 - 10:40 AM | Coffee Break |
10:40 - 11:10 AM | Peter A. Lay (University of Sydney) "New Insights into the Genotoxicity of Chromium" |
11:20 - 11:50 PM | Paul J. Kostyniak (SUNY, Buffalo) "The Importance of Chemical Form in Determining the Pharmacokinetic and Pharmacodynamic Actions of a Metal: The Case of Mercury" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:30 pm - 5:30 pm | Group Business Meeting |
6:00 pm | Banquet |
SESSION 9 | "Metal Ion - Nucleic Acid Interactions" |
| Session Chair: Trevor Hambley (University of Sydney) |
7:35 - 7:45 PM | Comments from Co-Chairs |
7:45 - 8:15 PM | Introductory comments, Session Chair |
8:25 - 9:15 PM | Capstone Lecture, Stephen J. Lippard (MIT) "Structure, Recognition, and Functional Consequences of Platinated DNA" |
9:30 PM | Closing remarks from Chair |