| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHAIR'S SESSION |
| Discussion Leader: Chris Orvig (University of British Columbia) |
| 7:30 pm - 7:45 pm | Welcome from Chair and GRC |
| 7:45 pm - 8:30 pm | Dennis Riley (Kereos)
"A Brief History of Medicinal Chemistry from an Inorganic Chemist's Perspective: From Paracelsus to the FDA" |
| 8:40 pm - 9:25 pm | Peter J. Sadler (University of Edinburgh)
"New Challenges for the Innovative Design of Medicines: From the Periodic Table to Genomes" |
| 9:30 pm | Chair's Reception / Poster Session |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TREATMENT OF IRON OVERLOAD |
| Discussion Leader: Kenneth N. Raymond (Univ. of California, Berkeley) |
| 9:00 am - 9:20 am | Introductory comments, Discussion Leader. |
| 9:20 am - 9:50 am | Nancy Olivieri (University of Toronto)
"The Continuing Search for an Effective Alternative to Deferoxamine" |
| 10:00 am - 10:15 am | Coffee Break / Photo |
| 10:15 am - 10:45 am | Raymond Bergeron (University of Florida)
"Design, Synthesis and Testing of Therapeutic Metal Chelators" |
| 10:55 am - 11:25 am | Elliott Vichinsky (Children's Hospital, Oakland)
"Emerging Problems of Iron in Sickle Cell Disease" |
| 11:35 am - 12:15 pm | Two iron chelation poster talks and open discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | INORGANIC MATERIALS IN MEDICINE |
| Discussion Leader: Michael J. Abrams (AnorMED) |
| 7:30 pm - 7:40 pm | Introductory remarks, Discussion Leader |
| 7:40 pm - 8:10 pm | Ed Shors (Interpore)
"Bone Regeneration Using Porous Ceramics: Applying the Triad" |
| 8:20 pm - 8:50 pm | Kirk Bundy (Tulane University)
"Corrosion of Metallic Biomaterials: Measurements and Consequences" |
| 9:00 pm - 9:30 pm | Jack Kleinman (Medical College of Wisconsin)
"Biomineralization in the Kidney: the Kidney Stone Problem" |
| 9:30 pm | Poster Session |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METAL ION HOMEOSTASIS IN NEURODEGENERATIVE DISEASE |
| Discussion Leader: Susan Doctrow (Eukarion) |
| 9:00 am - 9:20 am | Introductory comments, Discussion Leader |
| 9:20 am - 9:50 am | Tracey Rouault (NIH)
"Iron Regulatory Mechanisms and Neurodegenerative Disease" |
| 10:00 am - 10:30 am | Michel Baudry (University of Southern California)
"Neurotoxicity Mediated by Iron- or Zinc-induced Oxidative Stress" |
| 10:40 am - 10:55 am | Coffee Break |
| 10:55 am - 11:25 am | P. John Hart (University of Texas Health Sciences Center)
"Misfolded Copper-Zinc Superoxide Dismutase and Motor Neuron
Disease" |
| 11:35 am - 12:05 pm | Ashley Bush (Massachusetts General Hospital / Harvard Medical School)
"Metals as Therapeutic Targets in Alzheimer's Disease" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THERAPEUTIC RADIOPHARMACEUTICALS |
| Discussion Leader: Silvia S. Jurisson (University of Missouri, Columbia) |
| 7:30 pm - 7:40 pm | Introductory remarks, Discussion Leader |
| 7:40 pm - 8:10 pm | Carolyn J. Anderson (Washington University, St. Louis)
"Cu-64 Radiopharmaceuticals for Cancer Therapy" |
| 8:20 pm - 8:50 pm | Martin Brechbiel (NCI-NIH)
"Biomedical Applications of Chelation Chemistry: Chelating Agents for Radioimmunotherapy Applications" |
| 9:00 pm - 9:30 pm | Helmut Maecke (University Hospital, Basel)
"New Developments in Targeted Radiotherapy with Radiometals:
Vectors, Coordination Chemistry, Pharmacology and Clinical Data" |
| 9:30 pm | Poster Session |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ONCOLOGICAL CHEMOTHERAPY: NOVEL TARGETS AND NOVEL MECHANISMS |
| Discussion Leader: Susan Berners-Price (University of Western Australia) |
| 9:00 am - 9:20 am | Introductory comments, Discussion Leader |
| 9:20 am - 9:50 am | Nick Farrell (Virginia Commonwealth University)
"Platinum and Targeted Biomolecules" |
| 10:00 am - 10:30 am | Bernhard Lippert (University of Dortmund)
"Metal-containing Molecular Squares and Their Interactions with DNA
Targets" |
| 10:40 am - 10:55 am | Coffee Break |
| 10:55 am - 11:25 am | George Brewer (University of Michigan)
"Tetrathiomolybdate, a Copper Lowering Drug, has Cytokine Inhibiting
Effects Useful for the Treatment of Cancer and Diseases of Inflammation
and Fibrosis" |
| 11:35 am - 12:05 pm | Lawrence H. Boise (University of Miami School of Medicine)
"Arsenic Trioxide for the Treatment of Cancer" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SYNTHETIC METALLONUCLEASES FOR THE HYDROLYTIC CLEAVAGE OF RNA AND DNA: TOWARD THERAPEUTIC APPLICATIONS |
| Discussion Leader: Janet Morrow (University at Buffalo SUNY) |
| 7:30 pm - 7:40 pm | Introductory remarks, Discussion Leader |
| 7:40 pm - 8:10 pm | Robert Haener (University of Berne)
"Selective Cleavage of mRNA Using Oligonucleotide-lanthanide
Conjugates" |
| 8:20 pm - 8:50 pm | Sonya Franklin (University of Iowa)
"Peptide Based Metallonucleases: Targeted DNA Cleavage by Design" |
| 9:00 pm - 9:30 pm | Nicholas Williams (University of Sheffield)
"Metal Ion Catalysed Phosphate Ester Hydrolysis: Using Multiple
Interactions Effectively" |
| 9:30 pm | Poster Session |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TARGETTED MOLECULAR IMAGING |
| Discussion Leader: A. Dean Sherry (Univ. of Texas, Dallas) |
| 9:00 am - 9:20 am | Introductory comments, Discussion Leader |
| 9:20 am - 9:50 am | Melpomeni Fani (National Center for Scientific Research, Greece)
"Labeled Biomolecules with Diagnostic and Therapeutic Radiometals" |
| 10:00 am - 10:30 am | John V. Frangioni (Beth Israel Deaconess Medical Center, Boston)
"Small Molecule Contrast Agents for Radioscintigraphy and MRI"" |
| 10:40 am - 10:55 am | Coffee Break |
| 10:55 am - 11:25 am | Anna Moore (Massachusetts General Hospital, Boston)
"Targeted Iron Oxides in Molecular Imaging of Diabetes" |
| 11:35 am - 12:05 pm | Gregory Lanza (Washington University School of Medicine)
"Metals Mettle in Medical Molecular Imaging" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | VICE-CHAIRS' SESSION |
| Discussion Leaders: Peter Caravan (EPIX Medical)
Peter J. Sadler (University of Edinburgh) |
| 7:30 pm - 8:45 pm | Hot Topics picked by the chair and vice-chairs |
| 8:50 pm - 9:20 pm | Richard Miller (Pharmacyclics)
"Pedal to the Metal: The Development of Motexafin Gadolinium, a Novel Drug to Treat Cancer" |
| 9:30 pm | Closing Poster Session / Party |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
