SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
5:30 pm | Welcome Reception |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | CHAIRS' SESSION: METALS IN MEDICINE IN PERSPECTIVE |
| Discussion Leaders: Sonya J. Franklin (Monsanto Co.) and Jeffrey M. Zaleski (Indiana University) |
7:45 pm - 8:15 pm | Christopher P. Austin (NIH, NHGRI)
"Global Perspectives on Health, and the Role of Metallopharmaceuticals" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Mauro Ferrari (University of Texas Health Science Center) "Biomedical Nanotechnology" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm | Chairs' Reception / Poster Session A |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | GLOBAL OPPORTUNITIES FOR METALS IN MEDICINE: PART I |
| Discussion Leader: Debbie C. Crans (Colorado State University) |
9:00 am - 9:30 am | Stephen J. Lippard (Massachusetts Institute of Technology)
"Oncology" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Tom O'Halloran (Northwestern University)
"Metal Homeostasis and Oncology" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Kenneth N. Raymond (University of California, Berkeley)
"Diagnostics and Imaging" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Hilary Godwin (University of California, Los Angeles)
"High Throughput Screening for Surveillance of Infectious Diseases: Opportunities for Synergism with Metals in Medicine" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GLOBAL OPPORTUNITIES FOR METALS IN MEDICINE: PART II |
| Discussion Leader: J. Reedijk (Jan) (Leiden Institute of Chemistry) |
7:30 pm - 8:00 pm | Ashley I. Bush (The Mental Health Research Institute - Australia)
"Transition Metals in Alzheimer's Disease: From Bench to Clinic" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Samuel A. Wickline (School of Medicine, Washington University in St. Louis)
"New contrast agents for molecular diagnosis with magnetic resonance imaging: Applications in cancer and cardiovascular disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Julian Adams (Infinity Pharmaceuticals Inc.) "Boronic Acids as New Warheads for Proteases" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session B |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | METALS IN ONCOLOGY |
| Discussion Leader: Stephen J. Lippard (Massachusetts Institute of Technology) |
9:00 am - 9:20 am | Introductory Comments, Discussion Leader |
9:20 am - 9:45 am | Jacqueline K. Barton (California Institute of Technology)
"Bulky Metal Complexes Targeted to Mis-Matched DNA" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Seth M. Cohen (University of California, San Diego)
"Fragment-Based Drug Discovery for Metalloproteins" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:35 am | J. Reedijk (Jan) (Leiden Institute of Chemistry)
"New Approaches in Platnium-anticancer Chemistry" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Trevor W. Hambley (University of Sydney)
"The Distribution of Metal Based Anti-Cancer Agents in Solid Tumors" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | METALS IN METABOLIC DISEASE AND AGING |
| Discussion Leader: David A. Newsome (Avenue Optical Flash, LLC) |
7:30 pm - 7:45 pm | Introductory Remarks, Discussion Leader |
7:45 pm - 8:10 pm | Frederick K. Askari (University of Michigan)
"Tetrathiomolybdate in Treatment of Wilson's Disease" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Susan R. Doctrow (Proteome Systems, Inc., Therapeutics Research)
"Synthetics Superoxide Dimutase/Catalase Mimetics Suppress Degenerative and Pathological Processes Associated With Aging" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Chad A. Mirkin (Northwestern University)
"The Polyvalent Oligonucleotide Nanoparticle Conjugate Applications in Biodiagnostics & Medicine" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session C |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | METALS IN IMAGING AND DIAGNOSTICS |
| Discussion Leader: Kenneth N. Raymond (University of California, Berkeley) |
9:00 am - 9:20 am | Introductory Comments, Discussion Leader |
9:20 am - 9:45 am | Richard R. Cesati (Lantheus Medical Imaging)
"Novel Gd-based MR Agent" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Alan B. Packard (Children's Hospital, Harvard Med School)
"64Cu-labeled Monoclonal Antibodies for PET Imaging of Neuroblastoma" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:35 am | Jeff W.M. Bulte (The Johns Hopkins University School of Medicine)
"MRI Tracking of Cells Labeled With Iron Oxide Nanoparticles" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | A. Dean Sherry (University of Texas at Dallas & UT Southwestern)
"CEST and PARACEST Agents for Molecular Imaging: Gadolinium is Not the Only Lanthanide in Medicine" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | METALS IN INFECTIOUS DISEASES |
| Discussion Leader: Hilary Godwin (University of California, Los Angeles) |
7:30 pm - 7:45 pm | Introductory Remarks, Discussion Leader |
7:45 pm - 8:10 pm | Stephen Baker (Anacor Pharmaceuticals)
"AN2690, A Topical Oxaborole Antifungal For Onychomycosis" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Jay Parrish (Gilead Pharmaceuticals)
"Chelators in Virology" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Michael A. Marletta (University of California, Berkeley)
"Heme Processing in Plasmodium" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session D |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | METALS IN NEURODEGENERATIVE DISEASE |
| Discussion Leader: Ashley I. Bush (The Mental Health Research Institute - Australia) |
9:00 am - 9:20 am | Introductory Comments, Discussion Leader |
9:20 am - 9:45 am | David R. Brown (University of Bath)
"Metal Binding and Expression of Proteins Involved in Neurodegeneration" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:25 am | David R. Borchelt (SanteFe Health Alzheimer's Disease Research Center, University of Florida)
"Species Specific Differences Amyloid Peptide Sequence Modulate Amyloidogenesis in Transgenic Mice" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:35 am | John Schenck (General Electric Global Research)
"MRI of Endogenous Brain Iron in Alzheimer's and Other Neurodegenerative Diseases" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Lisa M. Miller (Brookhaven National Laboratory)
"X-ray Imaging of Metals in Alzheimer's Diseases and Scrapie" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HOT TOPICS AND EMERGING TECHNOLOGIES |
| Discussion Leader: TBA |
7:30 pm - 7:35 pm | Introductory Comments, Discussion Leader |
7:35 pm - 7:45 pm | Special Talk 1 |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:00 pm | Special Talk 2 |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:15 pm | Special Talk 3 |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Shuming Nie (Emory University) "Emerging Technologies: from Colloidal Gold to Quantum Dots" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Christopher J. Chang (University of California at Berkeley)
"Molecular Imaging Approaches to Probe Metal and Redox Biology in the Brain" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Poster Session E |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |