SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | Metallopharmaceuticals - Where We've Been and Where We're Going |
| Discussion Leaders: Alan Packard (Boston Children's Hospital/Harvard Medical School) and Michael Hannon (Birmingham University, UK) |
7:45 pm - 8:10 pm | Kenneth Raymond (UC Berkeley)
"Metallopharmaceuticals - Then and Now" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Michael J. Abrams (Tekmira Pharmaceuticals)
"Metal-Based Radiopharmaceuticals - Where We Were and Where We Are" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Seth Cohen (UC San Diego)
"The Future of Metallopharmaceuticals" |
9:20 pm - 9:30 pm | Discussion |
9:45 pm | Chair's Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Radioactive Metals for Imaging and Therapy |
| Discussion Leader: Martin Brechbiel (NCI) |
9:00 am - 9:30 am | Tobias Ritter (Harvard University)
"Late-Stage Fluorination for PET Imaging" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | William McBride (Immunomedics)
"Radiofluorination Using Aluminum-Fluoride (Al18F)" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Johannes Notni (TUM, Germany)
"Novel Ga-68 Chelators and Radiopharmaceuticals" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Roy Larsen (Nordic Nanovector AS)
"Current and Potential Medical Applications of Radionuclides from the Natural Radioactive Series" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Pharmacology of Metal-Based Drugs |
| Discussion Leader: Trevor Hambley (Sydney University, Australia) |
7:30 pm - 8:00 pm | Tom Piccariello (Synthonics, Inc.)
"Medicines with Metals: Application of Coordination Chemistry to Improve Pharmacokinetics" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Paula Jacobs (NCI)
"Getting Your Drug into Early Trials - Clearing the Regulatory Hurdles" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Des Richardson (Sydney University, Australia)
"Developing Metal Binding Ligands as Anti-Cancer Agents that Inhibit Metastasis and Overcome Tumor Drug Resistance" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Inorganic Nanoparticles in Medicine |
| Discussion Leader: James Dabrowiak (Syracuse University) |
9:00 am - 9:30 am | Wenbin Lin (University of Chicago)
"Nanoscale Metal-Organic Frameworks for Biomedical Imaging and Cancer Therapy" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jeffrey Zink (UCLA)
"Mesoporous Silica Nanoparticles as Drug Delivery and Diagnostic Agents" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Mostafa El-Sayed (Georgia Institute of Technology)
"Photothermal Effects of Gold Nanoparticles for Therapeutic Applications" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Clemens Burda (Case Western Reserve University)
"Photodynamic Therapy of Cancers Delivered with Gold Nanoparticles"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nanoformulations |
7:30 pm - 7:40 pm | Discussion Leader: Debbie Crans (Colorado State University)
"Introductory Remarks" |
7:40 pm - 8:05 pm | Robert G. Strickley (Gilead Sciences, Inc.)
"Formulations in Drug Discovery: Considerations for Drug Design and Preclinical In-Vivo Pharmacokinetic, Efficacy and Drug Safety Studies" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Anne Vessières-Jaouen (Université Pierre et Marie Curie)
"Lipid Nanocapsules of Ferrocenyl Complexes: The Key for Their In Vivo Anticancer Activity" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Melissa Reynolds (Colorado State University)
"Applications of Cu- and Fe-Based MOF Systems in Drug Delivery" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Contrasting the Contrasts: Metal-Based Probes for CT and MR Imaging |
9:00 am - 9:10 am | Discussion Leader: Peter Caravan (MGH/Harvard Medical School)
"Introductory Remarks" |
9:10 am - 9:35 am | David Cormode (UPenn)
"Assemblies of Inorganic Nanocrystals as Multifunctional Contrast Agents for MRI and (Multi-Color) CT" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Dean Sherry (UT Southwestern Medical Center)
"MR Agents for Imaging Physiology and Metabolism" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Kazuya Kikuchi (Osaka University)
"Development of Highly Sensitive 19F MRI Probes with Tunable Chemical Switches" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Marinella Mazzanti (Grenoble)
"From Molecular to Nanosized Lanthanide-Based Luminescent and/or Magnetic Tags" |
12:05 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Fluorescent Metalloimaging Agents |
| Discussion Leader: Nils Metzler-Nolte (Ruhr University, Germany) |
7:30 pm - 8:00 pm | Kenneth Kam-Wing Lo (City University of Hong Kong)
"Modification of Phosphorescent Rhenium(I) and Iridium(III) Polypyridine Complexes as Cellular Probes and Bioimaging Reagents" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Fijs van Leeuwen (Leiden University Medical Center)
"Hybrid Imaging Agents for Interventional Molecular Imaging" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Tia Keyes (Dublin City University)
"Peptide Targetted Metal Polypyridyl Complexes for Multi-Modal in Cell Sensing & Imaging" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Non-Canonical DNA/RNA Recognition |
| Discussion Leader: Claudia Turro (Ohio State University) |
9:00 am - 9:30 am | Jacqueline Barton (CalTech)
"Metals, Mismatches, and a New Target in DNA Repair" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Janet Morrow (SUNY Buffalo)
"Metal Activated Binding to Non-Canonical DNA Structures: Towards Optical and Conformational Switching" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | James Cowan (Ohio State University)
"Catalytic Metallodrugs Targeting Structured Viral RNA Motifs" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Marie-Paule Teulade-Fichou (CNRS)
"Targeting Quadruplex DNA with Platinum and Palladium Complexes" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Frontiers: Early Career Investigators Selected from Abstracts |
| Discussion Leader: Katherine Franz (Duke University) |
7:30 pm - 7:45 pm | Edith (Phoebe) Glazer (University of Kentucky)
"Using Light to Facilitate the Discovery of Anti-Cancer Agents"
|
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Jeremy Kodanko (Wayne State University)
"Development of Ruthenium Complexes as Photocaging Groups" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Angela Casini (University of Groningen)
"Aquaporins as Targets for Gold-Based Compounds: New Opportunities in Drug Development and Chemical Biology" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Stephen J. Lippard (MIT)
"Novel Platinum Constructs for Cancer Treatment" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |