Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Inorganic Nanomaterials in Medicine
Discussion Leader: Chad Mirkin (Northwestern University, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Patricia Horcajada (IMDEA Energy Institute, Spain)
"Engineered-Surface Metal-Organic Frameworks as Drug Nanocarriers"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Vincent Rotello (University of Massachusetts Amherst, USA)
"Bioorthogonal Catalysis Using Nanoparticle-Embedded Transition Metal Catalysts for Therapeutics and Diagnostics"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Michael Sailor (University of California, San Diego, USA)
"Autophagic Silicon Nanoparticles for Targeted Delivery of Therapeutics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metal Homeostasis in Health and Disease
Discussion Leader: Christoph Fahrni (Georgia Institute of Technology, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Alexander M. Cruickshank Lecture: Chuan He (University of Chicago, USA)
"Inhibiting Metal-Mediated Demethylation to Reshape Cancer Epigenetics"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Anne-Kathrin Duhme-Klair (University of York, United Kingdom)
"Siderophores and Their Potential Applications as Antimicrobials"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Debbie Crans (Colorado State University, USA)
"Potentiation of Oncolytic Virotherapy by Vanadium Compounds"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Raphaël Rodriguez (Institut Curie, France)
"Reprogramming the Chemical Reactivity of Metals in Cancer"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Katherine Franz (Duke University , USA) and Angela Casini (Cardiff University, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
From Chemistry to Clinic
Discussion Leader: Jonathan Sessler (University of Texas at Austin, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Chad Mirkin (Northwestern University, USA)
"Ushering in the Digital Drug Design Revolution with Spherical Nucleic Acid Nanoparticle Conjugates"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
David Puerta (Forge Therapeutics, USA)
"Forge Therapeutics: Bioinorganic Directed Drug Discovery"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Christine Brennan (MRL Ventures Fund, USA)
"From Discovery to Company Formation: Views from a Venture Capital Investor"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Recent Developments in Metallodrugs
Discussion Leader: Maria Contel (Brooklyn College, the Graduate Center, CUNY, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Jonathan Sessler (University of Texas at Austin, USA)
"Gadolium Texaphyrins, Platinum and Gold"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Valentina Gandin (University of Padova, Italy)
"Copper Complexes as Anticancer Agents: New Mechanistic Insights"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
James McKerrow (University of California, San Diego, USA)
"A Metal-Containing Drug Repurposed for Neglected Tropical Diseases"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Celine Marmion (Royal College of Surgeons in Ireland, Ireland)
"Innovative Metallo-Prodrug Strategies Leading to Multimodal Cancer Therapeutics"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metalloglycomics
Discussion Leader: Susan Berners-Price (Griffith University, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Katelyn Arnold (Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA)
"Using Synthetic Heparan Sulfate to Treat Acute Liver Injury"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Mauro Pavao (Federal University of Rio de Janeiro, Brazil)
"Manganese and Glycosaminoglycans in Tumor Progression: From Cell Migration to Premetastatic Niche Formation"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Nicholas Farrell (Virginia Commonwealth University, USA)
"Glycans as Ligands in Bioinorganic Chemistry. Chemical and Biological Studies in Metalloglycomics"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Agents for Imaging Applications
Discussion Leader: David Giedroc (Indiana University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Roger Alberto (University of Zurich, Switzerland)
"Technetium and Rhenium Complexes with Aromatic Hydrocarbons as π-Ligands: An Entry into Biomimetic Imaging"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Carolyn Anderson (University of Pittsburgh, USA)
"How Chelator Choice Impacts Biodistribution of Radiometal-Labeled Biomolecules"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Jun-Long Zhang (Peking University, China)
"From Cell Imaging to Predrug: The Renaissance of Metallosalens in Biological Applications"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Bengang Xing (Nanyang Technological University, Singapore)
"Cutting Edge Fluorescence Imaging Strategies for Precise Regulation of Cellular Functions and Localized Theranostics"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Case Studies in Translational Research
Discussion Leader: Nicholas Farrell (Virginia Commonwealth University, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Walter Berger (Medical University of Vienna, Austria)
"Once upon a Time in Vienna: A Story from Ruthenium to Platinum"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Christian Kowol (University of Vienna, Austria)
"Once upon a Time in Vienna: The Power of Activation by Reduction"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Petra Heffeter (Medical University of Vienna, Austria)
"Once upon a Time in Vienna: Tumor-Specific Accumulation of Metallodrugs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Analytical Techniques for Metals in Biological Systems
Discussion Leader: Christian Hartinger (University of Auckland, New Zealand)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Victoria DeRose (University of Oregon, USA)
"Methods for Comprehensive Analysis of Platinum Targets in Yeast and Mammalian Cancer Cells"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
Peter Lay (The University of Sydney, Australia)
"Metal Speciation in In Vitro and In Vivo Biological Activities from Drugs to Toxins"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Ryszard Lobinski (CNRS, France)
"Global Approaches to Metal Speciation: Metallomics"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Samuel Meier-Menches (University of Vienna, Austria)
"Emerging Proteomics Methods to Elucidate Metallodrugs' Mechanisms of Action in the Cellular Context"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Young Investigator Presentations
Discussion Leader: Angela Casini (Cardiff University, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Loi Do (University of Houston, USA)
"Therapeutic SIMCats: In Pursuit of Catalytic Medicines"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Bo Li (University of North Carolina at Chapel Hill, USA)
"Metal-Chelating Antibiotics and Natural Products"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Anthony Grillo (University of Washington Medicine, USA)
"A Small Molecule that Transports Iron Promotes Iron Absorption and Hemoglobinization"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Justin Wilson (Cornell University, USA)
"Rhenium(I) Complexes as Anticancer Agents: Challenges and Opportunities"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure