Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Supramolecular Metal-Based Molecules for Biomedical Applications
Discussion Leader: Michael Hannon (University of Birmingham, United Kingdom)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Wenbin Lin (University of Chicago, United States)
"Nanoscale Coordination Polymers for Cancer Therapy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Michael Hannon (University of Birmingham, United Kingdom)
"Metallo-Supramolecular Cylinders Bind SARS-CoV-2 Regulatory RNA and Prevent Viral Replication"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Janet Morrow (University at Buffalo, SUNY, United States)
"Metal Organic Polyhedra for Murine Tumor Imaging and Drug Delivery"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Clinical Advances for Metals in Medicine
Discussion Leader: Walter Berger (Medical University of Vienna, Austria)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Sherri McFarland (The University of Texas at Arlington, United States)
"Clinical Update on TLD1433, a Metallodrug Photosensitizer for Treating Non-Muscle Invasive Bladder Cancer with Photodynamic Therapy"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Thomas Meade (Northwestern University, United States)
"Real-Time Tracking of Gene Therapy with Bioactivated MR Contrast Probes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Linda Vahdat (Dartmouth Hitchcock Medical Center, United States)
"Copper Depletion as a Therapeutic Strategy in Breast Cancer"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
General Discussion
11:45 am - 12:05 pm
Adam Carie (Bold Therapeutics, Canada)
"Clinical and Translational Updates for BOLD-100: a Ruthenium-based Compound Studied in Combination with FOLFOX Chemotherapy in Phase 1b for Patients with Advanced GI Solid Tumors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Maria Contel (Brooklyn College and CUNY, United States) and Jason Lewis (Memorial Sloan Kettering Cancer Center, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis in Cells
Discussion Leaders: Luca Salassa (Donostia International Physics Center, Spain) and Loi Do (University of Houston Chemistry Department, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
José Luis Mascareñas (Universidade de Santiago de Compostela, Spain)
"Biocompatible Transformations Involving Organometallic Catalysis "
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Siavash Kurdistani (UCLA, United States)
"Mechanism of Copper Reduction by Histone H3"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Stefano Fedeli (University of Massachusetts Amherst - Department of Chemistry, United States)
"Bioorthogonal Nanozymes for Localized Cancer Imaging and Therapy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Denise Lovison (Technische Universität München (TUM), Germany)
"Catalysis in Cells with Water-soluble Ru(II) Complexes as Efficient Catalysts for Transfer Hydrogenation Reactions Involving the NAD+/NADH Couple"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Metallomics Methods and Tools
Discussion Leaders: Samuel Meier-Menches (University of Vienna, Austria) and Dinorah Gambino (Facultad de Química, Universidad de la República, Uruguay, Uruguay)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Rachela Popovtzer (Bar-Ilan University, Israel)
"Seeing is Believing: Tracking the Movement of Cells Within Our Body"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Eric Gale (MGH/ Harvard Medical School, United States)
"Iron Complexes for Precision Magnetic Resonance Imaging of Reactive Oxygen Species"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Sarah Michel (University of Maryland, United States)
"How to Find a Needle in a Haystack: Tracking Iron Nanoparticles in Clinical Samples"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Sharon Ruthstein (Bar Ilan University, Israel)
"Deciphering the Cellular Copper Trafficking Mechanism to Develop a New Generation of Copper-Based Biomarkers"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Valeria Culotta (Johns Hopkins University, United States)
"Metals and Reactive Oxygen Species: Tales of a Successful Fungal Pathogen"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leaders: Carolyn Anderson (University of Missouri, United States) and Anne-Kathrin Duhme-Klair (University of York, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Camilla Abbehausen (University of Campinas, Brazil)
"Metal-Based Compounds for Targeted Chemotherapy Against Leishmaniasis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Cinzia Imberti (University of Warwick, United Kingdom)
"Untangling the Link Between Cisplatin and Copper Trafficking in Vivo with Radionuclide Imaging"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Jessie Nedrow (University of Pittsburgh, United States)
"Preliminary Evaluation of Alpha-emitting Radioembolization in Animal Models of Hepatocellular Carcinoma"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Maria Jesus Moran Plata (Donostia International Physics Center (DIPC), Spain)
"Biocompatible Hydogels for Platinum-based Chemotherapy"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Chelation Strategies and Applications for Radionuclides and Contrast Agents
Discussion Leaders: Eric Gale (MGH/ Harvard Medical School, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Rebecca Abergel (University of California, Berkeley, United States)
"Targeted Radionuclide Therapy: The Promise of Short-Lived Alpha-Emitting Actinides"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Peter Caravan (Massachusetts General Hospital, Harvard University, United States)
"Molecular MR and PET Probes for Detecting and Staging Tissue Fibrosis and Measuring Treatment Response"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Jason Lewis (Memorial Sloan Kettering Cancer Center, United States)
"Zirconium-89-based Biomolecular Imaging Agents"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Darren Magda (Lumiphore, Inc., United States)
"Macrocyclic 1,2-HOPO Bifunctional Chelators for Commercial Time-Resolved Eu(III) Luminescence Assays and Radiopharmaceutical Applications"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Katherine Vallis (University of Oxford, United Kingdom)
"Radionuclides, Ruthenium and Radiosensitisation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Essential Metals in Disease Mechanisms
Discussion Leader: Katherine Franz (Duke University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Donita Brady (University of Pennsylvania, United States)
"Copper Conducted Kinase Signal Transduction: A Novel Vulnerability in Cancer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Martin Burke (University of Illinois at Urbana-Champaign, United States)
"Molecular Prosthetics for Missing Metal Transporters"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Matteo Ceccarelli (University of Cagliari, Italy)
"Rationalizing the Transport of Trojan Horse Compounds for Crossing the Outer Membrane of Gram-Negative Bacteria"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stimuli-Responsive Materials for Therapy and Imaging
Discussion Leader: Justin Wilson (Cornell University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Anna Cristina Samia (Case Western Reserve University, United States)
"Hydrogel Nanocomposites Designed for the Treatment of Prosthetic Joint Infections"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Alexander Spokoyny (University of California, Los Angeles, United States)
"Hybrid Multivalent Protein Binders Assembled from Boron Clusters"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Janet Morrow (University at Buffalo, SUNY, United States)
"Metal Organic Polyhedra for Murine Tumor Imaging and Drug Delivery"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Gilles Gasser (Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, France)
"Towards Specific Delivery and Controlled Release of Metal Complexes in Tumours"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Darren Griffith (Royal College of Surgeons in Ireland, Ireland)
"Tumour Targeting of an Oxaliplatin-based Chemotherapeutic Regimen using Ultrasound Targeted Microbubble Destruction"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Targeted Metal-Based Therapeutics
Discussion Leader: Thomas Meade (Northwestern University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Seth Cohen (UC San Diego, United States)
"Metallofragments as 3-Dimensional Scaffolds for Fragment-Based Antiviral Drug Discovery"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Maria Contel (Brooklyn College and CUNY, United States)
"Biodegradable Nanocarriers and Antibodies as Targeting Delivery Vehicles for Gold-based Anticancer Agents"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Dmytro Havrylyuk (University of Kentucky, United States)
"Ru-PROTACs are a Promising Tool for the Photocontrol of Protein Degradation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Adoracion Gómez Quiroga (Universidad Autonoma de Madrid, Spain)
"Solvent and Buffer Ion Roles in Metallodrug Mechanism: Spectators, Carriers or Noise?"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure