Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Bacterial Nanomachines
Discussion Leader: John Mekalanos (Harvard Medical School, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Marek Basler (University of Basel, Switzerland)
"Type VI Secretion System: Structure and Function"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Melanie Blokesch (Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland)
"The Interplay Between Two Nanomachines Drives Horizontal Gene Transfer in Vibrio cholerae Communities"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Gabriel Waksman (University College London / Birkbeck, University of London, United Kingdom)
"Type IV Secretion Systems"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bacterial Effectors and Toxins
Discussion Leader: Craig Roy (Yale School of Medicine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Elizabeth Hartland (University of Melbourne, Australia)
"EHEC/EPEC Effectors"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Denise Monack (Stanford University, USA)
"Salmonella Effector Loss Accelerates Pathogen Dissemination Through Gut Lymphatics"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
John Whitney (McMaster University, Canada)
"A Broadly Distributed Toxin Family Mediates Contact-Dependent Antagonism Between Gram-Positive Bacteria"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Gleb Pishchany (Harvard Medical School, USA)
"Amycomicin: An Antibiotic that Isn't"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Jorge Galan (Yale School of Medicine, USA)
"Salmonella typhi Toxins"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Complex Microbial Communities and Intracommunity Interactions
Discussion Leader: Laurie Comstock (Harvard Medical School, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Matthew Parsek (University of Washington, USA)
"Pseudomonas aeruginosa : Hedging Its Bets on a Surface"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Raphael Valdivia (Duke University, USA)
"Genetics for the Microbiota"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Andrew Goodman (Yale University, USA)
"Causes and Consequences of Microbiome Variation"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cell Surface Structures and Adhesins
Discussion Leader: Petra Dersch (Helmholtz Center for Infection Research, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Olaf Schneewind (University of Chicago, USA)
"Bacillus anthracis Invasion of the Gastrointestinal Tract"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Scott Hultgren (Washington University in St. Louis, USA)
"Phenotypic Diversity of Urinary Tract Infections"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Manuela Hospenthal (Institute of Structural and Molecular Biology (ISMB), United Kingdom)
"The Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
Corey Stevens (Queen's University, Canada)
"Stuck in the Middle with You: Characterizing the Association Between Two Antarctic Microorganisms"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Lotte Sogaard-Andersen (Max Planck Institute for Terrestrial Microbiology, Germany)
"Type IV Pilus Structure"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Stephen Trent (University of Georgia, USA)
"LPS Modification/PG Interactions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolite Signaling and Response by Host and Pathogen
Discussion Leader: Renee Tsolis (University of California, Davis, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Alexis Kaushansky (Center for Infectious Disease Research, USA)
"The Battle Between Intracellular Pathogens and Their Hosts: Common Threads and Unique Features"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Michael Sigal (Max Planck Institute for Infection Biology, Germany)
"Interactions of Helicobacter pylori with Gastric Stem Cell Signaling"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Brian Ho (Harvard Medical School, USA)
"Tracking Bacterial Population Dynamics During Vibrio cholerae Infection Through Contact-Dependent Inter-Bacterial Interactions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Sebastian Winter (University of Texas Southwestern Medical Center, USA)
"Metabolic Sensing/Manipulation by Enteric Bacteria"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Methods and Applications
Discussion Leader: Michael Gilmore (Harvard Medical School, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Joerg Vogel (University of Wuerzburg, Germany)
"Simultaneous Phenotyping of Host and Pathogen"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Steven Projan (MedImmune / Astrazeneca, USA)
"Antibody Targeting of Bacterial Surface Features"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Seemay Chou (University of California, San Francisco, USA)
"The Bacterial Cell Wall: Probing an Ancient Structure with Next Generation Tools"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Jason Rosch (St. Jude Children's Research Hospital, USA)
"Modeling Pneumococcal Transmission Dynamics in Ferrets"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Man-Wah Tan (Genentech, USA)
"Engineering the Immune System to Treat Life-Threatening Bacterial Infections"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Interface Between Microbes and the Immune System
Discussion Leader: Denise Monack (Stanford University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Anne Muller (University of Zurich, Switzerland)
"H. pylori Modulation of Systemic Immunity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Victor Torres (New York University School of Medicine, USA)
"The Many Faces of the Staphylococcus aureus Leukocidins"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Elaine Tuomanen (St. Jude Children's Research Hospital, USA)
"Expanding Bacterial Signaling Vocabulary from Inflammation to Neuroproliferation and Brain Repair"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterogeneity in Niches and Phenotypes
Discussion Leader: Joan Mecsas (Tufts University School of Medicine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Wolf-Dietrich Hardt (ETH Zurich, Switzerland)
"Population Heterogeneity During Salmonella Infection"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Sophie Helaine (Imperial College London, United Kingdom)
"Salmonella Persistence"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Keara Lane (Stanford University, USA)
"Single-Cell Analysis Reveals Dynamic Patterns of TLR Signaling Associated with Distinct Stages of Salmonella Infection"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
Shumin Tan (Tufts University School of Medicine, USA)
"Life on the Inside: Illuminating Microenvironment Heterogeneity During Mycobacterium tuberculosis Infection"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Kenn Gerdes (University of Copenhagen, Denmark)
"Bacterial Multidrug Tolerance, Magic Spot and Toxin-Antitoxins"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Ralph Isberg (Tufts University School of Medicine / Howard Hughes Medical Institute, USA)
"Bacterial and Host Signals that Create Niche Heterogeneity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Host-Pathogen Crosstalk
Discussion Leader: Xavier Nassif (Institut Necker-Enfants Malades, France)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Lalita Ramakrishnan (University of Cambridge, United Kingdom)
"Host-Pathogen Cross-Talk During Mycobacteria Infection"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Matthew McCallum (University of Toronto, Canada)
"The Molecular Mechanism of the Type IVa Pilus Motor"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Sumitra Mitra (Nanyang Technological University, Singapore)
"Sortase A: Towards Understanding Protein Localization-Function Relationship"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Philippe Sansonetti (Institut Pasteur, France)
"Beneficial and Destructive Microbiota-Host Interaction"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure