Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Features of the Bacterial Cell Envelope
Discussion Leader: Stephen Trent (University of Georgia, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
Sigal Ben-Yehuda (The Hebrew University of Jerusalem, Israel)
"Bacterial Nanotubes: Conduits for Intra- and Inter-Kingdom Molecular Trafficking"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Andreas Peschel (University of Tübingen, Germany)
"Staphylococci Remodel Surface Glycopolmers to Shift from Commensal to Pathogen Behavior and Evade Immunity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Nina Salama (Fred Hutchinson Cancer Research Center, USA)
"Phenotypic Adaptations to Life in the Stomach"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bacterial Biofilms and Adhesins
Discussion Leader: Melanie Blokesch (Swiss Federal Institute of Technology Lausanne, Switzerland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Jean-Marc Ghigo (Institut Pasteur, France)
"Adhering Under Pressure: Exploring Escherichia coli Biofilm Formation Through Experimental Evolution"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Xavier Nassif (Institut Necker-Enfants Malades, France)
"Type IV Pilus Interaction of Meningococci with Microvessels: A Sugar Story"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
David Adams (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
"DNA-Uptake Pili of Vibrio cholerae : One Pilus, Three Fundamental Functions"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Fitnat Yildiz (University of California, Santa Cruz, USA)
"Mechanisms and Consequences of Biofilm Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Cagla Tukel (Lewis Katz School of Medicine, Temple University, USA)
"Bacterial Amyloid Curli: Expression, Immune Recognition and Pathogenicity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Aaron Whiteley (Harvard Medical School, USA)
"Bacterial cGAS-Like Enzymes at the Host-Pathogen Interface"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Renee Tsolis (University of California, Davis, USA) and Petra Dersch (University of Münster, Germany)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modulation of Host Signaling by Pathogens
Discussion Leader: Joanne Engel (University of California, San Francisco, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Pascale Cossart (Institut Pasteur, France)
"Microbiota and Bacterial Infections: The Listeria Paradigm"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Christoph Dehio (Biozentrum, University of Basel, Switzerland)
"Bartonella Effectors Targeting Innate Immune Signaling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Jean Celli (Paul G. Allen School for Global Animal Health, Washington State University, USA)
"Modulation of Golgi Functions by Brucella Type IV Effectors"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Matthias Machner (National Institutes of Health, USA)
"Large Impact of Small GTPases During Legionella Infection"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Microbial Communities in the Host: Interactions Between Hosts and Their Microbes
Discussion Leader: Raphael Valdivia (Duke University, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Michael Fischbach (Stanford University, USA)
"Small Molecules from the Human Microbiota"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Mathias Hornef (RWTH Aachen University, Germany)
"The Host-Microbe Interaction in the Neonate Intestine"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Ilana Kolodkin-Gal (Weizmann Institute of Science, Israel)
"Intracellular Calcium Carbonate Drives Biofilm Formation and Persistent Infections"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Eric Pamer (Memorial Sloan-Kettering Cancer Center, USA)
"Mechanisms of Microbiota-Mediated Suppression of Antibiotic-Resistant Bacterial Pathogens"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Bärbel Stecher (Ludwig Maximilian University of Munich, Germany)
"The Microbiota Provides Multiple Insurance Against Salmonella Infections"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Marteyn Benoit (Institut Pasteur, France)
"Enteropathogen-Mediated Oxygen Depletion Is Essential for Intestinal Mucosa Colonization"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Mariana Byndloss (Vanderbilt University Medical Center, USA)
"Increased Epithelial Oxygenation Links High-Fat Diet to Dysbiosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genomic and Evolutionary Approaches to Studying Microbes
Discussion Leader: Stephen Diggle (Georgia Institute of Technology, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Robert Kingsley (Quadram Institute Bioscience, United Kingdom)
"Population Genetics of Salmonella typhimurium Reveals Anthropogenic Selection and Niche Adaptation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Caroline Taouk (Yale University, USA)
"Exploring Microbiome-Host Interactions at the Single-Cell and Single-Gene Level"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ruth Massey (University of Bristol, United Kingdom)
"Using Population Genomics to Define the Pathogenicity of Bacterial Pathogens"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Alexandra Koumoutsi (EMBL Heidelberg, Germany)
"Interkingdom Interactions Between Candida albicans and Escherichia coli "
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Lauren Davey (Duke University, USA)
"A Genetic Dissection of Mucin Utilization and Host Colonization by the Beneficial Gut Microbe Akkermansia muciniphila "
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innate Immunity During Bacterial Infection
Discussion Leader: Andreas Baumler (University of California, Davis, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Igor Brodsky (University of Pennsylvania, USA)
"The Role of Inflammatory and 'Non-Inflammatory' Death Pathways in Control of Bacterial Infection"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Max Gutierrez (The Francis Crick Institute, United Kingdom)
"Interactions Between Mycobacterium tuberculosis and Macrophages in Time and Space"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Bennett Penn (University of California, Davis, USA)
"A Mycobacterium tuberculosis -Human Protein-Protein Interaction Map Identifies a Switch Between Host Antiviral and Antibacterial Responses"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Vladimir Diaz-Ochoa (University of California, Davis, USA)
"NRAMP1 Contributes to Neutrophil Bactericidal Function"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Manuela Raffatellu (University of California, San Diego, USA)
"New Insights on the Mucosal Response to Salmonella "
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Denise Monack (Stanford University, USA)
"TNF Limits Pathogen-Driven Polarization of Alternatively Activated (M2) Granuloma Macrophages to Restrict Salmonella During Persistent Infection"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Francisco Garcia-Del Portillo (Centro Nacional de Biotecnologia (CNB), CSIC, Spain)
"The Peptidoglycan in Intracellular Salmonella : Impact on Host Defences"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Secretion Systems and Toxins
Discussion Leader: Francisco Garcia-Del Portillo (Centro Nacional de Biotecnologia (CNB), CSIC, Spain)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Tracy Palmer (Newcastle University, United Kingdom)
"The Staphylococcus Type VII Secretion System and Intra-Species Competition"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Alain Filloux (Imperial College London, United Kingdom)
"The Type VI Secretion System (T6SS): A Bacterial Killing Machine"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Craig Roy (Yale School of Medicine, USA)
"Inhibition of Host Pathogen Sensing Pathways by Coxiella burnetii "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Fabian Rivera-Chávez (Harvard Medical School, USA)
"Cholera Toxin Promotes Pathogen Acquisition of Host-Derived Nutrients"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Yael Litvak (University of California, Davis, USA)
"Shiga Toxin-Mediated Pathogen Expansion"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bacterial Virulence Networks
Discussion Leader: Ilan Rosenshine (The Hebrew University of Jerusalem, Israel)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Carmen Buchrieser (Institut Pasteur, France)
"Legionella pneumophila : Regulation of Virulence in the Bacteria and the Host"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Daniel Lopez (Spanish National Research Council (CSIC), Spain)
"Proteolytic Regulation of Bacterial Membrane Microdomains Assembly"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
John Leong (Tufts University School of Medicine, USA)
"Effects of Aging on Immunity to Streptococcus pneumoniae Infection"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Shantanu Bhatt (Saint Joseph's University, USA)
"Hfq and Hfq-Dependent Small RNAs Control Virulence in the Attaching and Effacing Pathogens, Enteropathogenic Escherichia coli and E. albertii "
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Vanessa Sperandio (University of Texas Southwestern Medical Center, USA)
"The Highs and Lows of Enteric Infections"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
William Sause (New York University School of Medicine, USA)
"The Purine Biosynthesis Regulator PurR Moonlights as a Virulence Regulator in Staphylococcus aureus "
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
John Whitney (McMaster University, Canada)
"An Unexpected Mechanism of Interbacterial Antagonism"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Wai-Leung Ng (Tufts University School of Medicine, USA)
"Cyclic GMP-AMP Signaling Pathway Interactions in Vibrio cholerae "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Methodologies for Studying Host-Microbe Interactions
Discussion Leader: Karen Ottemann (University of California, Santa Cruz, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Knut Drescher (Max Planck Institute for Terrestrial Microbiology, Germany)
"Single-Cell Analysis of Biofilms Reveals Cellular Interactions and Community Functions"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Grant Jensen (California Institute of Technology, USA)
"Structure and Function of Bacterial Secretion Systems by Electron Cryotomography of Intact Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Dennis Ko (Duke University, USA)
"The Hi-HOST Phenome Project: An Atlas of Human Genetic Variation Affecting Host-Microbe Interactions"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure