Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Bacterial Cell Surface Structures
Discussion Leader: Petra Dersch (University of Münster, Germany)
7:40 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
Sophie Helaine (Harvard Medical School, United States)
"Internal Conflicts in Persisters During Infection"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Joanne Engel (University of California, San Francisco, United States)
"Bacterial Mimicry of Viruses: how Chlamydia use SLiM Mimics to Reprogram the Host"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
M. Stephen Trent (University of Georgia, United States)
"Building the Gram-Negative Outer Membrane: Transporting Lipids to the Bacterial Surface"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Host-Microbe Interactions
Discussion Leader: Fitnat Yildiz (University of California, Santa Cruz, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Kerwyn Huang (Stanford University, United States)
"Physical Aspects of Host-Microbe Interactions"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Stavroula Hatzios (Yale University, United States)
"A Microbial Transporter of the Dietary Antioxidant Ergothioneine"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Renee Tsolis (University of California, Davis, United States)
"NRAMP1 Increases Bacteriocidal Activity of Neutrophils Against Salmonella "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Eddie Geisinger (Northeastern University, United States)
"Genome-Wide Phage Susceptibility Analysis in Acinetobacter baumannii Reveals Capsule Modulation Strategies that Determine Phage Infectivity"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
John Mekalanos (Harvard Medical School, United States)
"Programmed in vivo Gene Expression to Understand the Temporal and Spatial Aspects of Virulence and Host Responses"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Ben Koestler (Western Michigan University, United States)
"Metabolism-Mediated Signaling During Shigella Pathogenesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Karen Ottemann (University of California, Santa Cruz, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Application of Imaging and Visualization Techniques
Discussion Leader: Nina Salama (Fred Hutchinson Cancer Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Manuela Hospenthal (ETH, Zurich, Switzerland)
"Mechanisms of DNA Uptake by Naturally Competent Bacteria"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Xuhui Zheng (University of Washington, United States)
"C-di-GMP and cAMP Signaling is Selectively Activated by Different Surfaces in Pseudomonas aeruginosa "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ariane Briegel (Leiden University, The Netherlands)
"Exploring the Structure and Function of Microbial Chemotaxis by Cryo-Electron Tomography"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Carrie Shaffer (University of Kentucly, United States)
"Evolutionary Innovations in the H. pylori cag Type IV Secretion System"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Colonization, Adhesion and Host Impact
Discussion Leader: Hank Seifert (Northwestern University Feinberg School of Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Kimberly Kline (University of Geneva, Switzerland)
"Pathogenesis of Enterococcal Polymicrobial Wound Infection"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Joana Sa Pessoa Santos (Queens University Belfast, United Kingdom)
"A Trans-Kingdom T6SS Effector Induces the Fragmentation of the Mitochondrial Network and Activates Innate Immune Receptor NLRX1 to Promote Infection"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Aimee Shen (Tufts University School of Medicine, United States)
"Unique Mechanisms for Regulating Clostridioides difficile Division Events"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Jing Yan (Yale University, United States)
"Vibrio Cholerae Biofilms use Modular Adhesins with Glycan-Targeting and Nonspecific Surface Binding Domains for Colonization"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Karen Guillemin (University of Oregon, United States)
"Teaming with Microbes: Lessons from the Zebrafish Intestine"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Guy TRAN VAN NHIEU (I2BC, France)
"Vinculin Oligomerization Mediated by the Shigella Rffector IpaA during Bacterial Invasion and cell Adhesion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Delaney Miller (Indiana University, United States)
"Inside Out: How honey bee Symbiont Populations Persist Across Colony Niches"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bacteriophage and Host Defense
Discussion Leader: Wai-Leung Ng (Tufts University School of Medicine, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Alexander Harms (ETH Zürich, Switzerland)
"Always two they are: Viral Strategies to Overcome the Resilience of Antibiotic-Tolerant Bacteria"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Aude Bernheim (Institut Pasteur, France)
"Conservation of Anti-Viral Immunity Across Domains of Life"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Michele LeRoux (Washington University in St Louis, United States)
"The role of Toxin-Antitoxins in Bacterial-Phage Specificity"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Joseph Bondy-Denomy (University of California, San Francisco, United States)
"Mechanisms for Bacteriophages to Evade Anti-Phage Immunity"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Frontiers in Antimicrobials
Discussion Leader: Mario Feldman (Washington University School of Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Ana Rita Brochado (Tübingen University, Germany)
"Context-Dependent Antibiotic Activity"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Regina Baldini (Universidade de São Paulo, Brazil)
"Cold shock induces Pseudomonas aeruginosa antibiotic resistance"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Emily Balskus (Harvard University, United States)
"Deciphering Microbes and Microbiomes with Chemistry"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Zhaomin Yang (VT-Biological Science, United States)
"Discovery of Two Inhibitors of the Type IV Pilus Assembly ATPase PilB as Potential Antivirulence Compounds"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Zemer Gitai (Princeton University, United States)
"M3-Seq: A Single cell Sequencing Approach to Understanding Antibiotic Action"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Jake Colautti (McMaster University, Canada)
"Molecular Basis for Recognition of Diverse Protein Substrates by type VI Secretion Systems"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functional Microbiomes
Discussion Leader: Andreas Baumler (University of California, Davis, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Neil Surana (Duke University, United States)
"A Symbiont Regulates Immune-Mediated Diseases via a Phosphocholine-Modified Exopolysaccharide"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Karina Xavier (Instituto Gulbenkian de Ciencia, Portugal)
"Interspecies Interactions Shaping gut Microbiota Functions"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Aman Kumar (Yale University, United States)
"Understanding mechanisms of colonization resistance using non-antibiotic drugs"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Eric Martens (University of Michigan, United States)
"Bacteroides cell Surface Systems for Mucus Degradation Contribute to Mucus Erosion and Inflammation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Signal Transduction
Discussion Leader: Shumin Tan (Tufts University School of Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Petra Dersch (University of Münster, Germany)
"Shaping Yersinia Virulence for Acute and Persistent Infections"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Laura Mike (University of Toledo, United States)
"Klebsiella regulates capsule in response to human urine"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Christopher Sassetti (UMass Chan Medical School, United States)
"Cryptic Genetic Variation in M. Tuberculosis Influences Pathogenesis and Antibiotic Efficacy"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Andres Vazquez-Torres (University of Colorado School of Medicine, United States)
"The tRNA Repair System Rtc Preserves Salmonella Translation During Axidative Stress"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Erin Green (Vanderbilt University Medical Center, United States)
"Adaptor-Mediated Control of Lon-Dependent Proteolysis Influences Desiccation Tolerance in Acinetobacter baumannii "
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Urs Jenal (University of Basel, Switzerland)
"Surface Colonization of a Human Pathogen Revisited"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Intracellular Infection
Discussion Leader: Matthias Machner (National Institutes of Health, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Guillaume Dumenil (Institut Pasteur, France)
"Cryo-EM Structures of Type IV pili Complexed with Nanobodies Reveal Immune Escape Mechanisms"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Stevens Robertin (London School of Hygiene and Tropical Medicine, United Kingdom)
"Use of Staphylococcus Aureus to study Septin Interactions with Gram-Positive Bacterial Pathogens"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Heran Darwin (New York University School of Medicine, United States)
"The Aldehyde Hypothesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ralph Isberg (Tufts University School of Medicine, United States)
"Rapid Niche Formation and its Programmed Destruction During Pathogen Intracellular Growth"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure