Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Evolution and Dynamics of Organelles and Their Genomes
Discussion Leader: Andreas Weber (Heinrich Heine University Duesseldorf, Germany)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Dan Mishmar (Ben-Gurion University of the Negev, Israel)
"The Identity Crisis of the Mitochondrion - on Retaining a Bacterial Regulatory Heritage Versus Adaptation to the Host"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Dan Sloan (Colorado State University, United States)
"Mechanisms of Mutation Rate Variation and Heteroplasmic Sorting in Plant Mitochondrial and Plastid Genomes"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Jason Cournoyer (University of Illinois at Urbana-Champaign, United States)
"Experimental Endosymbiotic Models to Investigate Molecular Drivers of Chloroplast Evolution"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Pawel Mordaka (University of Cambridge, United Kingdom)
"Redesigning the Chlamydomonas reinhardtii Chloroplast Genome"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organelle Gene Expression
Discussion Leader: Antoni Barrientos (Miller School of Medicine, University of Miami, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Brendan Battersby (University of Helsinki, Finland)
"Errors in Mitochondrial Gene Expression"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Flavia Fontanesi (University of Miami, United States)
"Coordination of Mitochondrial Gene Expression with Mitoribosome Biogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Dmitry Temiakov (Thomas Jefferson University, United States)
"Mechanisms of Mitochondrial Promoter Recognition in Humans and Other Mammalian Species"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Ingrid Lafontaine (Institut de Biologie Physico Chimique, Sorbonne Université, Paris , France)
"Involvement of alpha-solenoid proteins and peptidases in gene expression and protein import in organelles: diversity and evolution"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Aaron Aker (Harvard Medical School, United States)
"Most Dual-Origin Complexes Are Regulated Asynchronously During Chloroplast Biogenesis"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Hong Weng Pang (University of Miami, United States)
"Identification and Characterization of Mitoribosome Interactome in Standard and Oxidative Conditions"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Erik McShane (Harvard Medical School, United States)
"RNA Flow Analysis Reveals How Differential Turnover, Transcription Termination and Ribosome Engagement Set Mitochondrial Transcript Levels"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
John Moran (University of Miami, United States)
"Mitochondrial mRNA Structure as a Driver of Leigh Syndrome"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Anna Wredenberg (Karolinska Institutet, Sweden)
"Angel2 Phosphatase Activity is Required for Non-Canonical Mitochondrial RNA Processing"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Liza Pon (Columbia University, United States) and Maya Schuldiner (Weizmann Institute of Science, Israel)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Import, Sorting and Assembly
Discussion Leader: Agnieszka Chacinska (IMol PAS, Poland)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Paul Jarvis (University of Oxford, United Kingdom)
"Protein Import into Chloroplasts and its Regulation by the Ubiquitin-Proteasome System"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Peter Rehling (University Medical Center Gottingen, Germany)
"Role of TIM23 in Protein Import and Sorting"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
William Zerges (Biology Department, Concordia University, Canada)
"Chloroplast-Localized Translation for Protein Targeting in Chlamydomonas"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Oliver Caspari (Institut Pasteur, Department of Microbiology, France)
"How protein import may have evolved from antimicrobial attack and defence during endosymbiosis"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Organelle Dynamics: Division, Differentiation and Contacts
Discussion Leader: Liza Pon (Columbia University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Yoshiki Nishimura (Kyoto University, Japan)
"Deciphering the Dynamism of Chloroplast Nucleoids"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Maya Schuldiner (Weizmann Institute of Science, Israel)
"Targeting Proteins to Mitochondria - the Long and Winding Road"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Samantha Lewis (University of California, Berkeley, United States)
"Mitochondrial Genome Integrity and Inheritance"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Büsra Güngör (Technical University of Kaiserslautern, Germany)
"The ER Membrane Complex (EMC) Can Functionally Replace the Oxa1 Insertase in Mitochondria"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Vanessa Valencia (Heinrich Heine University Duesseldorf, Germany)
"Interorganellar communication sites within plant cells"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Chloé Morel (University of Bordeaux, UMR5234, MFP, France)
"A Unusual Mitofusion is Involved in Mitochondrial Membranes Fusion in Trypanosoma brucei "
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Kyung Kim (Dong-A university, South Korea)
"Mitonuclear Translational Control by the Peptide in Mitochondrial Ribosomal RNA"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Jana Schuettpelz (McGill Univeristy, Canada)
"The role of SLC25A46 in mitochondrial fission and fusion through oligomerization of MFN2 and OPA1"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure and Function of Organelle Complexes
Discussion Leader: Johannes Herrmann (University of Kaiserslautern, Germany)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Rasmus Kock Flygaard (Aarhus University, Denmark)
"Structural Basis of Mitochondrial Inner Membrane Curvature"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Amandine Marechal (University College London, United Kingdom)
"Structures of Yeast Respiratory Supercomplexes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Eva Nyvltova (University of Miami Miller School of Medicine, United States)
"Coordination of Metal Center Biogenesis in Human Cytochrome C Oxidase"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Irene Vercellino (Institute of Science and Technology Austria, Austria)
"Structure and Assembly of the Mammalian Mitochondrial Supercomplex CIII2CIV"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Shan He (Princeton University, United States)
"Structure and Biogenesis of the Eukaryotic CO2 -Concentrating Organelle, the Pyrenoid"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organelle Metabolism
Discussion Leader: Sabeeha Merchant (University of California, Berkeley, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Ken Nakamura (Gladstone Institutes, United States)
"Understanding and Correcting Energy Failure in Vulnerable Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Veronica Maurino (University of Bonn, Germany)
"Adaptations of C4 Decarboxylases to Their Function in C4 Photosynthesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Natalie Porat-Shliom (Thoracic and GI Malignancies Branch, National Cancer Institute, NIH, United States)
"A Spatial Map of Hepatic Mitochondria Uncovers Functional Heterogeneity and Plasticity at the Tissue Scale"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Jiawen Chen (John Innes Centre, United Kingdom)
"Making a fresh starch: Biochemical regulation of starch granule initiation is distinct in Arabidopsis and wheat"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Franziska Kuhnert (Heinrich-Heine University Düsseldorf, Germany)
"DUF3411 Defines a New Class of Plastidial Amino Acid Transport Proteins"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Yuzhen Fan (The Australian National University, Australia)
"Tales of Mitochondria: How Have the Roles of Mitochondria in C4 Photosynthesis Affected Respiratory Metabolism?"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Aki Matsuoka (Rutgers University, United States)
"Agrobacterium-Mediated Transformation of the Plastid Genome"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Proteostasis, Mitophagy and Chlorophagy
Discussion Leader: Klaas Van Wijk (Cornell University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Hagai Abeliovich (Hebrew University of Jerusalem, Israel)
"The Role of Protein Phosphorylation Within the Mitochondrial Matrix in Regulating the Specificity of Mitophagic Degradation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Einav Gross (Hebrew University of Jerusalem, Israel)
"Development of Novel Oral Drug Aiming at Disease-Free Aging"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Jonathan Friedman (UT Southwestern Medical Center, United States)
"A Non-Canonical Role for Mitochondrial Morphogen TMEM11 as an Inhibitor of the Mitophagy Receptor BNIP3"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Marissa Annis (Cornell University, United States)
"In Vivo Trapping of Substrates and Adaptors of the Chloroplast Clp Chaperone-Protease System"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Yi Sun (Department of Plant Sciences, University of Oxford, United Kingdom)
"Ubiquitination Acts Inside Chloroplasts to Directly Regulate Photosynthesis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signaling and Stress Response
Discussion Leaders: Sally Mackenzie (The Pennsylvania State University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Setsuko Wakao (Lawrence Berkeley National Laboratory, United States)
"Probing Excess Light Response Using Photosynthetic Mutants of Chlamydomonas reinhardtii "
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Derek Narendra (National Institutes of Health, United States)
"OMA1 Mediates Local and Global Stress Responses Against Protein Misfolding in CHCHD10 Mitochondrial Myopathy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Valle Ojeda (University of Seville, Spain)
"Diurnal Cycle in the Green Alga Chlamydomonas reinhardtii at Different Light Intensities"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Florian Schober (Max Planck Institute of Biochemistry, Germany)
"Spatially Resolved Mitochondrial Phospho-Proteomics in Intact Liver Tissue"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Kamel Hammani (CNRS Institute of Plant Molecular Biology, France)
"An Enigmatic Chloroplast Kinase Interacts With the Chloroplast Ribosomal Assembly Factor, mTERF9 and is Important for Arabidopsis Plant Acclimation to Higher Light"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
James Held (Vanderbilt University, United States)
"Altered tRNA Processing Activates the Mitochondrial Unfolded Protein Response"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Dhyan Chandra (Roswell Park Comprehensive Cancer Center, United States)
"Mitochondrial Unfolded Protein Response is Essential for Cancer Cell Survival and Represents a Therapeutic Vulnerability"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Isaac Dopp (Pennsylvania State University, United States)
"The Sensory Plastid is a Discrete Class of Environment-Sensing Plastids That Trigger Epigenetic Phenotypes in Plants"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organelle Biology Translated into Medicine and Agriculture
Discussion Leader: Richard Hartley (University of Glasgow, United Kingdom)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Stephen Long (University of Illinois at Urbana-Champaign, United States)
"Engineering the Plastid for Higher Photosynthetic Efficiency and Food Security - From Math to Field"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Giovanni Manfredi (Weill Cornell Medicine, United States)
"Mitochondria and Degenerative Diseases"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
David Bettoun (Larimar Therapeutics, United States)
"Identification of Differentially Expressed Genes in Friedreich’s Ataxia Patients"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Ralph Bock (Max Planck Institute of Molecular Plant Physiology, Germany)
"Chloroplast Biotechnology and Synthetic Biology"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure