Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Mitochondrial Energy Metabolism and Redox Regulation
Discussion Leader: Paolo Bernardi (University of Padova, Italy)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
Bruce Spiegelman (Dana-Farber Cancer Institute / Harvard Medical School, United States)
"Futile Creatine Cycle: Mechanisms and New Biology"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Anu Suomalainen Wartiovaara (University of Helsinki, Finland)
"Mitochondrial Muscle Disease: A Metabolic Pellagra"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Maik Hüttemann (Wayne State University, United States)
"Noninvasive Treatment of Brain Ischemia-Reperfusion Injury with Near Infrared Light Using Waveguide Technology"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondrial Genome Maintenance and Editing
Discussion Leader: Janine Santos (National Institute of Environmental Health Sciences, NIH, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Bill Copeland (NIEHS, United States)
"Structural Insights of Mitochondrial DNA Replication in Disease"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Carlos Moraes (University of Miami, United States)
"Potential Therapeutic Uses of DNA Editing Enzymes for Mitochondrial Diseases"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Valentina Perissi (Boston University, United States)
"ADP-Ribosylation for the Maintenance of Mitochondrial Homeostasis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Tanja Sack (University of Toronto, Canada)
"Identifying Novel Mitochondrial Stress Response Factors Using Targeted Doxorubicin (mtDox) in Tandem with CRISPR/Cas9 Whole Genome Screening"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Julien Prudent (MRC Mitochondrial Biology Unit, University of Cambridge, United Kingdom)
"Fumarate Accumulation Triggers mtDNA Release to Induce Inflammation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
L. Stirling Churchman (Harvard Medical School, United States)
"Single-Nucleoid Architecture Reveals Heterogeneous Packaging of Mitochondrial DNA"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Agnieszka Chacinska (IMol Polish Academy of Sciences, Poland), Thomas Misgeld ( Technical University of Munich, Germany) and Nadine Hempel (University of Pittsburgh, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mitochondrial Protein Biogenesis
Discussion Leader: Agnieszka Chacinska (IMol Polish Academy of Sciences, Poland)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Thomas Becker (Institute of Biochemistry and Molecular Biology, University of Bonn, Germany)
"Control of Mitochondrial Protein Import"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Taylor Stevens (California Institute of Technology (caltech), United States)
"MTCH2 is a Mitochondrial Outer Membrane Protein Insertase"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Maya Schuldiner (Weizmann Institute of Science, Israel)
"You Take The High Road and I Take The Low Road - Unconventional Routes for Protein Targeting to Mitochondria"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Cole Haynes (UMass Chan Medical School, United States)
"UPRmt and mtDNA Replication in Mitochondrial Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteostasis
Discussion Leader: Giovanni Manfredi (Weill Cornell Medicine, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Erika Holzbaur (University of Pennsylvania, United States)
"Autophagy, Mitophagy, and Inflammation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Heidi McBride (McGill University, Canada)
"Mapping a Common Pathway for Parkinson’s Disease Proteins in Cell Survival and Immunity"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Thomas Langer (Max Planck Institute for Biology of Ageing, Germany)
"Proteolytic Rewiring of Mitochondria at the Interface of Inflammation and Cell Death"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Chris Griffey (Columbia University, United States)
"Parkin, Mitophagy, and Dopaminergic Neuron Stability in the Mammalian Brain"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Angelika Harbauer (MPI for Biological Intelligence, Germany)
"Mitochondrial Health Maintenance in Neurons"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Cynthia McMurray (Lawrence Berkeley National Laboratory, United States)
"Mitochondria. Location Matters"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Natalia Marahori (Technical University Munich, Germany)
"An Optineurin-Dependent Retrograde Transit Filter in Distal Axons Mediates Mitochondrial Quality Control in Synapses"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interorganellar Crosstalk
Discussion Leaders: Ophry Pines (Hebrew University of Jerusalem, Israel)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Meng Wang (HHMI Janelia Research Campus, United States)
"Metabolic Signals in Bacteria-Mitochondria Communication"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Luca Scorrano (University of Padua, Italy)
"Unbiased Screenings Reveal Regulators of Mitochondrial Dynamics and Contact Sites"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Delfina Larrea (Columbia University, United States)
"Altered MAM Function Shifts Mitochondrial Metabolism in SOD1-Mutant Models of ALS"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Michelangelo Campanella (RVC Department of Comparative Biomedical Sciences; UCL Consortium for Mitochondrial Research, United Kingdom)
"The Mitochondrial Sites of Contact with the Nucleus: Regulation and Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondria and Metabolic Regulation
Discussion Leader: Orian Shirihai (UCLA, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Navdeep Chandel (Northwestern University, United States)
"Mitochondria as Signaling Organelles"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Evanna Mills (Dana-Farber Cancer Institute / Harvard Medical School, United States)
"Macrophages and Metabolite Signaling in Metabolic Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Joan Blanco Fernandez (Université de Lausanne, Switzerland)
"Mitochondria Functional Genomics: Genes, Proteins and Alternative Nutrients"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Danielle Grotjahn (Scripps Research, United States)
"Quantifying Mitochondrial Ultrastructure in Cryo-Electron Tomography Using a Surface Morphometrics Pipeline"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Joeva Barrow (Cornell University, United States)
"Leveraging Biogenic Small Molecule Screens Towards the Treatment of Mitochondrial Disease in Primary Muscle Systems"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Karin Busch (University of Münster, Germany)
"Plasticity of Mitochondrial ATP Synthase in Health and Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Priyanka Adla (University of Hyderabad, India)
"Functional Characterization of Mitochondrial Derived Vesicles (MDVs) From Rat Liver"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Erich Gnaiger (Oroboros Instruments, Austria)
"Challenge of the Paradigm on ROS at High Mitochondrial Membrane Potential: Hydrogen Peroxide Production is Independent of Membrane Potential and Q Redox State Under Tissue Normoxia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mitochondrial Carrier Proteins and Transporters
Discussion Leader: Jean-Claude Martinou (university of Geneva, Switzerland)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Edmund Kunji (University of Cambridge, United Kingdom)
"Charge Movements During Adenine Nucleotide Exchange by the Mitochondrial ADP/ATP Carrier"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Jonathan Tai (University of Wisconsin-Madison/Washington University in St. Louis, United States)
"Hem25p is a Mitochondrial Isoprene Transporter"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jared Rutter (University of Utah, United States)
"Metabolism, Cellular Decisions and the Language That Unites Them"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Gyorgy Hajnoczky (Thomas Jefferson University, United States)
"Mitochondrial Apoptosis Mediated Through VDAC2 and Bak is Upregulated in Hepatocarcinoma, Providing an Achilles Heel for Therapy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mitochondria in Senescence and Aging
Discussion Leader: Anu Suomalainen Wartiovaara (University of Helsinki, Finland)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Deborah Croteau (National Institute on Aging, NIH, United States)
"DNA Damage and Mitochondrial Dysfunction in Aging and Neurodegeneration"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Gerald Shadel (Salk Institute for Biological Studies, United States)
"Nucleic Acid-Mediated Mitonuclear Signaling"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Celia Quijano (Universidad de la República, Uruguay, Uruguay)
"Mitochondrial Dynamics and the Senescence-Associated Secretory Phenotype"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Andreia Faria-Pereira (IMM-JLA, Portugal)
"The Unique Bioenergetic Fingerprint of Synaptic Mitochondria"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Francesco Cecconi (Danish Cancer Society Research Center, Copenhagen (Denmark), Denmark)
"The Phosphatase-Dependent Control of Mitochondrial Mass"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Hagai Abeliovich (Hebrew University of Jerusalem, Israel)
"The Pyruvate Dehydrogenase Complex Regulates Mitochondrial Matrix Protein Phosphorylation and Mitophagic Selectivity, Independent of its Catalytic Activity"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Natalie Yivgi Ohana (Minovia Therapeutics, Israel)
"Mitochondrial Augmentation of Hematopoietic Stem Cells: New Learnings Based on Single Cell Analysis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Iron Trafficking and Metabolism
Discussion Leader: Roland Lill (Philipps-Universität Marburg, Germany)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Hélène Puccio (Institut Neuromyogène, France)
"Frataxin Depletion Leads to Decreased Soma Size and Activation of AMPK Metabolic Pathway in Dorsal Root Ganglia Sensory Neurons"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Adam Hughes (University of Utah, United States)
"Mitochondrial Remodeling In Response to Nutrient Stress"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Chao Liang (Duke-NUS Medical School, Singapore)
"Mitochondrial Microproteins Link Metabolic Cues to Respiratory Chain Biogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Halime Kalkavan (Uniklinikum Essen, Germany)
"Persister Act: Translating Cell Death Signaling Into Survival"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
