| Sunday, June 27, 7:30 P.M. | Biochemistry & Genetics of Lipid A Formation |
- 7:30 Site Director's Remarks
- 7:45 *William Dowhan. University of Texas Medical School, Houston,TX
Welcome and Introductions
- 8:00 Christian R. H. Raetz Duke University Medical Center, Durham, NC
Keynote Address: Assembly and Function of Gram-Negative Endotoxin: From Genomics to Structural Biology (Alexander M. Cruickshank Lecturer)
- 9:00 Eckhard Hofmann University of Konstanz, Konstanz, Germany
The X-ray structure of Gram-Negative endotoxin and its interaction with the outer membrane protein FhuA
- 9:45 Welcome Reception
| Monday, June 28, 8:30 A.M. | Lipid Movement & Translocation |
- 8:30 *Dennis R. Voelker. National Jewish Center, Denver, CO
Biochemical and Genetic Analysis of Intracellular Phospholipid Movement
- 9:15 Masato Umeda. Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Regulation of Cell Division by Transbilayer Relocation of Membrane Phospholipids
- 10:00 Coffee Break
- 10:20 Peter J. Sims. Scripps Research Institute, La Jolla, CA
Structure and Function of Plasma Membrane Phospholipid Scramblase: A Protein Mediating Ca2+ Initiated Cell Surface Exposure of Aminophospholipids
- 11:05 Jerome F. Strauss. University of Pennsylvania, Philadelphia, PA
Regulation and Function of STAR, a Sterol Transfer Protein
- 11:50 S. Courtney Frasch. National Jewish Center, Denver, CO
Regulation of Phospholipid Scramblase Activity during Apoptosis by PKCδ
| Monday Afternoon | POSTER SESSION I |
Poster Chair, Charles Rock
| Monday, June 28, 7:30 P.M. | Vesicle Trafficking & Lipid Transfer Proteins |
- 7:30 *Vytas A. Bankaitis. University of Alabama, Birmingham, AL
Role of Phospholipid Transfer Proteins in Cell Function
- 8:15 Howard Riezman.University of Basel, Basel, Switzerlang
Role of Ongoing Ceramide Synthesis in ER to Golgi Transport of GPI-Anchored Proteins
- 9:00 Andy Wurmser. University of Calfornia-San Diego, La Jolla, CA
3'-Phosphoinositide Regulation of Secretory and Endocytic Trafficking Pathways
- 9:45 Kristin B. Hendricks. University of California, Berkeley, Berkeley, CA
Yeast Homolog (Frq1) of Neuronal Frequenin is a Positive Regulator of Phosphatidylinositol 4 Kinase
| Tuesday, June 29, 8:15 A.M. | Lipids as Signaling Molecules |
- 8:15 *George M. Carman. Rutgers University, New Brunswick, NJ
Molecular Characterization and Regulation of Lipid Phosphate Phosphatases
- 9:00 Robert C. Dickson. University of Kentucky College of Medicine, Lexington, KY
Roles for Sphingolipids in Saccharomyces Heat and Nutrient Stress Responses
- 9:45 Coffee Break
- 10:05 Yusuf A. Hannun. Medical University of S. Carolina, Charleston, SC
Sphingolipid Metabolism and the Eukaryotic Stress Response
- 10:50 Stephen M. Prescott. University of Utah, Salt Lake City, Utah
Regulation of cellular responses by diacylglycerol kinases
- 11:35 Vicki A. Sciorra. Stony Brook Health Sciences Center, Stony Brook, NY
Identification of a Phosphoinositide Binding Motif that Mediates Activation of Yeast and Mammalian Phospholipase D Isoenzymes
- 12:00 Meeting Picture
| Tuesday Afternoon | POSTER SESSION I |
Poster Chair, Charles Rock
| Tuesday, June 29, 7:30 P.M. | Genetics & Biochemistry of Sterol Metabolism |
- 7:30 *David Russell. University of Texas Southwestern Medical Center, Dallas, TX
Oxysterols: Regulators and Breakdown Products of Cholesterol Metabolism
- 8:15 Lorena S. Beese. Duke University Medical Center, Durham, NC
Structure and mechanism of protein farnesyl transferase
- 9:00 Michael S. Brown. University of Texas Southwestern Medical Center, Dallas, TX
Regulation of Cholesterol Metabolism
- 9:45 Neale D. Ridgway. Dalhousie University, Halifax, Nova Scotia, Canada
Regulation of Phosphatidylcholine Synthesis by the Sterol Regulatory Element Binding Protein (SREBP) / SREBP Cleavage Activating Protein (SCAP) Pathway
| Wednesday, June 30, 8:30 A.M. | Genetics & Biochemistry of Lipid Metabolism in Somatic Cells |
- 8:30 *Dennis Vance. University of Alberta, Alberta, Canada
Role of PE Methylation in Hepatic Function and Transcriptional Regulation of CTP:Phosphocholine Cytidylyltransferase
- 9:15 Masahiro Nishijima. National Institutes of Infectious Disease, Tokyo, Japan
Sphingomyelin biosynthesis: Studies in CHO mutants resistant to a SM-directed cytolysin
- 10:00 Coffee Break
- 10:20 Salih Wakil. Baylor College of Medicine, Houston, TX
Structure and Mechanism of Fatty Acid Synthase
- 11:05 Martin Post. Hospital for Sick Children, Toronto, Canada
Molecular regulation of CTP:Phosphocholine Cytidylyltransferase in the developing lung
- 11:50 Athanasios Lykides. St. Jude Children's Research Hospital, Memphis, TN
CTP:Phosphocholine Cytidylyltransferase Isoforms: Their Tissue Distribution and Subcellular Localization
| Wednesday Afternoon | POSTER SESSION II |
Poster Chair, Charles Rock
| Wednesday, June 30, 7:30 P.M. | Lipid Metabolism in Microbial Systems |
- 7:30 *Susan Henry. Carnegie Mellon University, Pittsburgh, PA
Regulation of Phospholipid Metabolism in Yeast
- 8:15 Miriam Greenberg. Wayne State University, Detroit, MI
Cardiolipin Biosynthesis and Function in Yeast
- 9:00 Otto Geiger. Technical University of Berlin, Berlin, Germany
Novel Phosphatidyltransferases Involved in Phosphatidylcholine Biosynthesis
- 9:45 Claudia Kent. University of Michigan, Ann Arbor, MI
Structure and Substrate Affinities of Glycerol-3-Phosphate Cytidylyltransferase
| Thursday, July 1, 8:30 A.M. | Protein-Lipid Interactions |
- 8:30 *Ben de Kruijff. Utrecht University, Utrecht, The Netherlands
The Bilayer Paradox of Membranes
- 9:15 Elliott Crooke. Georgetown University Medical Center, Washington, D. C.
Role of Anionic Phospholipids in the Initiation of DNA Replication
- 10:00 Coffee Break
- 10:20 Mikhail Bogdanov. University of Texas Medical School, Houston,TX
Phospholipid-Assisted Folding and Topological Assembly of Membrane Proteins
- 11:05 Ehud Landau. University of Basel, Basel, Switzerland
Crystallization in "cubo": General applicability to membrane proteins
- 11:50 Hans de Cock. University of Utrecht, Utrecht, The Netherlands
Lipopolysaccharide- and Phospholipid-Dependent Folding of Outer Membrane Proteins
| Thursday Afternoon | POSTER SESSION II |
Poster Chair, Charles Rock
| Thursday, July 1, 7:30 P.M. | Fatty Acid and Triacylglycerol Metabolism |
- 7:30 *Rosaland A. Coleman. University of North Carolina, Chapel Hill, NC
Mitochondrial Glycerophosphate Acyltransferase: Regulation of Acyl-CoA Partitioning
- 8:15 Barbara Corkey. Boston University Medical Center, Boston, MA
Physiological Role for Acyl-CoA in Regulation of Insulin Secretion
- 9:00 Charles O. Rock. St. Jude Children's Research Hospital, Memphis, TN
High-Resolution Structure and Mechanism of Type II Fatty Acid Synthesis
- 9:45 Steve J. Smith. Gladstone Institute of Cardiovascular Disease, San Francisco, CA
DGAT Knockout Mice: Obesity Resistance and Evidence for an Alternative Triacylglycerol Synthesis Pathway
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