| Sunday, July 15, 7:30 pm | Lipid: Protein Interactions |
| Discussion Leader: Charles O. Rock, St. Jude Children's Research Hospital |
| 7:30 | Site Director's Remarks |
| 7:45 | Charles O. Rock, St. Jude Children's Research Hospital
Welcome and Introduction |
| 8:00 | William Dowhan, University of Texas Medical School, Houston
"Lipid-assisted Folding of Membrane Proteins: Lipids as Conformational and Topological Determinants" |
| 8:40 | Lukas K. Tamm, University of Virginia
"Role of the lipid bilayer in the folding of membrane proteins" |
| 9:20 | Welcome Reception following presentations |
| Monday, July 16, 9:00 am | Animal Models for Lipid Metabolism |
| Discussion Leader: Suzanne Jackowski, St. Jude Children's Research Hospital |
| 9:00 | Ira Tabas, Columbia University
"Macrophages from CCTa-deficient mice: Phenotypes relevant to atherosclerosis" |
| 9:40 | Constantine Londos, National Institutes of Health
"Knock-out mice reveal the role of perilipin in the management of adipocyte lipid stores" |
| 10:20 | Coffee Break |
| 10:20 | Frank Kuhajda, Johns Hopkins University
"Role of fatty acid synthase activity in metabolic homeostasis" |
| 11:20 | Nada A. Abumrad, State University of New York, Stony Brook
"Animal models for CD36 overexpression and deficiency: testing the Randle hypothesis" |
| 12:00 | Steven A. Farber, Thomas Jefferson University
"Visualizing lipid metabolism in live zebrafish" |
| MONDAY AFTERNOON | POSTER SESSION I |
| Poster Chair, Susan Henry |
| Monday, July 16, 7:30 pm | Peroxisome Function |
| Discussion Leader: Dennis Vance, University of Alberta |
| 7:30 | J. Kalvero Hiltunen, University of Oulu, Finland
"Multifunctional enzymes of peroxisomal b-oxidation" |
| 8:10 | Paul Watkins, Kennedy Krieger Institute
"Acyl-CoA synthetases: new enzymes, new insights" |
| 8:50 | Skaidrite K. Krisans, San Diego State University
"Role of peroxisomes in cholesterol/isoprenoid biosynthesis" |
| 9:30 | Jennifer L. Watts, Washington State University
"C. elegans mutants deficient in polyunsaturated fatty acid synthesis" |
| Tuesday, July 17, 8:40 am | Phosphatidylinositol Regulation of Cell Function |
| Discussion Leader: Christina C. Leslie, National Jewish Center |
| 8:40 | John D. York, Duke University
"Nuclear phosphatidylinositol metabolism and mRNA export" |
| 9:20 | Tadaomi Takenawa, University of Tokyo, Japan
"Regulation of cytoskeletal re-organization and membrane trafficking by inositol phospholipids" |
| 10:00 | Coffee Break |
| 10:30 | George Carman, Rutgers University
"Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase" |
| 11:10 | Suzanne Scarlata, State University of New York, Stony Brook
"How the pleckstrin homology domains of phospholipase C serve multiple roles in enzyme regulation" |
| 11:50 | John H. Evans, National Jewish Medical and Research Center
"Intracellular calcium signals regulate cPLA2 translocation to Golgi and ER" |
| TUESDAY AFTERNOON | POSTER SESSION I |
| Poster Chair, Susan Henry |
| Tuesday, July 17, 7:30 pm | Membrane Microdomains |
| Discussion Leader: Vytas Bankaitis, University of Alabama, Birmingham |
| 7:30 | Deborah A. Brown, State University of New York at Stony Brook
"Structure of lipid rafts" |
| 8:10 | Eric J. Smart, University of Kentucky
"Caveolin and intracellular cholesterol trafficking" |
| 8:50 | Hansgeorg Schindler, University of Linz, Austria
"Lipid rafts in cell membranes analyzed by single molecule microscopy" |
| 9:30 | Masayoshi Fukasawa, National Institute of Infectious Diseases, Tokyo, Japan
"Behavior of cholesterol and GPI-anchored proteins in CHO cells defective in sphingolipid synthesis" |
| Wednesday, July 18, 8:40 am | Intracellular Trafficking |
| Discussion Leader: Dennis Voelker, National Jewish Center |
| 8:40 | Daniela Corda, Instituto di Ricerche Farmacologiche, Italy
"Role of the lysophosphatidic acid acyltransferase activity of CtBP3/BARS in Golgi membrane fission" |
| 9:10 | Jean E. Vance, University of Alberta, Canada
"Synthesis and transport of lipids for neuronal axon growth" |
| 10:00 | Coffee Break |
| 10:30 | Christoph Benning, Michigan State University
"Glycolipid biosynthesis and lipid trafficking in the model plant Arabidopsis thaliana" |
| 11:10 | Andreas Conzelmann, University of Fribourg, Switzerland
"Lipid remodeling and transport of GPI anchored proteins in S. cerevisiae" |
| 11:50 | Thomas J. F. Nieland, Harvard Medical School
"Chemical genetics: discovery of cholesterol ester uptake inhibitors" |
| WEDNESDAY AFTERNOON | POSTER SESSION II |
| Poster Chair, Susan Henry |
| Wednesday, July 18, 7:30 pm | Structure and Function in Lipid Enzymology |
| Discussion Leader: Judy Storch, Rutgers University |
| 7:30 | William L. Smith, Michigan State University
"Interactions of fatty acid substrates with cylclooxygenases" |
| 8:10 | Matilda Katan, Institute for Cancer Research, London
"Structure and function of PI-PLC" |
| 8:50 | Ta Yuan Chang, Dartmouth University
"Structure and function of ACAT" |
| 9:30 | Anna A. Noga, University of Alberta
"A specific role for PEMT-derived PtdCho in the secretion of VLDL" |
| Thursday, July 19, 8:40 am | Regulation of Lipid Metabolism |
| Discussion Leader: Rosalind Coleman, University of North Carolina |
| 8:40 | Hei Sook Sul, University of California, Berkeley
"Regulation of fat synthesis" |
| 9:10 | Timothy F. Osborne, University of California, Irvine
"Differential regulation of gene expression by the nutrient sensing SREBPs" |
| 10:00 | Coffee Break |
| 10:30 | James M. Ntambi, University of Wisconsin
"The Regulation of Stearoyl-CoA desaturase 1: Role in Lipid Metabolism" |
| 11:10 | Susan A. Henry, Cornell University
"The Role of signal transduction pathways in regulation of phospholipid synthesis in yeast" |
| 11:50 | Scot Stone, Gladstone Institute of Cardiovascular Disease
"Identification of a second diacylglycerol acyltransferase" |
| THURSDAY AFTERNOON | POSTER SESSION II |
| Poster Chair, Susan Henry |
| Thursday, July 19, 7:30 pm | Lipid Biosynthesis in Microorganisms |
| Discussion Leader: William Dowhan, University of Texas Medical School, Houston |
| 7:30 | Christian R. H. Raetz, Duke University
"Genomic insights into procaryotic phospholipid biosynthesis and secretion" |
| 8:10 | Steve W. White, St. Jude Children's Research Hospital
"Structure and mechanism in type II fatty acid biosynthesis" |
| 8:50 | Clif E. Barry, National Institutes of Health
"Mycobacterial lipid synthesis: a target for old (and new?) antibiotics" |
| 9:30 | Joseph T. Nickels, MCP Hahnemann University
"Sterol-dependent regulation of sphingolipid synthesis in saccharomyces cerevisiae" |
