| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:55 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:55 pm - 9:30 pm | Keynote Lectures: Lipid Structure and Function from Microbes to Mammals |
| Discussion Leader: Bill Dowhan (University of Texas - Houston College of Medicine) |
| 7:40 pm - 8:25 pm | Christian Raetz (Duke University)
"Role of Structural Lipidomics in Genome Annotation"
(In Honor of Eugene Kennedy)
|
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:20 pm | Dennis Vance (University of Alberta)
"Phosphatidylcholine biosynthesis, homeostasis, and function"
(In Memory of Konrad Bloch) |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Structure and Catalysis at the Lipid:Protein Interface |
| Discussion Leaders: David Russell (UT Southwestern Medical School) / Christian Raetz (Duke University) |
| 9:00 am - 9:30 am | Stephen White (University of California, Irvine)
"Lipid-Protein Interactions In Biological Membranes: A Marriage Of Convenience?" |
| 9:30 am - 9:35 am | Discussion |
| 9:35 am - 10:05 am | John Shanklin (Brookhaven Laboratories)
"Lipid-Protein Structural Modeling And The Engineering Of Novel Catalytic Centers For Lipid Biosynthesis" |
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:25 am | William T. Lowther (Wake Forest University)
"Crystal Structure of the Thioesterase Domain of Human Fatty Acid Synthase Complexed with the Anti-Tumor Compound Orlistat: Molecular Basis for Inhibition and Chain-Length Selectivity" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Coffee Break / Group Photo |
| 10:50 am - 11:20 am | Bill Dowhan (University of Texas - Houston College of Medicine)
"Interaction Between Lipids And Extramembrane Domains Of Proteins As Determinants Of Membrane Protein Topogenesis" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am | Charles Rock (St. Jude Children’s Research Hospital, Memphis)
"Structure and function of a soluble diacylglycerol kinase" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Kalervo Hiltunen (University of Oulu, Finland)
"3-hydroxyacyl thioester dehydratase from human - a link between mitochondrial fatty acid synthesis and RNA processing?" |
| 12:15 pm - 12:30 pm | General discussion:
"Critical problems in lipid molecular interactions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lipid Dysfunction and Metabolic Disease |
| Discussion Leader: Jean Vance (University of Alberta) |
| 7:30 pm - 8:00 pm | Shulman, Gerald (Yale)
"Dysregulated Lipid Metabolism in the Pathogenesis of Type 2 Diabetes" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Jean Schaffer (Washington University School of Medicine)
"Mechanisms of Lipotoxicity" |
| 8:35 pm - 8:40 pm | Discussion |
|
8:40 pm - 8:55 pm | Xianlin Han (Washington University School of Medicine)
"Alterations in Cardiolipin Content and Molecular Species Composition Link Diabetic Cardiomyopathy and Mitochondrial Dysfunction in Murine Models of Diabetes" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Jay Horton (UT Southwestern Medical Center)
"Molecular Mediators of Hepatic Steatosis" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Lipid Metabolic Regulation |
| Discussion Leader: Susan Henry (Cornell University) |
| 9:00 am - 9:30 am | Diego DeMendoza (Institute of Molecular and Cell Biology, University of Rosario, Argentina)
"Sensing Lipid Fluidity in Bacterial Membranes" |
| 9:30 am - 9:35 am | Discussion |
| 9:35 am - 10:05 am | George Carman (Rutgers University)
"Roles of Phosphatidic Acid Phosphatase in the Regulation of Fat Metabolism" |
| 10:05 am - 10:10 am | Discussion |
| 10:10 am - 10:25 am | Li-Ping Sun
"Sterol-regulated Transport from Endoplasmic Reticulum to Golgi: Sterols Render Sorting Signals in SCAP Inaccessible to COPII Proteins" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:20 am | Russell DeBose-Boyd (UT Southwestern Medical Center)
"Defining the Molecular Mechanism for Sterol-Accelerated Degradation of HMG CoA Reductase" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:55 pm | Takanari Inoue (Stanford University)
"Chemically-Inducible Manipulation of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 In Situ as Probes of Phosphoinositide Regulatory Functions" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Thomas Lyons (University of Florida)
"Characterizing the Role of Sphingolipids in the Function of Membrane Steroid Receptors" |
| 12:15 pm - 12:30 pm | General Discussion:
"Critical problems in lipid regulation and metabolic dysfunction" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lipid Movement |
| Discussion Leader: Sepp Kohlwein (University of Graz, Austria) |
| 7:30 pm - 8:00 pm | Judith Storch (Rutgers University)
"Intracellular Lipid Transport: the Role of Niemann-Pick C2 Protein" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | John F. Oram (University of Washington)
"Regulation of ABC Cholesterol Transporters" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Xiayang Qiu (Pfizer, Groton, CT)
"Structure and Lipid Transfer Function of Cholesterol Ester Transfer Protein" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Concetta DiRusso (Ordway Institute)
"Vectorial Acylation and Fatty Acid Transport in Mammalian Cells" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Lipid Metabolic Engineering |
| Discussion Leader: Teresa Dunn (Armed Forces University) |
| 9:00 am - 9:30 am | John Browse (Washington State University)
"Molecular Approaches to Modifying Seed Lipid Composition" |
| 9:30 am - 9:35 am | Discussion |
| 9:35 am - 10:05 am | Anthony Kinney (Pioneer Crop Genetics Research, DuPont Experimental Station)
"Engineering Fatty Acid Biosynthetic Pathways to Produce Novel Lipids" |
| 10:05 -10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Christoph Benning (Michigan State University)
"Designing biofuel crops: Regulation and
Engineering of Triacylglycerol Content in Plants" |
| 11:00 am - 11:05 am | Discussion |
| 11:05 am - 11:35 am | Henry Valentin (Monsanto Corporation)
"Metabolic Engineering of Plants and Microbes for the Production of Lipid Nutrients and Polymers" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Naren Yadav (Dupont Corporation)
"Fungal ω-3 Desaturases: Substrate Specificities and Use in Microbial Production of ω-3 Fatty Acids" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion:
"Critical Problems in Lipid movement, Lipid Metabolic Engineering" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session C |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Lipid Dynamics in Infection and Immunity |
| Discussion Leader: Dennis Voelker (National Jewish Research Center, Denver) |
| 7:30 pm - 8:00 pm | Albert Bendelac (HHMI, University of Chicago)
"Lipid Trafficking and Processing for Presentation by CD1 Molecules" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Christina Leslie (National Jewish Research Center, Denver)
"Regulation of cPLA2, COX2 and Eicosanoids in Macrophages by Fungal and Bacterial Pathogens" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Rama K. Mallampalli (University of Iowa)
"Calmodulin Binds and Stabilizes the Regulatory Enzyme, CTP:phosphocholine Cytidylyltranferase under Pro-Inflammatory Stress" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Dennis Voelker (National Jewish Research Center, Denver)
"Regulation of Innate Immunity by Pulmonary Surfactant Phospholipids" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Fat Deposition and Turnover |
| Discussion Leader: George Carman (Rutgers University) |
| 9:00 am - 9:30 am | Guenther Daum (Technical University of Graz, Austria)
"The Life Cycle of Neutral Lipids: Synthesis, Storage and Degradation" |
| 9:30 am - 9:35 am | Discussion |
| 9:35 am - 10:05 am | Robert Farese (Gladstone Institute of Cardiovascular Disease)
"Mechanisms of Fat Synthesis and Storage" |
| 10:05 - 10:10 am | Discussion |
| 10:10 am - 10:25 am | Rosalind Coleman (University of North Carolina, Chapel Hill)
"How Many GPATs do We Need?" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:20 am | Dominique Langin (INSERM Institut Louis Bugnard, Toulouse)
"Lipolysis and Lipases in Human White Adipose Tissue" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am | Karen Reue (UCLA-Los Angeles)
"Lipin - the MIssing LInk in TG Synthesis in Fat and Muscle" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Peter Oelkers (Drexel University)
"Identification and Characterization of a Novel Lysophosphatidylcholine Acyltransferase in S. cerevisiae" |
| 12:15 pm - 12:30 pm | General Discussion:
"Critical Problems in Immune Lipidology and Fat Deposition" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session D |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Regulation of Lipid Homeostasis |
| Discussion Leader: Suzanne Jackowski (St. Jude Children’s Research Hospital) |
| 7:30 pm - 8:00 pm | James Ntambi (University of Wisconsin - Madison)
"Stearoyl-CoA Desaturase and Regulation of Energy Homeostasis" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:35 pm | Dan Ory (Washington University)
"Oxysterol Regulation of Cholesterol Homeostasis" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | John S Burg (Johns Hopkins)
"INSIG Regulates HMG-CoA Reductase by a Non-Degradative Mechanism in Fission Yeast" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:15 pm | Andrew J Brown (Univ. New South Wales, Sydney, Australia)
"New Insights into 24(S),25-Epoxycholesterol’s Role in Cholesterol Homeostasis" |
| 9:15 pm - 9:30 pm | General Discussion:
"Critical Problems in Lipid Homeostasis" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
