Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Lipid Dynamics and Lipidomics |
| Discussion Leader: Suzanne Jackowski (St. Jude Children's Research Hospital, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:25 pm | Todd Graham (Vanderbilt University, USA) "Probing How and Why P4-ATPases Flip Phospholipid" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:10 pm | Daniel Nomura (University of California, Berkeley, USA) "Mapping Dysregulated Lipid Metabolism in Disease Using Chemoproteomic and Metabolomics Platforms" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cellular Trafficking of Lipids |
| Discussion Leader: George Carman (Rutgers University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:45 am | Thomas Langer (University of Cologne, Germany) "Intramitochondrial Phospholipid Trafficking" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Madhavan Chalat (University of British Columbia, Canada) "C-Terminal Domain of Atp8a2 Is Involved in Auto-Regulation of Flippase Activity" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Group Photo / Coffee Break |
10:40 am - 11:15 am | Symeon Siniossoglou (University of Cambridge, United Kingdom) "Coordination of Membrane and Storage Lipid Homeostasis by Lipin" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Masaki Tsuchiya (Graduate School of Engineering, Kyoto University, Japan) "The Role of Phospholipid Flippases in Myotube Formation" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:15 pm | Will Prinz (National Institutes of Health, USA) "ER-Golgi Contacts and Ceramide Toxicity" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lipid Responses to Challenge |
| Discussion Leader: Daniel Raben (Johns Hopkins University, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:15 pm | Nan Chiang (Harvard Medical School, USA) "Novel Actions of Specialized Pro-Resolving Mediators in Promoting Resolution of Inflammation and Infection" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Gregory Fairn (St. Michael's Hospital, University of Toronto, Canada) "Mutual Requirement of Cholesterol and Phosphatidylserine in the Cytosolic Leaflet of the Plasma Membrane" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Frank Gonzalez (National Cancer Institute, NIH, USA) "Ceramides and Metabolic Disease" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lipid Signaling |
| Discussion Leader: Dennis Voelker (National Jewish Health, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:45 am | Lois Weisman (University of Michigan, USA) "Role and Regulation of PI(3,5)P2 and PI5P: Signaling Lipids with Links to Neurodegeneration" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Scott Hansen (The Scripps Research Institute, USA) "Lipid Gating of Ion Channels" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:15 am | Rajat Rohatgi (Stanford University School of Medicine, USA) "Signal Transduction by Oxysterols" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Xinxin Gao (Genentech, USA) "Single-Cell In Situ Imaging of Wnt Palmitoylation" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:15 pm | Richard Proia (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) "Imaging Sphingolipid Signaling in Live Mice" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Responses to Lipid Challenge |
| Discussion Leader: Paul Black (University of Nebraska, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:15 pm | Tobias Walther (Harvard T.H. Chan School of Public Health, USA) "Molecular Mechanisms and Consequences of Cellular Neutral Lipid Storage" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Stephen Jesch (Cornell University, USA) "Inositol-Dependent Changes in Sphingolipid Metabolism Regulate Stress Response Signaling" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Clay Semenkovich (Washington University, USA) "Lipogenesis, Metabolic Signaling, and Adaptation to Obesity" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Disease Mechanisms |
| Discussion Leader: Rosalind Coleman (University of North Carolina, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:45 am | Michael Schlame (New York University School of Medicine, USA) "Aberrant Cardiolipin Dynamics in Barth Syndrome" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Martin Pagac (University of New South Wales, School of Biotechnology and Biomolecular Sciences, Australia) "SEIPIN Is an Evoluationarily Conserved Regulator of Glycerol-3-Phosphate Acyltransferase (GPAT)" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:15 am | Michael Wolfgang (Johns Hopkins University, USA) "Role of Adipocyte Fatty Acid Oxidation in Obesity and Diabetes" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Baran Ersoy (Brigham and Women's Hospital / Harvard Medical School, USA) "Regulation of Endoplasmic Reticulum (ER) Calcium Homeostasis by Thioesterase Superfamily Member 2 (Them2): Pathogenic Role in Non-Alcoholic Fatty Liver Disease (NAFLD)" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:15 pm | Noa Noy (Cleveland Clinic, USA) "Long Chain Fatty Acids Regulate Transcription and Modulate Cancer Cell Growth by Targeting FABP5" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Targeting Lipid Metabolism |
| Discussion Leader: Judith Storch (Rutgers University, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:15 pm | Alex Brown (Vanderbilt University, USA) "Phosphatidic Acid Pathways as Therapeutic Targets in Cancer and Infectious Disease" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Alenka Copic (Institute Jacques Monod, CNRS UMR 7592, France) "How Differential Membrane Lipid Composition Is Maintained in Cells and Used for Selective Recruitment of Amphipathic Helices" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Michael Wakelam (University of Cambridge, United Kingdom) "Lipidomic Analysis of Cancer Cells and Tissues" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Microbial Interaction with Host Lipid Metabolism |
| Discussion Leader: James Ntambi (University of Wisconsin-Madison, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:45 am | Andrew Tai (University of Michigan Medical School, USA) "Reorganizing Cellular Membranes to Support RNA Virus Replication" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Swapna Apte (Purdue University, USA) "Functions of Specific Sphingolipids in Dengue Virus Infection" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:15 am | Dennis Voelker (National Jewish Health, USA) "Anionic Phospholipid Protection from Respiratory Virus Infections" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Daniel Ferguson (Cleveland Clinic Foundation, USA) "Hepatitus C Virus-Driven Depatic Steatosis Requires the Lipid Droplet Scaffold Protein TIP47" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:15 pm | Charles Rock (St. Jude Children's Research Hospital, USA) "Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Technological Advances in Lipid Biology |
| Discussion Leader: David Bernlohr (University of Minnesota, Twin Cities, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:10 pm | Arthur Laganowsky (Texas A&M Health Science Center, USA) "Advances in Ion Mobility Mass Spectrometry of Intact Membrane Protein-Lipid Complexes" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Paul Black (University of Nebraska, USA) and Alan Kleinfeld (Membrane Sciences, USA) "Unbound FFA Profiles as a New Window on Physiological Active Metabolites" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Peter Watson (Cardiff University School of Biosciences, United Kingdom) "Hyperspectral and Differential CARS Microscopy for Quantitative Imaging of Cellular Lipids" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |