Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Lipids in Signaling and Metabolism
Discussion Leader: David Bernlohr (University of Minnesota, Twin Cities, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Rosalind Coleman (University of North Carolina at Chapel Hill, USA)
"Compartmentalizing Lipid Metabolism"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
Jean Schaffer (Washington University in St. Louis, USA)
"RNA Regulation of Lipotoxicity"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Intracellular Lipid Storage and Utilization
Discussion Leader: Judith Storch (Rutgers University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:45 am
Brian Finck (Washington University in St. Louis, USA)
"Convergent Pathways of Diacylglycerol Synthesis or Only the Tip of the Iceberg?"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Mike Renne (Utrecht University, The Netherlands)
"Crosstalk Between Membrane Lipid Unsaturation and Inter-Organelle Lipid Transport"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:15 am
Dawn Brasaemle (Rutgers University, USA)
"Investigating the Function of CGI-58, an Enigmatic Protein"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Andrew Hoy (University of Sydney, Australia)
"Lipid Droplet Proteome and Phospho-Proteome Reveals Role of Key Proteins in the Pathogenesis of Hepatic Insulin Resistance"
11:35 am - 11:40 am
Discussion
11:40 am - 12:15 pm
Douglas Mashek (University of Minnesota, USA)
"ACOT1: A Regulatory Node in Fatty Acid Signaling and Metabolism"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Autophagy and Lipid Metabolism
Discussion Leader: Jean Schaffer (Washington University in St. Louis, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:15 pm
Martin Graef (Max Planck Institute for Biology of Aging, Germany)
"Acyl-CoA Synthetases Drive Autophagy"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Selected from Poster Abstracts: Angela Corcelli (University of Bari Aldo Moro Italy, Italy)
"MALDI/TOF MS Lipid Analyses of Melanoma Cells and Their Exosomes"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Jennifer Lippincott-Schwartz (Howard Hughes Medical Institute, USA)
"Dissecting the Mechanism for Micro-Lipophagy in Yeast and Its Role in Lifespan Extension Under Starvation"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Intracellular Lipid Trafficking
Discussion Leader: Rosalind Coleman (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:45 am
Silvana Zanlungo (Pontificia Universidad Catolica de Chile, Chile)
"Pathogenic Mechanisms in Niemann-Pick Type C Cholesterol Storage Disease"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Yongqiang Deng (Yale University, USA)
"Sphingomyelin Is Sorted at the Trans Golgi Network into a Distinct Class of Secretory Vesicles"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:15 am
Judith Storch (Rutgers University, USA)
"Cholesterol Trafficking in Niemann-Pick C Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Maria Gonzalez-Baro (Universidad Nacional de La Plata, Argentina)
"GPAT3 and GPAT4 Direct Glycerolized De Novo Synthesis in Activated Macrophages and Their Down-Regulation Alters Macrophage Functionality"
11:35 am - 11:40 am
Discussion
11:40 am - 12:15 pm
Jessica Ellis (Purdue University, USA)
"Fatty Acid Oxidation Is Required for the Working Heart: Lessons from Cardiac CPT2 Deficiency"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Microbiome and Lipid Metabolism
Discussion Leader: Douglas Mashek (University of Minnesota, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:15 pm
Itay Budin (University of California, Berkeley, USA)
"Metabolic Engineering of Membrane Lipid Composition in Model Organisms"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Selected from Poster Abstracts: Minal Mulye (Indiana University School of Medicine, USA)
"Altering Lipid Droplet Homeostasis Affects Coxiella burnetii Intracellular Growth"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
M. Stephen Trent (University of Georgia, USA)
"The Power of Asymmetry: Architecture and Assembly of the Gram-Negative Outer Membrane Lipid Bilayer"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Microdomains: Structure and Function
Discussion Leader: Dawn Brasaemle (Rutgers University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:45 am
Mary Kraft (University of Illinois at Urbana-Champaign, USA)
"Does the Influenza Virus Bud from Membrane Domains Enriched with Cholesterol and Sphingolipids?"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Marc Pilon (University of Gothenburg, Sweden)
"The AdipoR and FLD-1 Pathways Protect Cellular Membranes Against Rigidifying Exogenous Saturated Fatty Acids"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:15 am
Vanina Zaremberg (University of Calgary, Canada)
"Dynamic Pools of Diacylglycerol Define Vacuolar Morphology and Plasma Membrane Sites of Polarized Growth in Budding Yeast"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: McKenna Feltes (Washington University in St. Louis, USA)
"Diazirine Alkyne (DA) Probes as Tools for the Study of Intracellular Cholesterol Trafficking"
11:35 am - 11:40 am
Discussion
11:40 am - 12:15 pm
Paul Pilch (Boston University, USA)
"Dual Functions of PTRF/Cavin-1 in the Etiology of Type 4 CGL"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation and Function of Phospholipid Metabolism
Discussion Leader: Todd Graham (Vanderbilt University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:15 pm
Steven Claypool (Johns Hopkins University, USA)
"Rewiring Mitochondrial Phosphatidylethanolamine Metabolism in Yeast"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Selected from Poster Abstracts: Grant Hatch (University of Manitoba, Canada)
"Altered Islet Function May Promote a Lean Phenotype in Tafazzin Knockdown Mice"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Nihal Altan-Bonnet (National Institutes of Health, USA)
"Viral Propagation in Vesicles: Pooped out or Pathogenic?"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Lipid-Mediated Signal Transduction
Discussion Leader: Brian Finck (Washington University in St. Louis, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:45 am
Heather Bradshaw (Indiana University, USA)
"Lipoamines: An Emerging Class of Novel Lipid Signaling Molecules"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Christopher Horoszko (Memorial Sloan Kettering Cancer Center, USA)
"A RAS-ERK Stress Response Triggers Phospholipid Catabolism in the Secretory Endosomal Pathway"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:15 am
George Carman (Rutgers University, USA)
"Phosphatidic Acid Phosphatase Regulates Phospholipid Synthesis via Phosphatidylserine Synthase"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Maria Karmella Apaya (Academia Sinica, Taiwan)
"Bioactive Lipids in Triple Negative Breast Cancer: Epoxyeicosatrienoic Acids as Metabolic and Metastasis Drivers"
11:35 am - 11:40 am
Discussion
11:40 am - 12:15 pm
Nils Faergeman (University of Southern Denmark, Denmark)
"Regulation of De Novo Sphingolipid Synthesis by Directional Acyl-CoA Channeling"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Transcriptional Control in Lipid Metabolism
Discussion Leader: Nils Faergeman (University of Southern Denmark, Denmark)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:15 pm
Soonkyu Chung (University of Nebraska, USA)
"Dietary n-3 PUFA Increases Brown Adipogenesis Through miRNA-Associated Mechanisms"
6:15 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
Selected from Poster Abstracts: Cunqi Ye (University of Texas Southwestern Medical Center, USA)
"An Unforeseen Function for Phospholipid Methylation in Cellular Metabolism and Maintenance of the Epigenome"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 7:15 pm
Timothy Osborne (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Setting the Stage for SREBP Dependent Regulation of Hepatic Lipid Metabolism"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure