| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:38 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:38 pm - 9:30 pm | Brain Functions & Diseases |
| Discussion Leader: Yi Sun (UCLA) |
| 7:38 pm - 7:58 pm | Gero Miesenbock (University of Oxford)
"Optogenetics of Choice" |
| 7:58 pm - 8:06 pm | Discussion |
| 8:06 pm - 8:26 pm | Minmin Luo (National Inst. of Biological Science, Beijing)
"Membrane Guanylyl Cyclase Signaling in the Brain" |
| 8:26 pm - 8:34 pm | Discussion |
| 8:34 pm - 8:54 pm | Eric Huang (Univ. of California, San Francisco)
"RNA Binding Proteins and Neurodegeneration" |
| 8:54 pm - 9:02 pm | Discussion |
| 9:02 pm - 9:22 pm | Wen-Cheng Xiong (Georgia Health Sciences University)
"Retromer and Neurodegeneration" |
| 9:22 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanisms of Cognition |
| Discussion Leader: Louis Reichardt (University of California, San Francisco) |
| 9:00 am - 9:20 am | James Bibb (UT Southwestern Medical School)
"Regulation of NMDA receptor trafficking in cognition" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Yi Rao (Peking University, Beijing)
"Genetic Studies of Social Behaviors and Cognition" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Yi Sun (UCLA)
"MicroRNAs involved in cognition" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Group Photo / Coffee Break |
| 10:50 am - 11:30 am | Keynote Lecture I: Rick Huganir (Johns Hopkins University)
"Regulation of Neurotransmitter Receptor Function and Synaptic Plasticity in the Brain" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Linda Wilbrecht (Univ. of California, San Francisco)
"Weighing a choice to turn left or right: manipulation of decision making by targeted stimulation of striatal circuits in mice" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Short Talk: Michael Lin (Stanford University)
"Visualizing stimulus-induced synaptic tagging by newly synthesized PSD95"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:00 pm - 12:27 pm | Short Talk: Da-Ting Lin (Jackson Laboratory)
"Regulation of dopamine D2 receptor function by endosomal recycling pathways"
|
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Neural Development |
| Discussion Leader: Shernaz Bamji (University of British Columbia) |
| 7:30 pm - 7:50 pm | Yi-Ping Hsueh (Academia Sinica, Taipei)
"Neuronal Innate Immunity Regulates Neuronal Morphogenesis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Nobutaka Hirokawa (University of Tokyo)
"Instracellular Transport of Synaptic Vesicle Precursors by KIF1A and NMDA Receptors by KIF17 and Regulation of Memory and Learning" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | David Ginty (Johns Hopkins University)
"Organization and Development of Neurons that Underlie the Sense of Touch" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | John Rubenstein (University of California, San Francisco)
"Transcriptional Control of Neuronal Identity in the Telencephalon" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Neuronal Polarity, Synapses and Circuitry |
| Discussion Leader: James Zheng (Emory University) |
| 9:00 am - 9:20 am | Zhenge Luo (Institute of Neuroscience, CAS, Shanghai)
"Membrane trafficking mechanism underlying neuronal polarization" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Hollis Cline (Scripps, San Diego)
"Experience-Dependent Visual Circuit Development" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Mriganka Sur (MIT)
"Cell-specific circuits in the cerebral cortex" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Vivian Budnik (Univ. of Massachusetts)
"Getting the Message Out" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:50 am | Eunjoon Kim (KAIST, South Korea)
"Synaptic Scaffolds and Autism Spectrum Disorders" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:07 pm | Short Talk: Hao Wu (Johns Hopkins University)
"Morphologic diversity of cutaneous sensory nerve endings revealed by genetically directed sparse labeling"
|
| 12:07 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Short Talk: Bing Ye (University of Michigan)
"Dscam expression levels determine synaptic terminal arbor sizes in Drosophila"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:00 pm - 12:27 pm | Short Talk: Amy Fu (Hong Kong University of Science and Technology)
"Roles of α2-chimaerin in neural circuit wiring and function"
|
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Brain Disorders and Risk Genes |
| Discussion Leader: Huaibin Cai (National Institute of Aging, NIH) |
| 7:30 pm - 7:50 pm | Kozo Kaibuchi (Hagoya University)
"Roles of the DISC1 gene in neural development and behaviors" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Guo-Li Ming (Johns Hopkins University)
"Regulation of neuronal development by risk genes for brain disorders: From mice to humans" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Akira Sawa (Johns Hopkins University)
"Oxidative stress and transient inflammation around the onset of adult mental illness: translational approach for schizophrenia" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Christian Rosenmund (Charite Univ. Medicine, Berlin)
"Molecular mechanism of neurotransmitter release at central synapses" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Brain Wiring and Plasticity |
| Discussion Leader: John Ngai (University of California, Berkeley) |
| 9:00 am - 9:20 am | Nancy Ip (Hong Kong University of Science & Technology)
"Molecular control of proliferation and differentiation in neurogenesis" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Oscar Marin (Instituto de Neurosciencias de Alicante, CSIC-UMH)
"Molecular Mechansims Controlling the Assembly of Cortical Inhibitory Circuits" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Gordon Fishell (New York University)
"Activity regulated gene expression directs the positioning and maturation of cortical interneurons" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:30 am | Keynote Lecture II: Robert Malenka (Stanford University)
"Behavioral Implication of Cell-Type synaptic Plasticity in Mesolimbic Dopamine circuitry" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Bob Horvitz (MIT)
"Replication-Coupled Chromatin Assembly Generates a Neuronal Bilateral Asymmetry in C. elegans" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Short Talk: Tian-Ming Gao (Southern Medical University, Guangzhou)
"Astrocyte-derived ATP modulates depressive-like behaviors"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Short Talk: Shi-Bing Yang (Univ. of California, San Francisco)
"Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons"
|
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair; Poster Awards |
| 7:30 pm - 9:30 pm | Glia and Neural Stem Cells |
| Discussion Leader: Hongjun Song (Johns Hopkins University) |
| 7:30 pm - 7:37 pm | Short Talks: Kurt Haas (University of British Columbia)
"MEF2 mediates functional and structural metaplasticity in the awake developing brain"
|
| 7:37 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:47 pm | Short Talk: Ron Yu (Stowers Institute)
"Recognition of Complex Urinary Cues by the Mouse Vomeronasal Organ"
|
| 7:47 pm - 7:50 pm | Discussion |
| 7:50 pm - 7:57 pm | Short Talk: Siew-Lan Ang (MRC National Institute for Medical Research)
"Out-foxing dopamine neurons"
|
| 7:57 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Yoshiki Sasai (RIKEN, Japan)
"Self-organization of neural structures in 3D stem cell culture" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Jovica Ninkovic (Ludwig-Maximilians Univ., Munich)
"Molecular mechanisms of neurogenesis from glial cells" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Shuming Duan (Zhejiang University)
"Mechanisms and pathological relevance of ATP-induced Macropinocytosis in microglia" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Neurotransmission and Plasticity |
| Discussion Leader: Jun Xia (Hong Kong University of Science and Technology) |
| 9:00 am - 9:20 am | Bai Lu (GSK China)
"BDNF as a therapeutic strategy for synaptic degenerative diseases" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Katherine Roche (National Institute of Neurological Disorders and Stroke, NIH)
"Molecular Mechanisms Regulating Plasticity at Excitatory Synapses" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Roger Nicoll (Univ. of California, San Francisco)
"What domains of the AMPA receptor are required for synaptic trafficking and plasticity?" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Martha Constantine-Paton (MIT)
"Cell Biology and Behavior of a MyoVa Mutant Mouse: A Possible Inroad to Autism" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 12:00 pm | Keynote Lecture III: Aaron Ciechanover (Israel Inst. of Tech., Haifa)
"The Ubiquitin proteolytic System: From Basic Mechanisms thru Human Disease and on to Drug targeting" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:17 pm | Short Talk: Weichun Lin (UT Southwestern)
"Synaptic activity and Glia-less synapse"
|
| 12:17 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:27 pm | Short Talk: Rick Rotundo (University of Miami)
"Translational Control of Acetylcholinesterase at the Neuromuscular Synapse"
|
| 12:27 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Synapse Formation |
| Discussion Leader: Rick Rotundo (University of Miami) |
| 4:00 pm - 4:20 pm | Kang Shen (Stanford University)
"Extrinsic and Intrinsic Mechanisms of Synapse Formation and Maintenance" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 4:50 pm | Michael Granato (Univ. of Pennsylvania)
"Wnt Induced Endocytosis Determine Neuromuscular Synapse Position" |
| 4:50 pm - 5:00 pm | Discussion |
| 5:00 pm - 5:20 pm | Kuo-Fen Lee (Salk Institute)
"Glia, activity and thrombin in neuromuscular synapse development" |
| 5:20 pm - 5:30 pm | Discussion |
| 5:30 pm - 5:50 pm | Patricia Salinas (Univ. College London)
"The birth and death of the synapse: a role for Wnt signaling" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
