Sunday |
2:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Synapse Formation and Synaptic Plasticity |
| Discussion Leader: Rafael Fernandez-Chacon (Instituto de Biomedicina de Sevilla (IBiS) / Universidad de Sevilla / CSIC / CIBERNED, Spain) |
7:40 pm - 8:25 pm | Thomas Sudhof (Stanford University, USA) "Molecular Mechanisms of Synapse Formation and Restructuring" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Pascal Kaeser (Harvard Medical School, USA) "Assembly and Function of the Presynaptic Active Zone" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Juergen Knoblich (Institute of Molecular Biotechnology, Austria) "Modeling Human Brain Development and Disease in 3D Organoid Culture" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Synapse Formation and Synaptic Plasticity (continued) / Dendritic Development |
| Discussion Leader: Mingjie Zhang (Hong Kong University of Science and Technology, Hong Kong SAR China) |
9:00 am - 9:25 am | Jun Ding (Stanford University School of Medicine, USA) "Mixed Signals - Modulation of Synaptic Plasticity by Midbrain Dopamine Neurons" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Xiang Yu (Institute of Neuroscience, Chinese Academy of Sciences, China) "An Inducing Role for Pre-Synaptic Cadherin/Catenin Complex in Synaptogenesis and Spinogenesis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Lily Jan (University of California, San Francisco, USA) "Unexpected Channel Functions in the Nervous System" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:25 am | Yuh-Nung Jan (University of California, San Francisco, USA) "Dendrite Morphogenesis: From Form to
Function" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Tomomi Shimogori (RIKEN Brain Science Institute, Japan) "Rho Activity of BTBD3-PlexinA4 Complex Induced by Neuronal Activity for Selective Dendrite Removal" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Michael Lin (Stanford University, USA) "Two-Photon Imaging of Brain Activity with Improved ASAP-Family Voltage Indicators" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Yingxi Lin (Massachusetts Institute of Technology, USA) "A Robust Activity Marking (RAM) System for Exploring Active Neuronal Ensembles" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Yi Sun (University of California, Los Angeles, USA) and Yi Zuo (University of California, Santa Cruz, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Neural Stem Cells and Neural Lineage Development |
| Discussion Leader: John Ngai (University of California, Berkeley, USA) |
7:30 pm - 7:55 pm | Simon Hippenmeyer (Institute of Science and Technology Austria, Austria) "Programmed Deterministic Genesis of Neurons and Glia in the Neocortex" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Yukiko Gotoh (University of Tokyo, Japan) "Embryonic vs Adult Neural Stem Cells" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Hongjun Song (Johns Hopkins University, USA) "Single Cell Analysis of Neurogenesis in the Mammalian Brain" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Zhiheng Xu (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China) "Zika Virus Infection Leads to Microcephaly" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Circuits-Based Behavioral Study |
| Discussion Leader: Yuh-Nung Jan (University of California, San Francisco, USA) |
9:00 am - 9:25 am | Qiufu Ma (Harvard Medical School, USA) "Spinal Circuits Transmitting and Gating Mechanical Pain" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Xiaoke Chen (Stanford University, USA) "Brain Circuits Mediating Negative Emotions" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Yi Zuo (University of California, Santa Cruz, USA) "Stress Induces Synaptic and Circuit Reorganization in the Mouse Cerebral Cortex" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Nirao Shah (University of California, San Francisco, USA) "Sensory and Hormonal Control of Social Interactions" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Peng Cao (Institute of Biophysics, Chinese Academy of Sciences, China) "A Brain Circuit to Trigger Fear Responses: Its Identification, Characterization and Preliminary Translational Research" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Wei Wei (The University of Chicago, USA) "Distinct Neural Mechanisms Underlying the On and Off Pathways of Direction Selectivity in the Retina" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Michael Hart (Howard Hughes Medical Institute / Columbia University, USA) "Experience-Dependent GABAergic Structural Plasticity in Male C. Elegans" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
2:00 pm - 4:00 pm | Poster Session |
4:00 pm - 6:00 pm | Epigenetics and Behavioral Plasticity |
| Discussion Leader: Lin Mei (Augusta University, USA) |
4:00 pm - 4:25 pm | Azad Bonni (Washington University School of Medicine in St. Louis, USA) "Epigenetic Regulation of Neuronal Connectivity in the Brain" |
4:25 pm - 4:30 pm | Discussion |
4:30 pm - 4:55 pm | Peng Jin (Emory University, USA) "Active DNA Modifications in Neurodevelopment and Diseases" |
4:55 pm - 5:00 pm | Discussion |
5:00 pm - 5:15 pm | Hao Wu (University of Pennsylvania, USA) "Neuronal DNA Methylome: How Dynamic Is It?" |
5:15 pm - 5:20 pm | Discussion |
5:20 pm - 5:35 pm | Jiang Wu (University of Texas Southwestern Medical Center, USA) "Specific Functions of an Autism-Associated Chromatin Remodeling Complex in Neuron Development" |
5:35 pm - 5:40 pm | Discussion |
5:40 pm - 5:55 pm | Xiaohong Xu (Institute of Neuroscience, Chinese Academy of Sciences, China) "Reciprocal Antagonism Between Hunger and Maternal Care" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Disease Modeling from Yeast to Non-Human Primate |
| Discussion Leader: Louis Reichardt (Simons Foundation, USA) |
9:00 am - 9:25 am | Aaron Gitler (Stanford University, USA) "Expanding Mechanisms and Therapeutic Targets for Neurodegenerative Diseases" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Zilong Qiu (Institute of Neuroscience, Chinese Academy of Sciences, China) "The Non-Human Primate Model for Brain Disorders — What Can We Learn from the Monkey?" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Weizhi Ji (The Yunnan Key Laboratory of Primate Biomedical Research, China) "Modeling Rett Syndrome Using Non-Human Primate via Gene-Editing" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Guo-Li Ming (Johns Hopkins University, USA) "Using Human iPSCs for Modeling Neural Developmental Disorders" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Susan Bookheimer (University of California, Los Angeles, USA) "Translational Approaches to Understanding Developmental Disabilities: Linking Genes, Brain and Behavior in Autism Spectrum Disorders" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Hyunsoo Je (Duke-NUS Graduate Medical School, Singapore) "Synaptic Dysfunction in Autism" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Application of Stem Cells in Disease Modeling and Neural Repair |
| Discussion Leader: Yi Sun (University of California, Los Angeles, USA) |
7:30 pm - 7:55 pm | Gong Chen (Pennsylvania State University, USA) "In Vivo Reprogramming: Reversing Glial Scar for Brain Repair" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Xiaoguang Li (Beihang University, China) "NT-3-Chitosan Elicit Robust Endogenous Neural Stem Cell Activation and Neural Repair After a Severe Case of Spinal Cord Injury" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Kinichi Nakashima (Kyushu University, Japan) "Neural Stem Cell Regulation and Its Therapeutic Application to Spinal Cord Injury" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Keqiang Ye (Emory University, USA) "Delta-Secretase in Alzheimer's Disease and Its Drug Discovery" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Advancements in Understanding Neurodegeneration and Repair |
| Discussion Leader: Wen-Cheng Xiong (Georgia Regents University, USA) |
9:00 am - 9:25 am | Nancy Ip (The Hong Kong University of Science and Technology, Hong Kong SAR China) "Modulation of Innate Immunity in Alzheimer's Disease" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Yimin Zou (University of California, San Diego, USA) "Recovery of Cortical Motor Control After Spinal Cord Injury" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Bai Lu (Tsinghua University School of Medicine, China) "Synaptic Repair Strategy for Neurodegenerative Diseases" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:15 am | Jianzhi Wang (Tongji Medical College, Huazhong University of Science and Technology, China) "Opposite Monosynaptic Scaling of BLP-vCA1 Inputs Governs Hopefulness- and Helplessness-Modulated Spatial Learning and Memory" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Weihong Ge (University of California, Los Angeles, USA) "Transciptome Analyses with WGCNA Reveal Three Key Elements to the Success of Neural Repair in CNS" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Kai Liu (Hong Kong University of Science and Technology, Hong Kong SAR China) "Enhancing Neuronal Activity by Melanopsin/GPCR Signaling Promotes Axon Regeneration in the Adult CNS" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Louis Reichardt (Simons Foundation, USA) "Autism: Scientific Efforts to Overcome Barriers that Limit Understanding, Diagnosis and Treatment" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Connectome, Brain Imaging, and Single Cell Transcriptome Analyses |
| Discussion Leader: Michael Lin (Stanford University, USA) |
4:00 pm - 4:25 pm | Hongwei Dong (University of Southern California, USA) "Assembling Global Neural Networks of the Mouse Brain" |
4:25 pm - 4:30 pm | Discussion |
4:30 pm - 4:55 pm | Jin Hyung Lee (Stanford University, USA) "Investigation of Global Brain Circuit Mechanisms with Cell Type Specificity" |
4:55 pm - 5:00 pm | Discussion |
5:00 pm - 5:25 pm | Zhiping Pang (Robert Wood Johnson Medical School, Rutgers University, USA) "Using Human Neurons to Study Addiction Associated Gene Variants" |
5:25 pm - 5:30 pm | Discussion |
5:30 pm - 5:45 pm | Russell Fletcher (University of California, Berkeley, USA) "Cell Fate Decisions and Lineage Trajectories in the Olfactory Stem Cell Niche" |
5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:00 pm | Closing Remarks |
6:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |