Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Neurological Disease
Discussion Leader: Julia TCW (Boston University School of Medicine, United States)
7:40 pm - 8:20 pm
Carla Shatz (Stanford University, United States)
"Synapses Lost and Found: Developmental Critical Periods and Alzheimer’s Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Li-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, United States)
"Uncovering the Role of Alzheimer’s Disease Risk Genes Using Stem Cells and Human Brains"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Tim Mosca (Thomas Jefferson University, United States)
"A Role for Alzheimer's Disease Risk Genes in Synaptic Maturation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Xin Jin (Scripps Research, United States)
"In Vivo Perturb-Seq: Scaled Investigation of Gene Function in the Developing Brain"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Development of the Nervous System
Discussion Leader: Matthew Dalva (Thomas Jefferson University, United States)
9:00 am - 9:20 am
Gordon Fishell (Harvard Medical School, United States)
"The Developmental Relationship Between Interneurons and Pyramidal Cells Predicts their Mature Connectivity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Shen-Ju Chou (Academia Sinica, Taiwan)
"Regional Patterning of the Cerebral Cortex"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Carina Hanashima (Waseda University, Japan)
"Neuronal Subtype Transitions and Integration in the Cerebral Cortex"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Daichi Kawaguchi (The University of Tokyo, Japan)
"Developmental Cortical Overgrowth Associated with Autism Spectrum Disorder"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Ai Nakashima (University of Tokyo, Japan)
"Cell Type-Specific Patterned Neural Activity Instructs Neural Map Formation in the Mouse Olfactory System"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Peri Kurshan (Albert Einstein College of Medicine, United States)
"Intracellular Interactions with Cytosolic Active Zone Scaffolds Recruit Neurexin and Drive Presynaptic Stabilization in C. elegans"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Melissa Rolls (Pennsylvania State University, United States)
"Neuronal Microtubule Organization in Healthy and Injured Neurons"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Hongyan Wang (Duke-NUS Medical School, Singapore)
"Waking up “Sleeping” Neural Stem Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Xuecai Ge (University of California, Merced, United States)
"Cilium Proteomics Reveals New Regulators of Hedgehog Signaling in Neurodevelopment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Shan Meltzer (Harvard University, United States) and Jun Ding (Stanford University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synapses and Synaptic Function
Discussion Leader: Dion Dickman (University of Southern California, United States)
7:30 pm - 7:50 pm
Peter Scheiffele (Biozentrum, University of Basel, Switzerland)
"RNA Splice Codes for the Development of Neuronal Connectivity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Lu Chen (Stanford University, United States)
"Retinoic Acid Receptor Signaling in Neuropathic Pain"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Camin Dean (DZNE/Charite, Germany)
"Synaptic Mechanisms of Remembering and Forgetting"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Johannes Hell (University of California, Davis, United States)
"Regulation of Postsynaptic AMPAR Trafficking"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Justin Trotter (Stanford University, United States)
"A Combinatorial Code of Neurexin-3 Alternative Splicing Controls Inhibitory Synapses Via a Trans-Synaptic Dystroglycan Signaling Loop"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neural Circuits and Behavior
Discussion Leader: Subhojit Roy (University of California, San Diego, United States)
9:00 am - 9:20 am
Yang Dan (University of California, Berkeley, United States)
"The How and Why of Sleep"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Nirao Shah (Stanford University, United States)
"Functional Cellular Framework for Sexually Dimorphic Social Behaviors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Anna Beyeler (French Institute of Health (INSERM), France)
"Role of Insula Projection Neurons in Valence and Anxiety-Related Behaviors"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Steven Flavell (Massachusetts Institute of Technology, United States)
"Serotonergic Circuits that Control Persistent Behavioral States"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Juan Song (University of North Carolina at Chapel Hill, United States)
"Hypothalamic Modulation of Adult Hippocampal Neurogenesis Contributes to Memory and Emotion Processing"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Yi Zuo (University of California, Santa Cruz, United States)
"Stress and the Brain: Impact, Prevention, and Rescue"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Simon Chen (University of Ottawa, Canada)
"Functionally Distinct NPAS4-expressing Somatostatin Interneuron Ensembles Critical for Motor Learning"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Andy Steele (California State Polytechnic University Pomona, United States)
"Genetic Identification of a Population of Dopamine Neurons That is Necessary for Circadian Food Anticipatory Activity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Brain Imaging and Connectomics
Discussion Leader: Yimin Zou (University of California, San Diego, United States)
7:30 pm - 7:50 pm
Tianyi Mao (Oregon Health and Science University, United States)
"Dissecting Brain Circuits Using Mesoscopic Connectomics and Novel Imaging Modalities"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ryohei Yasuda (Max Planck Florida Institute for Neuroscience, United States)
"Linking Time Scales of Intracellular Signaling and Synaptic, Circuit, and Behavioral Plasticity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Andrew Shuster (Stanford University, United States)
"In Situ Cell-Surface Proteomic Profiling in Mice Identifies a New Regulator of Dendrite Morphogenesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Wei Xu (UT Southwestern, United States)
"Anterograde Transneuronal Targeting of Neurons and Astrocytes for Genetic Control"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Subhojit Roy (University of California, San Diego, United States)
"Synaptic Friends of Alpha Synuclein"
9:10 pm - 9:15 pm
Discussion
9:30 pm - 9:40 pm
Julia TCW (Boston University School of Medicine, United States)
"Cholesterol and Matrisome Pathways Dysregulated in Astrocytes and Microglia"
9:40 pm - 9:45 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics and Epigenetics of the Nervous System
Discussion Leader: Anne West (Duke University , United States)
9:00 am - 9:20 am
Dan Geschwind (University of California, Los Angeles, United States)
"Gene Networks for Drug Discovery in Neurodegenerative Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Martin Kampmann (University of California, San Francisco, United States)
"Elucidating Disease States of Glia Through CRISPR-based Functional Genomics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Giordano Lippi (The Scripps Research Institute, United States)
"Beyond Transcription - Redesigning the Toolbox to Study microRNAs in the Brain"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Chun Han (Cornell University, United States)
"Optogenetic Manipulation of Endogenous Proteins in Drosophila by Light-inducible Trapping"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jie Shen (Harvard Medical School, United States)
"Mechanisms of Neurodegeneration in Familial Alzheimer's Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Lulu Chen (UC Irvine, United States)
"Conditional Deletion of Neurexin 2 Leads to Spontaneous Recurrent Seizures"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Bruce Herring (University of Southern California, United States)
"Schizophrenia-associated SAP97 Mutations Increase Glutamatergic Synapse Strength in the Dentate Gyrus and Impair Contextual Episodic Memory"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Tingting Wang (Georgetown University, United States)
"Glial Epigenetic Signaling in Presynaptic Homeostatic Plasticity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Dong Yan (Duke University, United States)
"Extrasynaptic GABA Signaling Triggered by TMC-1/Tmc Delays Neuronal Aging Through Inhibiting the PKC Pathway"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Sensory Systems
Discussion Leader: John Ngai (National Institutes of Health, United States)
7:30 pm - 7:50 pm
Craig Montell (University of California, Santa Barbara, United States)
"Receptors, Channels and Insect Behavior"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Meg Younger (Boston University, United States)
"Non-Canonical Olfaction in Blood-Drinking Mosquitoes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Chih-Ying Su (University of California, San Diego, United States)
"Beyond Combinatorial code: Valence Opponency in Peripheral Olfactory Processing"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Alexander Chesler (National Institutes of Health, United States)
"Molecules and Cells for Touch and Pain"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Shan Meltzer (Harvard University, United States)
"Different Requirements of γ-Protocadherins in Synapse Formation and Peripheral Branching of Touch Sensory Neurons"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Diana Tavares Ferreira (University of Texas at Dallas, United States)
"Molecular Characteristics of the First Synapses in the Human Pain Pathway"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Neurodegeneration and Regeneration
Discussion Leader: Leonard Petrucelli (Mayo Clinic College of Medicine and Science, United States)
9:00 am - 9:20 am
Jun Ding (Stanford University, United States)
"Synuclein-Dependent Endocannabinoid Release"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Claire Le Pichon (National Institutes of Health, United States)
"The Neuronal Injury Response in Development and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Hyunglok Chung (Baylor College of Medicine, United States)
"Very Long-chain Fatty Acids Induce Glial-derived Sphingosine-1-Phosphate Synthesis, Secretion, and Neuroinflammation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Meng-meng Fu (National Institute of Health, United States)
"TPPP Forms Liquid Condensates and Aggregates in Multiple System Atrophy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
James Shorter (University of Pennsylvania, United States)
"Combating Deleterious Phases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Denethi Wijegunawardana (Yale University, United States)
"Ataxin-2 PolyQ Expansions Aberrantly Sequester TDP-43, Impair Anterograde Transport of Neuronal RNP Condensates Along the Axon and Suppress Translation"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Eric Huang (University of California, San Francisco, United States)
"Glial Toxicity and TDP-43 Proteinopathy: Where Is the Connection?"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Michael Ward (National Institutes of Health, United States)
"Using iPSCs as Discovery Engines for Neurodegenerative Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Neuronal Reprogramming: Mechanisms and Therapeutic Outlook
Discussion Leaders: Hwai-Jong Cheng (Institute of Molecular Biology, Academia Sinica, Taiwan, Taiwan)
7:30 pm - 8:10 pm
Don Cleveland (Ludwig Institute for Cancer Research, United States)
"Identity Theft: Generating New Neurons in the Aging Nervous System"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Xiang-Dong Fu (UCSD, United States)
"The Cellular Origin of PTB Depletion-induced Neurons in the Brain"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Chun-Li Zhang (UT Southwestern Medical Center, United States)
"In Vivo Multilineage Reprogramming of Adult Astrocytes"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure